Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial

Jian-ping Shi; Hong Zhang; Zhi-dong Zhang; Ge-hua Zhang; Ai-li Gao; Shou-bao Xiang

doi:10.1007/s11655-010-0782-3

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Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial

Updated：2021-08-27

- Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial
- Chinese Journal of Integrative Medicine Vol. 17, Issue 7, Pages: 499-504(2011)
- Affiliations：
  
  1. Department of Dermatology, the First Affiliated Hospital, Jinan University,Guangzhou,China
  2. Department of Dermatology, Shajing People’s Hospital,Guangdong Province,Shenzhen,China
  3. The Third Affiliated Hospital, Sun Yat-sen University,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30972660), Foundation of Science and Technology Planning Project of Guangdong Province, China (No. 2009B030801015 and No. 2008B030301350)
- DOI：10.1007/s11655-010-0782-3
  CLC：
- Published：2011，
  
  Published Online：3 July 2011，
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Shi, Jp., Zhang, H., Zhang, Zd. et al. Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial., Chin. J. Integr. Med. 17, 499–504 (2011). https://doi.org/10.1007/s11655-010-0782-3

Jian-ping Shi, Hong Zhang, Zhi-dong Zhang, et al. Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial. [J]. Chinese Journal of Integrative Medicine 17(7):499-504(2011)
Shi, Jp., Zhang, H., Zhang, Zd. et al. Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial., Chin. J. Integr. Med. 17, 499–504 (2011). https://doi.org/10.1007/s11655-010-0782-3 DOI：

Jian-ping Shi, Hong Zhang, Zhi-dong Zhang, et al. Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: A clinical trial. [J]. Chinese Journal of Integrative Medicine 17(7):499-504(2011) DOI： 10.1007/s11655-010-0782-3.

摘要

To evaluate the synergistic effects of tetrandrine (TET) on the antifungal activity of topical ketoconazole (KCZ) in the treatment of dermatophytoses. The minimum inhibitory concentrations (MICs) for KCZ and combined KCZ and TET were compared in vitro. A randomized

double-blind trial was conducted among 97 patients with dermatophytoses who were assigned to 3 groups and received: treatment with combination of 2% KZC and 2% TET cream (KCZ + TET group)

or only 2% KZC cream (KCZ group)

or 2% TET cream (TET group). Patients with tinea corporis and/or tinea cruris were treated for 2 weeks

separately. The patients with tinea pedis and/or tinea manuum were treated for 4 weeks. Compared with KZC alone

combined use of KZC and TET showed lower MICs against clinical isolates of dermatophytes (P<0.05 for all). In the patients with tinea corporis and/or tinea cruris

the rates of overall cure (clinical cure plus mycologic clearance) were 81.25% vs. 33.33% for combined treatment and KZC monotherapy

respectively

after 4 weeks. All clinical indices were significantly different between the combination therapy and only KCZ therapy groups (P<0.05). Among the patients with tinea pedis and/or tinea manuum after 4 weeks treatment

the overall cure rates in the KCZ + TET group and KCZ group were 75.00% vs. 40.00%

respectively. In the KCZ + TET group

all the clinical indices were significantly better than those in the KCZ group and TET group (P<0.05). The rates of overall efficacy in the TET group were all zero. No local skin redness or itching was observed during TET treatment. No clinically significant changes were found in post-treatment routine blood

urine

or stool tests

ECG

or tests for liver and kidney function; no serious adverse events occurred. TET synergistically enhanced the clinical efficacy of topical KZC cream in the treatment of dermatophytoses.

Abstract

double-blind trial was conducted among 97 patients with dermatophytoses who were assigned to 3 groups and received: treatment with combination of 2% KZC and 2% TET cream (KCZ + TET group)

or only 2% KZC cream (KCZ group)

or 2% TET cream (TET group). Patients with tinea corporis and/or tinea cruris were treated for 2 weeks

separately. The patients with tinea pedis and/or tinea manuum were treated for 4 weeks. Compared with KZC alone

combined use of KZC and TET showed lower MICs against clinical isolates of dermatophytes (P<0.05 for all). In the patients with tinea corporis and/or tinea cruris

the rates of overall cure (clinical cure plus mycologic clearance) were 81.25% vs. 33.33% for combined treatment and KZC monotherapy

respectively

the overall cure rates in the KCZ + TET group and KCZ group were 75.00% vs. 40.00%

respectively. In the KCZ + TET group

urine

or stool tests

ECG

or tests for liver and kidney function; no serious adverse events occurred. TET synergistically enhanced the clinical efficacy of topical KZC cream in the treatment of dermatophytoses.

关键词

Tetrandrineketoconazolesynergismdermatophytosis

Keywords

Tetrandrineketoconazolesynergismdermatophytosis

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