Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis

Xiao-lin Shi; Kang Liu; Lian-guo Wu

doi:10.1007/s11655-010-0792-1

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Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis

Updated：2021-08-27

- Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis
- Chinese Journal of Integrative Medicine Vol. 17, Issue 7, Pages: 556-560(2011)
- Affiliations：
  
  Department of Orthopaedics, Second Hospital Affiliated to Zhejiang University of Chinese Medicine,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the China Postdoctoral Science Foundation (No. 20080430537) and the Key Technologies R & D Program of Zhejiang Province (No. 2006C23011)
- DOI：10.1007/s11655-010-0792-1
  CLC：
- Published：2011，
  
  Published Online：3 July 2011，
Scan for full text
Shi, Xl., Liu, K. & Wu, Lg. Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis., Chin. J. Integr. Med. 17, 556–560 (2011). https://doi.org/10.1007/s11655-010-0792-1

Xiao-lin Shi, Kang Liu, Lian-guo Wu. Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis. [J]. Chinese Journal of Integrative Medicine 17(7):556-560(2011)
Shi, Xl., Liu, K. & Wu, Lg. Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis., Chin. J. Integr. Med. 17, 556–560 (2011). https://doi.org/10.1007/s11655-010-0792-1 DOI：

Xiao-lin Shi, Kang Liu, Lian-guo Wu. Interventional value of total flavonoids from Rhizoma Drynariae on Cathepsin K, a potential target of osteoporosis. [J]. Chinese Journal of Integrative Medicine 17(7):556-560(2011) DOI： 10.1007/s11655-010-0792-1.

摘要

Osteoporosis

the sixth most common disease in the world

is bringing increasingly serious harm to people’s health. Cathepsin K

which plays an important role in bone resorption

is a potential target in the treatment of osteoporosis. Total flavonoids

the active ingredients in Rhizoma Drynariae

have shown obvious

therapeutic effect on osteoporosis. In previous studies

it was presumed that the mechanism for the therapeutic effect was through inhibiting the expression of Cathepsin K. However

there are still no detailed reports on some key issues such as the specific inhibitory results of total flavonoids on Cathepsin K and the pathway of inhibition and so on. Based on previous studies on total flavonoids from Rhizoma Drynariae

the pathway for the effect of

total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper

so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.

Abstract

Osteoporosis

the sixth most common disease in the world

is bringing increasingly serious harm to people’s health. Cathepsin K

which plays an important role in bone resorption

is a potential target in the treatment of osteoporosis. Total flavonoids

the active ingredients in Rhizoma Drynariae

have shown obvious

therapeutic effect on osteoporosis. In previous studies

it was presumed that the mechanism for the therapeutic effect was through inhibiting the expression of Cathepsin K. However

the pathway for the effect of

total flavonoids inhibiting Cathepsin K and their interventional value on Cathepsin K were analyzed in this paper

so as to explore the interventional feasibility and value of total flavonoids in Rhizoma Drynariae on Cathepsin K.

关键词

Cathepsin KRhizoma Drynariae DrynariaeFlavonoidOsteoporosis

Keywords

Cathepsin KRhizoma Drynariae DrynariaeFlavonoidOsteoporosis

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