The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial

Yong-qi Dou; Ming-hui Yang; Zheng-mao Wei; Chun Xiao; Xu-hui Yang

doi:10.1007/s11655-010-9998-x

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The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial

Updated：2021-08-27

- The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial
- Chinese Journal of Integrative Medicine Vol. 16, Issue 5, Pages: 411-416(2010)
- Affiliations：
  
  Chinese Medicine Institute of PLA General Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30371826)
- DOI：10.1007/s11655-010-9998-x
  CLC：
- Published：2010，
  
  Published Online：10 June 2010，
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Dou, Yq., Yang, Mh., Wei, Zm. et al. The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial., Chin. J. Integr. Med. 16, 411–416 (2010). https://doi.org/10.1007/s11655-010-9998-x

Yong-qi Dou, Ming-hui Yang, Zheng-mao Wei, et al. The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial. [J]. Chinese Journal of Integrative Medicine 16(5):411-416(2010)
Dou, Yq., Yang, Mh., Wei, Zm. et al. The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial., Chin. J. Integr. Med. 16, 411–416 (2010). https://doi.org/10.1007/s11655-010-9998-x DOI：

Yong-qi Dou, Ming-hui Yang, Zheng-mao Wei, et al. The study of early application with Dixiong Decoction (地芎汤) for non-small cell lung cancer to decrease the incidence and severity of radiation pneumonitis: A prospective, randomized clinical trial. [J]. Chinese Journal of Integrative Medicine 16(5):411-416(2010) DOI： 10.1007/s11655-010-9998-x.

摘要

To evaluate the efficacy of compound Dixiong Decoction (地芎汤

a Chinese herbal decoction) on early prevention of radiation pneumonitis. Forty-six patients with non-small cell lung cancer who were planning to receive radiotherapy were randomly assigned to the treatment group treated with the compound Dixiong Decoction and the control group treated with a commonly used herbal decoction which has the effects of supplementing qi and nourishing yin

clearing heat and detoxifying at the time of radiotherapy. Primary measure was the incidence of radiation pneumonitis after radiotherapy. Secondary outcomes included Watters clinical radiographic physiologic (CRP) dyspnea score

the Radiation Therapy Oncology Group (RTOG) grading score

Karnofsky Performance Status (KPS) score

and the application of corticosteroids. The incidence of radiation pneumonitis in the treatment group was 10.0%

while that in the control group was 26.3% (P=0.0032). The Watters CRP dyspnea score and RTOG grading score in the treatment group were significantly =lower than those in the control group (P<0.05). The KPS score in the treatment group was significantly higher than that in the control group (P<0.01). The dosage of corticosteroids was smaller with a shorter duration of therapy in the treatment group than that in the control group. The early application of the Chinese herbal decoction compound Dixiong Decoction can decrease the incidence of radiation pneumonitis

reduce the injury of the lung

and improve the life quality of the patients.

Abstract

To evaluate the efficacy of compound Dixiong Decoction (地芎汤

the Radiation Therapy Oncology Group (RTOG) grading score

Karnofsky Performance Status (KPS) score

and the application of corticosteroids. The incidence of radiation pneumonitis in the treatment group was 10.0%

reduce the injury of the lung

and improve the life quality of the patients.

关键词

radiation pneumonitiscomplementary and alternative medicineChinese Herbal Medicineclinical trial

Keywords

radiation pneumonitiscomplementary and alternative medicineChinese Herbal Medicineclinical trial

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