Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial

Fu-yong Chu; Jie Wang; Kui-wu Yao; Zhi-zhong Li

doi:10.1007/s11655-010-9999-9

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Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial

Updated：2021-08-27

- Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial
- Chinese Journal of Integrative Medicine Vol. 16, Issue 5, Pages: 399-405(2010)
- Affiliations：
  
  1. Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Rescue Center of Emergency, Anzhen Hospital, China Capital University of Medical Science,Beijing,China,100029
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 90709048) Clinical Trials.;Gov Identifier: NCT00817024
- DOI：10.1007/s11655-010-9999-9
  CLC：
- Published：2010，
  
  Published Online：10 June 2010，
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Chu, Fy., Wang, J., Yao, Kw. et al. Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial., Chin. J. Integr. Med. 16, 399–405 (2010). https://doi.org/10.1007/s11655-010-9999-9

Fu-yong Chu, Jie Wang, Kui-wu Yao, et al. Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 16(5):399-405(2010)
Chu, Fy., Wang, J., Yao, Kw. et al. Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial., Chin. J. Integr. Med. 16, 399–405 (2010). https://doi.org/10.1007/s11655-010-9999-9 DOI：

Fu-yong Chu, Jie Wang, Kui-wu Yao, et al. Effect of Xuefu Zhuyu Capsule (血府逐瘀胶囊) on the symptoms and signs and health-related quality of life in the unstable angina patients with blood-stasis syndrome after percutaneous coronary intervention: A Randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 16(5):399-405(2010) DOI： 10.1007/s11655-010-9999-9.

摘要

Compared with Shengmai Capsule (生脉胶囊

SM)

the study was conducted to evaluate the efficacy and safety of Xuefu Zhuyu Capsule (血府逐瘀胶囊

XFZY) on the symptoms and signs and health-related quality of life (HR-QOL) in the unstable angina (UA) patients with blood-stasis syndrome (BSS) after percutaneous coronary intervention (PCI). A randomized

double-blinded

double-dummy

and placebo-controlled trial was applied. Ninety patients

diagnosed as UA and BSS after successful PCI

were enrolled and equally randomized into three groups

XFZY group

SM group

and placebo group

and administered with the corresponding medications respectively for four weeks. The clinical symptoms and signs (CSS)

electrocardiography (ECG)

and BSS scores were recorded and compared among groups during and after the treatment. Short-form 36 (SF-36) and Seattle Angina Questionnaire (SAQ) were applied to assess the HR-QOL in each group before and after the treatment. Safety indexes (blood routine and liver and kidney function tests) were also examined at the beginning and after the treatment. Eighty-six patients completed the whole study. After the treatment

the total effective rates of the XFZY group in ameliorating CSS and ECG were 76.7% and 60.0%

respectively

which were obviously higher than those in SM (CSS: 53.3%; ECG: 36.7%) and the placebo (CSS: 43.3%; ECG: 30.0%) groups. After one week’s treatment

BSS scores slightly decreased in each group

but no signifificant differences were found among three groups (P>0.05). After four weeks’ treatment

BSS scores in the XFZY group decreased to a lower level compared with SM (P <0.05) and the placebo (P <0.01) groups. After the treatment

the effificacy of XFZY group in improving body pain (BP)

general health (GH)

vitality (VT)

society functioning (SF)

role emotional (RE)

angina stability (AS)

angina frequency (AF)

and treatment satisfaction (TS) were better than those in the placebo group (P <0.05

P <0.01). Meanwhile

the dimensions of BP

and TS were better improved than those in the SM group P <0.05). No obvious adverse reaction was found during and after the treatment except one case in the XFZY group reporting of stomach discomfort. Compared with SM Capsule treatment

a short-term treatment with XFZY Capsule exhibits better effificacy on CSS and BSS scores

and HR-QOL in UA patients with BSS after PCI. However

its long-term effificacy and safety still needs further investigation.

Abstract

Compared with Shengmai Capsule (生脉胶囊

SM)

the study was conducted to evaluate the efficacy and safety of Xuefu Zhuyu Capsule (血府逐瘀胶囊

double-blinded

double-dummy

and placebo-controlled trial was applied. Ninety patients

diagnosed as UA and BSS after successful PCI

were enrolled and equally randomized into three groups

XFZY group

SM group

and placebo group

and administered with the corresponding medications respectively for four weeks. The clinical symptoms and signs (CSS)

electrocardiography (ECG)

the total effective rates of the XFZY group in ameliorating CSS and ECG were 76.7% and 60.0%

respectively

which were obviously higher than those in SM (CSS: 53.3%; ECG: 36.7%) and the placebo (CSS: 43.3%; ECG: 30.0%) groups. After one week’s treatment

BSS scores slightly decreased in each group

but no signifificant differences were found among three groups (P>0.05). After four weeks’ treatment

BSS scores in the XFZY group decreased to a lower level compared with SM (P <0.05) and the placebo (P <0.01) groups. After the treatment

the effificacy of XFZY group in improving body pain (BP)

general health (GH)

vitality (VT)

society functioning (SF)

role emotional (RE)

angina stability (AS)

angina frequency (AF)

and treatment satisfaction (TS) were better than those in the placebo group (P <0.05

P <0.01). Meanwhile

the dimensions of BP

a short-term treatment with XFZY Capsule exhibits better effificacy on CSS and BSS scores

and HR-QOL in UA patients with BSS after PCI. However

its long-term effificacy and safety still needs further investigation.

关键词

Xuefu Zhuyu CapsuleUnstable AnginaPercutaneous Coronary Interventiondouble-blinddouble-dummy

Keywords

Xuefu Zhuyu CapsuleUnstable AnginaPercutaneous Coronary Interventiondouble-blinddouble-dummy

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