Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients

Mei-hua Wan; Juan Li; Han-lin Gong; Ping Xue; Lin Zhu; Guang-yuan Chen; Qing Xia; Tang Wen-fu

doi:10.1007/s11655-011-0630-5

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Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients

Updated：2021-08-27

- Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients
- Chinese Journal of Integrative Medicine Vol. 17, Issue 2, Pages: 141-145(2011)
- Affiliations：
  
  Department of Integrative Medicine, West China Hospital, Sichuan University,Chengdu,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30400576, 30801457)
- DOI：10.1007/s11655-011-0630-5
  CLC：
- Published：2011，
  
  Published Online：9 March 2011，
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Wan, Mh., Li, J., Gong, Hl. et al. Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients., Chin. J. Integr. Med. 17, 141–145 (2011). https://doi.org/10.1007/s11655-011-0630-5

Mei-hua Wan, Juan Li, Han-lin Gong, et al. Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients. [J]. Chinese Journal of Integrative Medicine 17(2):141-145(2011)
Wan, Mh., Li, J., Gong, Hl. et al. Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients., Chin. J. Integr. Med. 17, 141–145 (2011). https://doi.org/10.1007/s11655-011-0630-5 DOI：

Mei-hua Wan, Juan Li, Han-lin Gong, et al. Clinical observation on the effect of dexamethasone and chinese herbal decoction for purgation in severe acute pancreatitis patients. [J]. Chinese Journal of Integrative Medicine 17(2):141-145(2011) DOI： 10.1007/s11655-011-0630-5.

摘要

To investigate the effect of dexamethasone (Dx) combined with modified Dachengqi Decoction (大承气汤

DCQD)

a Chinese herbal decoction for purgation

on patients with severe acute on patients with severe acute

a Chinese herbal decoction for purgation

on patients with severe acute pancreatitis (SAP) accompanied with systematic inflammatory response syndrome (SIRS). A total of 81 patients diagnosed as SAP were randomly assigned to a control group or treatment group according to a random number table generated from an SPSS software. The patients in the control group (38 cases) received standard treatment and Chinese herbal decoction for purgation; those in the treatment group (43 cases) received additional 1 mg/(kg·d) dexamethasone (Dx) treatment for three days based on the above treatment. The mortality rate

acute respiratory distress syndrome (ARDS)

renal failure

hemorrhage

sepsis

pancreatic pseudocyst

pancreatic abscess

operability

and days of hospitalization were compared between the two groups. Three patients in the control group and eight patients in the treatment group dropped out from the study with a drop-out rate of 7.8% and 18.6%

respectively

and no statistics difference was shown between the two groups (P>0.05). Dx treatment significantly reduced ARDS rate and shortened the length of hospitalization compared to those in the control group (7/35

20.0% versus 15/35

42.9%

P=0.0394; 32.5±13.2 days versus 40.2±17.5 days

P=0.0344). Other parameters including the mortality rate were not significant different between the two groups. Dx combined with DCQD could decrease the risk of developing ARDS in SAP patients with SIRS and shorten their length of hospitalization.

Abstract

To investigate the effect of dexamethasone (Dx) combined with modified Dachengqi Decoction (大承气汤

DCQD)

a Chinese herbal decoction for purgation

on patients with severe acute on patients with severe acute

a Chinese herbal decoction for purgation

acute respiratory distress syndrome (ARDS)

renal failure

hemorrhage

sepsis

pancreatic pseudocyst

pancreatic abscess

operability

respectively

20.0% versus 15/35

42.9%

P=0.0394; 32.5±13.2 days versus 40.2±17.5 days

关键词

severe acute pancreatitissystematic inflammatory response syndromeacute respiratory distress syndromedexamethasoneDachengqi decoction

Keywords

severe acute pancreatitissystematic inflammatory response syndromeacute respiratory distress syndromedexamethasoneDachengqi decoction

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Department of Integrated Chinese and Western Medicine, West China Hospital of Sichuan University

Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University

Department of General Surgery, West China Hospital, Sichuan University

Department of General Surgery, First Affiliated Hospital, Dalian Medical University

School of Medicine, Nanjing University Nanjing

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