Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse

Yan-zhi Chen; Fei Lin; Gui-bao Zhuang; Yan Ren; Ping-ping Li

doi:10.1007/s11655-011-0634-1

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Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse

Updated：2021-08-27

- Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse
- Chinese Journal of Integrative Medicine Vol. 17, Issue 6, Pages: 453-458(2011)
- Affiliations：
  
  1. Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Integration of Traditional Chinese and Western Medicine, Peking University School of Oncology, Beijing Cancer Hospital & Institute,Beijing,China
  2. National Institute for the Control of Pharmaceutical and Biological Products,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Scientific and Technologic Items of Traditional Chinese Medicine Administration of Beijing City (No. 2004 JingZhongZhong IV 15)
- DOI：10.1007/s11655-011-0634-1
  CLC：
- Published：2011，
  
  Published Online：30 March 2011，
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Chen, Yz., Lin, F., Zhuang, Gb. et al. Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse., Chin. J. Integr. Med. 17, 453–458 (2011). https://doi.org/10.1007/s11655-011-0634-1

Yan-zhi Chen, Fei Lin, Gui-bao Zhuang, et al. Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse. [J]. Chinese Journal of Integrative Medicine 17(6):453-458(2011)
Chen, Yz., Lin, F., Zhuang, Gb. et al. Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse., Chin. J. Integr. Med. 17, 453–458 (2011). https://doi.org/10.1007/s11655-011-0634-1 DOI：

Yan-zhi Chen, Fei Lin, Gui-bao Zhuang, et al. Protective effect of Renshen Yangrong Decoction (人参养荣汤) on bone marrow against radiation injury in mouse. [J]. Chinese Journal of Integrative Medicine 17(6):453-458(2011) DOI： 10.1007/s11655-011-0634-1.

摘要

To explore the effect of Renshen Yangrong Decoction (人参养荣汤

RYD) in protecting bone marrow from radiation injury. One hundred and eighty Kuming mice were subjected to the three tests for anti-radiation injury effect evaluation

i.e. the test of peripheral white blood cell (WBC) count

the test of bone marrow nucleated cell count

and the bone marrow micronucleus test

using 60 mice for each test. The mice in each test were divided into 6 groups: the blank control group

the model control group

the positive control group treated by Shiyiwei Shenqi Tablet (十一味参芪片

1.0 g/kg)

and three RYD groups treated with high (42.0 g/kg)

moderate (21.0 g/kg)

and low (10.5 g/kg) doses of crude drugs of RYD

with 10 mice in each group. The treatment was given by gastrogavage perfusion continuously for 7–14 days before mice received 60Co-γ ray radiation and continued until the end of the experiment. The body weights of the mice were monitored

the changes in peripheral WBC and bone marrow nucleated cells were counted

and the variation in bone marrow micronucleated cells was observed on the respective appointed days. A significant decrease in body weight

peripheral WBC count

and bone marrow nucleated cell count

as well as marked changes in bone marrow micronucleated cells were observed in the mice after radiation

indicating that the radiation injury model was successfully established. As compared with the model control group

the decrease in body weight

peripheral WBC count

and bone marrow nucleated cell count

as well as the increase in bone marrow micronucleus cell count in the high dosage RYD treated group were obviously inhibited or lessened (P<0.05 or P<0.01). RYD showed obvious protective effect in mice with bone marrow injury induced by radiation.

Abstract

To explore the effect of Renshen Yangrong Decoction (人参养荣汤

RYD) in protecting bone marrow from radiation injury. One hundred and eighty Kuming mice were subjected to the three tests for anti-radiation injury effect evaluation

i.e. the test of peripheral white blood cell (WBC) count

the test of bone marrow nucleated cell count

and the bone marrow micronucleus test

using 60 mice for each test. The mice in each test were divided into 6 groups: the blank control group

the model control group

the positive control group treated by Shiyiwei Shenqi Tablet (十一味参芪片

1.0 g/kg)

and three RYD groups treated with high (42.0 g/kg)

moderate (21.0 g/kg)

and low (10.5 g/kg) doses of crude drugs of RYD

the changes in peripheral WBC and bone marrow nucleated cells were counted

and the variation in bone marrow micronucleated cells was observed on the respective appointed days. A significant decrease in body weight

peripheral WBC count

and bone marrow nucleated cell count

as well as marked changes in bone marrow micronucleated cells were observed in the mice after radiation

indicating that the radiation injury model was successfully established. As compared with the model control group

the decrease in body weight

peripheral WBC count

and bone marrow nucleated cell count

关键词

Renshen Yangrong Decoctionmouseanti-radiationPeripheral White Blood Cell Countbone marrow nucleated cell countbone marrow micronucleus count

Keywords

Renshen Yangrong Decoctionmouseanti-radiationPeripheral White Blood Cell Countbone marrow nucleated cell countbone marrow micronucleus count

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Department of General Practice, the Second Affiliated Hospital of Zhejiang University Medical College

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Reproductive Center, the Affiliated Hospital of Shandong, University of Traditional Chinese Medicine

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