Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine

Batur Mamtimin; Halmurat Upur; Fu-hua Hao; Aynur Matsidik; Rena Rahim

doi:10.1007/s11655-011-0638-x

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Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine

Updated：2021-08-27

- Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine
- Chinese Journal of Integrative Medicine Vol. 17, Issue 2, Pages: 111-115(2011)
- Affiliations：
  
  1. College of Pharmacy, Zhongnan University,Changsha,China
  2. College of Pharmacy, Xinjiang Medical University,Urumqi,China
  3. State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics, Wuhan Institute of Physics and Mathematics, the Chinese Academy of Sciences,Wuhan,China
  4. Faculty of Traditional Uyghur Medicine, Xinjiang Medical University,Urumqi,China
- Author bio：
- Funds：
  
  Supported by the Program for Changjiang Scholar and Innovative Team (No. IRT0977)
- DOI：10.1007/s11655-011-0638-x
  CLC：
- Published：2011，
  
  Published Online：9 March 2011，
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Mamtimin, B., Upur, H., Hao, Fh. et al. Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine., Chin. J. Integr. Med. 17, 111–115 (2011). https://doi.org/10.1007/s11655-011-0638-x

Batur Mamtimin, Halmurat Upur, Fu-hua Hao, et al. Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine. [J]. Chinese Journal of Integrative Medicine 17(2):111-115(2011)
Mamtimin, B., Upur, H., Hao, Fh. et al. Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine., Chin. J. Integr. Med. 17, 111–115 (2011). https://doi.org/10.1007/s11655-011-0638-x DOI：

Batur Mamtimin, Halmurat Upur, Fu-hua Hao, et al. Plasma metabonomic analysis with 1H nuclear magnetic resonance revealing the relationship of different tumors and the disease homology theory of traditional Uyghur medicine. [J]. Chinese Journal of Integrative Medicine 17(2):111-115(2011) DOI： 10.1007/s11655-011-0638-x.

摘要

To investigate the plasma samples obtained from tumor patients using 1H nuclear magnetic resonance (NMR) spectroscopy

and find the biochemical foundation of abnormal Savda described in traditional Uyghur medicine. A total of 170 tumor patients with abnormal Savda syndrome who were confirmed clinically were enrolled in this study

and 50 healthy volunteers were set up as controls. The plasma 1H NMR spectra were analyzed using the orthogonal projection to latent structure with discriminant analysis (OPLS-DA) method with unit variance scaling. The discriminative significance of the metabolites was determined using the Pearson’s product-moment correlation coefficient. Compared with the healthy controls

the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine

isoleucine

valine

histidine

tyrosine

alanine

glutamine

creatine

inositol

α-glucose

and β-glucose (P<0.05)

but had significantly high levels of formate

malonic acid

acetone

acetate

acetoacetate

pyruvate

β-hydroxy butyrate

carnitine and lipidtemns such as very low density lipoprotein

low density lipoprotein and unsaturated lipids (P<0.05). Tumor patients with abnormal Savda syndrome had similar metabolic changes and characteristics

which indicated a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory.

Abstract

To investigate the plasma samples obtained from tumor patients using 1H nuclear magnetic resonance (NMR) spectroscopy

the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine

isoleucine

valine

histidine

tyrosine

alanine

glutamine

creatine

inositol

α-glucose

and β-glucose (P<0.05)

but had significantly high levels of formate

malonic acid

acetone

acetate

acetoacetate

pyruvate

β-hydroxy butyrate

carnitine and lipidtemns such as very low density lipoprotein

low density lipoprotein and unsaturated lipids (P<0.05). Tumor patients with abnormal Savda syndrome had similar metabolic changes and characteristics

which indicated a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory.

关键词

tumorabnormal Savdatraditional Uyghur medicinemetabonomics

Keywords

tumorabnormal Savdatraditional Uyghur medicinemetabonomics

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