Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice

Ji Pang; Jin-peng Guo; Min Jin; Zhi-qiang Chen; Xin-wei Wang; Jun-wen Li

doi:10.1007/s11655-011-0642-1

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Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice

Updated：2021-08-27

- Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice
- Chinese Journal of Integrative Medicine Vol. 17, Issue 10, Pages: 764-769(2011)
- Affiliations：
  
  1. Institution of Healthy and Toxicology, Beijing Centers for Disease Prevention and Control,Beijing,China
  2. Disease Prevention and Control Institute of the Chinese People’s Liberation Army,Tianjin,China
  3. Department of Environment and Health, Institute of Environmental and Health,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the National High Technology Research and Development Program of China (863 Program, No. 2006AA06Z408)
- DOI：10.1007/s11655-011-0642-1
  CLC：
- Published：2011，
  
  Published Online：26 March 2013，
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Pang, J., Guo, Jp., Jin, M. et al. Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice., Chin. J. Integr. Med. 17, 764–769 (2011). https://doi.org/10.1007/s11655-011-0642-1

Ji Pang, Jin-peng Guo, Min Jin, et al. Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice. [J]. Chinese Journal of Integrative Medicine 17(10):764-769(2011)
Pang, J., Guo, Jp., Jin, M. et al. Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice., Chin. J. Integr. Med. 17, 764–769 (2011). https://doi.org/10.1007/s11655-011-0642-1 DOI：

Ji Pang, Jin-peng Guo, Min Jin, et al. Antiviral effects of aqueous extract from Spatholobus suberectus Dunn. against coxsackievirus B3 in mice. [J]. Chinese Journal of Integrative Medicine 17(10):764-769(2011) DOI： 10.1007/s11655-011-0642-1.

摘要

To investigate the antiviral effects of the aqueous extract of Spatholobus suberectus Dunn. (A.E.)

a Chinese medicinal herb

against coxsackievirus B3 (CVB3). The antiviral effects of A.E. against CVB3 in vitro (primarily cultured myocardial cells) and in vivo (BALB/c mice) were determined. Serum pharmacological method was also adopted by in vitro experiments. The effects of A.E. inhibiting the CVB3 mRNA expression were compared by RT-PCR in mice in vivo. A.E. exhibited obvious antiviral: effects in vivo

and serum samples obtained from the rats with oral administration of A.E. (10 μg/mL

5 μg/mL)

reduced the virus titers in the infected myocardial cells (3.00±0.70

3.55±0.52

P<0.01). Meanwhile

the viral myocarditis induced by CVB3 was inhibited significantly by A.E.

and the 15-day mortality was reduced to 40% and 45% (P<0.01) in mice treated with A.E. at doses of 50 mg/kg and 100 mg/kg

respectively

while the 30-day mortality was decreased to 45% and 50%

respectively (P<0.01). Moreover

the mRNA expression of Coxsackie virus B3 was significantly inhibited by A.E. Aqueous extract of Spatholobus suberectus Dunn. (A.E.) has inhibitory effect on CVB3 both in vitro and in vivo.

Abstract

To investigate the antiviral effects of the aqueous extract of Spatholobus suberectus Dunn. (A.E.)

a Chinese medicinal herb

and serum samples obtained from the rats with oral administration of A.E. (10 μg/mL

5 μg/mL)

reduced the virus titers in the infected myocardial cells (3.00±0.70

3.55±0.52

P<0.01). Meanwhile

the viral myocarditis induced by CVB3 was inhibited significantly by A.E.

and the 15-day mortality was reduced to 40% and 45% (P<0.01) in mice treated with A.E. at doses of 50 mg/kg and 100 mg/kg

respectively

while the 30-day mortality was decreased to 45% and 50%

respectively (P<0.01). Moreover

the mRNA expression of Coxsackie virus B3 was significantly inhibited by A.E. Aqueous extract of Spatholobus suberectus Dunn. (A.E.) has inhibitory effect on CVB3 both in vitro and in vivo.

关键词

aqueous extract of Spatholobus suberectus Dunn.Coxsackievirus B3Viral Myocarditis

Keywords

aqueous extract of Spatholobus suberectus Dunn.Coxsackievirus B3Viral Myocarditis

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