Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)

Pei-xun Liu; Jing Gao; Yu-jie Chen; Wei Long; Xiu Shen; Wei-sheng Tang

doi:10.1007/s11655-011-0644-z

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Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)

Updated：2021-08-27

- Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)
- Chinese Journal of Integrative Medicine Vol. 17, Issue 6, Pages: 459-463(2011)
- Affiliations：
  
  Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin Key Laboratory of Molecular Nuclear Medicine,Tianjin,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0644-z
  CLC：
- Published：2011，
  
  Published Online：10 June 2011，
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Liu, Px., Gao, J., Chen, Yj. et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)., Chin. J. Integr. Med. 17, 459–463 (2011). https://doi.org/10.1007/s11655-011-0644-z

Pei-xun Liu, Jing Gao, Yu-jie Chen, et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方). [J]. Chinese Journal of Integrative Medicine 17(6):459-463(2011)
Liu, Px., Gao, J., Chen, Yj. et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方)., Chin. J. Integr. Med. 17, 459–463 (2011). https://doi.org/10.1007/s11655-011-0644-z DOI：

Pei-xun Liu, Jing Gao, Yu-jie Chen, et al. Anticancer activity of total flavonoids isolated from Xianhe Yanling Recipe (仙鹤延龄方). [J]. Chinese Journal of Integrative Medicine 17(6):459-463(2011) DOI： 10.1007/s11655-011-0644-z.

摘要

To investigate the anticancer activity of the total flavonoids isolated from a herbal formula

Xianhe Yanling Recipe (仙鹤延龄方)

a recipe commonly used in cancer patients in China. The in vitro anticancer activity of the total flavonoids was determined using the 3-(4

5-dimethylthiazole-2-yl)-2

5-diphenyltetrazolium bromide (MTT) assay on three cancer cell lines: MCF-7 (a human breast adenocarcinoma cell line)

HepG-2 (a human hepatocellular carcinoma cell line) and ES-2 (a human ovarian cancer cell line). The in vivo anticancer effect of the total flavonoids was assessed in a mouse tumor model bearing H22-induced hepatocellular carcinoma

and cisplatin was used as a positive control. The total flavonoids exerted a powerful inhibitory effect on the three cell lines

with 50% inhibiting concentrations (IC50) of 24.948

31.569 and 6.923 μg/mL

respectively. In vivo studies showed that the total flavonoids had dose-dependent inhibitory effects on hepatocellular carcinoma in mice. The total flavonoids from Xianhe Yanling Recipe have potential anticancer activity

and further researches and development are warranted.

Abstract

To investigate the anticancer activity of the total flavonoids isolated from a herbal formula

Xianhe Yanling Recipe (仙鹤延龄方)

a recipe commonly used in cancer patients in China. The in vitro anticancer activity of the total flavonoids was determined using the 3-(4

5-dimethylthiazole-2-yl)-2

5-diphenyltetrazolium bromide (MTT) assay on three cancer cell lines: MCF-7 (a human breast adenocarcinoma cell line)

and cisplatin was used as a positive control. The total flavonoids exerted a powerful inhibitory effect on the three cell lines

with 50% inhibiting concentrations (IC50) of 24.948

31.569 and 6.923 μg/mL

and further researches and development are warranted.

关键词

anticancerflavonoidsXianhe Yanling Recipe3-(45-dimethylthiazole-2-yl)-25-diphenyltetrazolium bromide assayin vivo

Keywords

anticancerflavonoidsXianhe Yanling Recipe3-(45-dimethylthiazole-2-yl)-25-diphenyltetrazolium bromide assayin vivo

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Related Institution

Department of Carcliology and Neurology, Hospital of Oriental Medicine, Kyung Hee University

Department of Herbal Pharmacology, College of Korean Medicine, Kyung Hee University

Key Laboratory of Chinese Medicine on Viral Diseases, Ministry of Education, Microbiology and Immunology Department, Beijing University of Chinese Medicine

Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine

Department of Neurology, Qilu Hospital, Shandong University

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