FOLLOWUS
The relevance between symptoms and magnetic resonance imaging analysis of the hippocampus of depressed patients given electro-acupuncture combined with Fluoxetine intervention — A randomized, controlled trial
- Chinese Journal of Integrative Medicine Vol. 17, Issue 3, Pages: 190-199(2011)
- Affiliations：
1. Department of Traditional Chinese Medicine of South Building, Chinese PLA General Hospital,Beijing,China
2. Department of Acupuncture, Beijing University of Chinese Medicine,Beijing,China
3. Department of Rehabilitation, Beijing Friendship Hospital Affiliated to Capital Medical University,Beijing,China
4. Department of Radiology, Beijing Xuanwu Hospital Affi liated to Capital Medical University,Beijing,China
- Author bio：
- Funds：Supported by National Natural Science Foundation of China (No. 30701122) and Beijing Natural Science Foundation (No. 7051003)
DOI：10.1007/s11655-011-0666-6
CLC：Published：2011，
Published Online：27 February 2011，
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Duan, Dm., Tu, Y., Jiao, S. et al. The relevance between symptoms and magnetic resonance imaging analysis of the hippocampus of depressed patients given electro-acupuncture combined with Fluoxetine intervention — A randomized, controlled trial., Chin. J. Integr. Med. 17, 190–199 (2011). https://doi.org/10.1007/s11655-011-0666-6
Dong-mei Duan, Ya Tu, Shuang Jiao, et al. The relevance between symptoms and magnetic resonance imaging analysis of the hippocampus of depressed patients given electro-acupuncture combined with Fluoxetine intervention — A randomized, controlled trial. [J]. Chinese Journal of Integrative Medicine 17(3):190-199(2011)
Duan, Dm., Tu, Y., Jiao, S. et al. The relevance between symptoms and magnetic resonance imaging analysis of the hippocampus of depressed patients given electro-acupuncture combined with Fluoxetine intervention — A randomized, controlled trial., Chin. J. Integr. Med. 17, 190–199 (2011). https://doi.org/10.1007/s11655-011-0666-6 DOI：
Dong-mei Duan, Ya Tu, Shuang Jiao, et al. The relevance between symptoms and magnetic resonance imaging analysis of the hippocampus of depressed patients given electro-acupuncture combined with Fluoxetine intervention — A randomized, controlled trial. [J]. Chinese Journal of Integrative Medicine 17(3):190-199(2011) DOI： 10.1007/s11655-011-0666-6.
摘要
To probe the relevance between depressive symptoms and hippocampal volume and its metabolites detected by magnetic resonance imaging (MRI) in depressed patients who were given electro-acupuncture (EA) combined with Fluoxetine before and after treatment. A randomized
controlled trial was conducted. A total of 75 cases of mild or moderate depression were randomly assigned to two groups: the EA group which received EA combined with Fluoxetine; the Fluoxetine group which received Fluoxetine only as the control. The 17-item Hamilton Scale for Depression (HAMD) was used to assess the depression level. The relevance between the changes of the hippocampal volume and its metabolites
including N-acetyl aspartate (NAA)/creatine (Cr) and choline containing compounds (Cho)/Cr
and the reduction rate of the HAMD score before and after treatment of the two groups were analyzed. At the end of the treatment
the therapeutic response rates were not statistically different between the two groups (73.53% for the Fluoxetine group and 83.33% for the EA group
respectively). Compared to that of the Fluoxetine group
a significant difference was shown in the EA group in the reduction rate of the HAMD scores (P<0.05). There was a negative correlation between the therapeutic effect and the HAMD scores before treatment in both groups of patients. There was no significant difference in the hippocampal volume before and after treatment. The NAA/Cr ratio of both groups increased after treatment
with the EA group increasing more. There was a negative correlation between the rate of change of the NAA/Cr after treatment and the HAMD scores before treatment in the two groups. In the Fluoxetine group
the Cho/Cr ratio showed no significant difference before and after treatment
which had no relevance with the HAMD scores before treatment either. Meanwhile
in the EA group
the Cho/Cr ratio showed a significant difference before and after treatment
which also had a positive relevance with the HAMD scores before treatment. There was a significant improvement in the hippocampal metabolites in depressed patients who treated by EA combined with Fluoxetine. Those differences showed relevance with the HAMD scores before treatment.
Abstract
To probe the relevance between depressive symptoms and hippocampal volume and its metabolites detected by magnetic resonance imaging (MRI) in depressed patients who were given electro-acupuncture (EA) combined with Fluoxetine before and after treatment. A randomized
controlled trial was conducted. A total of 75 cases of mild or moderate depression were randomly assigned to two groups: the EA group which received EA combined with Fluoxetine; the Fluoxetine group which received Fluoxetine only as the control. The 17-item Hamilton Scale for Depression (HAMD) was used to assess the depression level. The relevance between the changes of the hippocampal volume and its metabolites
including N-acetyl aspartate (NAA)/creatine (Cr) and choline containing compounds (Cho)/Cr
and the reduction rate of the HAMD score before and after treatment of the two groups were analyzed. At the end of the treatment
the therapeutic response rates were not statistically different between the two groups (73.53% for the Fluoxetine group and 83.33% for the EA group
respectively). Compared to that of the Fluoxetine group
a significant difference was shown in the EA group in the reduction rate of the HAMD scores (P<0.05). There was a negative correlation between the therapeutic effect and the HAMD scores before treatment in both groups of patients. There was no significant difference in the hippocampal volume before and after treatment. The NAA/Cr ratio of both groups increased after treatment
with the EA group increasing more. There was a negative correlation between the rate of change of the NAA/Cr after treatment and the HAMD scores before treatment in the two groups. In the Fluoxetine group
the Cho/Cr ratio showed no significant difference before and after treatment
which had no relevance with the HAMD scores before treatment either. Meanwhile
in the EA group
the Cho/Cr ratio showed a significant difference before and after treatment
which also had a positive relevance with the HAMD scores before treatment. There was a significant improvement in the hippocampal metabolites in depressed patients who treated by EA combined with Fluoxetine. Those differences showed relevance with the HAMD scores before treatment.
关键词
depressionelectro-acupuncturehippocampusmagnetic resonance imagingFluoxetine
Keywords
depressionelectro-acupuncturehippocampusmagnetic resonance imagingFluoxetine
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