Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

Yin Shi; En-hua Zhou; Huan-gan Wu; Ci-li Zhou; Qian-yao Wang; Li Qi

doi:10.1007/s11655-011-0669-3

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Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2

Updated：2021-08-27

- Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2
- Chinese Journal of Integrative Medicine Vol. 17, Issue 3, Pages: 212-217(2011)
- Affiliations：
  
  1. Shanghai Institute of Acupuncture-Moxibustion and Meridians, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Department of Mechanics and Engineering Science, Fudan University,Shanghai,China
- Author bio：
- Funds：
  
  Supported by National Basic Research Program of China (973 Program, No. 2009CB522900), National Natural Science Foundation of China (No. 30772831), and the Open Fund of Key Laboratory of Acupuncture Combined with Medication (Najing University of Traditional Chinese Medicine), Ministry of Education (Grant No. KJA200809)
- DOI：10.1007/s11655-011-0669-3
  CLC：
- Published：2011，
  
  Published Online：27 February 2011，
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Shi, Y., Zhou, Eh., Wu, Hg. et al. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2., Chin. J. Integr. Med. 17, 212–217 (2011). https://doi.org/10.1007/s11655-011-0669-3

Yin Shi, En-hua Zhou, Huan-gan Wu, et al. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. [J]. Chinese Journal of Integrative Medicine 17(3):212-217(2011)
Shi, Y., Zhou, Eh., Wu, Hg. et al. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2., Chin. J. Integr. Med. 17, 212–217 (2011). https://doi.org/10.1007/s11655-011-0669-3 DOI：

Yin Shi, En-hua Zhou, Huan-gan Wu, et al. Moxibustion treatment restoring the intestinal epithelium barrier in rats with Crohn’s disease by down-regulating tumor necrosis factor alpha, tumor necrosis factor receptor 1, and tumor necrosis factor receptor 2. [J]. Chinese Journal of Integrative Medicine 17(3):212-217(2011) DOI： 10.1007/s11655-011-0669-3.

摘要

To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α)

tumor necrosis factor receptor 1 (TNFR1)

and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism

to repair the intestinal epithelium barrier disruption in Crohn’s disease (CD). The CD rat models were established by trinitrobenzene sulfonic acid (TNBs)

randomly divided into a model control (MC) group

an herb-partition moxibustion (HPM) group

a mild-warm moxibustion (MWM) group

and a salicylazosulfapyridine (SASP) group

and all were compared with a normal control (NC) group. The HPM and MWM groups were treated by moxibustion at Tianshu (ST25) and Qihai (RN6) for 14 days

and the SASP group obtained the SASP solution orally for the same period of time. The intestinal epithelium morphology and TNF-α

TNFR1

and TNFR2 contents were observed by the transmission electron microscopy and enzyme linked immunosorbent assay. The severity of morphological changes in CD intestinal epithelium was obviously improved

and the levels of TNF-α

TNFR1

and TNFR2 in the intestinal mucosa all significantly decreased in the HPM and MWM groups. However

there were no significant differences between the HPM and MWM groups. The moxibustion therapies (HPM and MWM) could reduce intestinal inflammation and restore intestinal epithelium barrier disruption in CD

which might be due to down-regulating TNF-α

TNFR1

and TNFR2 in intestinal mucosa and improving intestinal epithelium morphology.

Abstract

To investigate whether moxibustion regulates tumor necrosis factor alpha (TNF-α)

tumor necrosis factor receptor 1 (TNFR1)

and TNFR2 in the intestinal mucosa and to explore whether moxibustion could be used by means of this mechanism

to repair the intestinal epithelium barrier disruption in Crohn’s disease (CD). The CD rat models were established by trinitrobenzene sulfonic acid (TNBs)

randomly divided into a model control (MC) group

an herb-partition moxibustion (HPM) group

a mild-warm moxibustion (MWM) group

and a salicylazosulfapyridine (SASP) group

and all were compared with a normal control (NC) group. The HPM and MWM groups were treated by moxibustion at Tianshu (ST25) and Qihai (RN6) for 14 days

and the SASP group obtained the SASP solution orally for the same period of time. The intestinal epithelium morphology and TNF-α

TNFR1

and the levels of TNF-α

TNFR1

and TNFR2 in the intestinal mucosa all significantly decreased in the HPM and MWM groups. However

which might be due to down-regulating TNF-α

TNFR1

and TNFR2 in intestinal mucosa and improving intestinal epithelium morphology.

关键词

moxibustionCrohn’s diseasetumor necrosis factor alphatumor necrosis factor receptor 1tumor necrosis factor receptor 2

Keywords

moxibustionCrohn’s diseasetumor necrosis factor alphatumor necrosis factor receptor 1tumor necrosis factor receptor 2

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