Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion

Yuan-zhi Yuan; Fei Yuan; Qin-yue Xu; Jia Yu; Lei Li; Ju-li Zhang

doi:10.1007/s11655-011-0690-6

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Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion

Updated：2021-08-27

- Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion
- Chinese Journal of Integrative Medicine Vol. 17, Issue 4, Pages: 296-301(2011)
- Affiliations：
  
  1. Department of Ophthalmology, Zhongshan Hospital, Fudan University,Shanghai,China
  2. Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital, Fudan University,Shanghai,China
  3. Nursing Department, Zhongshan Hospital, Fudan University,Shanghai,China
- Author bio：
- Funds：
  
  Supported in part by Science and Technology Commission of Shanghai Municipality (Grant No. 074119510).
- DOI：10.1007/s11655-011-0690-6
  CLC：
- Published：2011，
  
  Published Online：21 April 2011，
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Yuan, Yz., Yuan, F., Xu, Qy. et al. Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion., Chin. J. Integr. Med. 17, 296–301 (2011). https://doi.org/10.1007/s11655-011-0690-6

Yuan-zhi Yuan, Fei Yuan, Qin-yue Xu, et al. Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion. [J]. Chinese Journal of Integrative Medicine 17(4):296-301(2011)
Yuan, Yz., Yuan, F., Xu, Qy. et al. Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion., Chin. J. Integr. Med. 17, 296–301 (2011). https://doi.org/10.1007/s11655-011-0690-6 DOI：

Yuan-zhi Yuan, Fei Yuan, Qin-yue Xu, et al. Effect of Fufang Xueshuantong Capsule (复方血栓通胶囊) on a rat model of retinal vein occlusion. [J]. Chinese Journal of Integrative Medicine 17(4):296-301(2011) DOI： 10.1007/s11655-011-0690-6.

摘要

To establish a retinal vein occlusion (RVO) animal model and observe the therapeutic effect of a Chinese herbal composition (Fufang Xueshuantong Capsule

复方血栓通胶囊

FXC)inischemicinischemic) in ischemic retinal disease. Methods: Fifteen adult male Sprague-Dawley rats underwent laser photothrombosis to induce RVO on their right eyes and were subsequently randomized to receive FXC (the intervention group

n=7) or placebo treatment (the control group

n=8). Fundus fluorescein angiography was performed after 2

4 and 8 weeks of treatment. Real-time reverse transcription-PCR was used to quantify the mRNA expression of vascular endothelial growth factor (VEGF) and stromal cell-derived factor-1 (SDF-1). The main outcomes were the mRNA copies of VEGF and SDF-1 and the counts of RVO signs. Laser photothrombosis procedure induced typical lesions of RVO

including hemorrhage

leakage

retinal detachment

capillary non-perfusion

filling defect of retinal vessels

and lateral circulation/dilation of small vessels. The retinal lesions were associated with an increased expression of VEGF (P<0.05). No significant change of SDF-1 expression was noticed. Compared with the control group

the intervention group had numerically fewer RVO lesions at week 2 (1.71±0.76 vs. 3.50±1.51

t=−2.82

P<0.05). The benefit of intervention remained at weeks 4 and 8. A rat model of laser photothrombosis-induced RVO was established and an increase in the VEGF expression was observed in the retinal lesion. The FXC had therapeutic benefit in improving retinal lesions in the rat model of RVO.

Abstract

To establish a retinal vein occlusion (RVO) animal model and observe the therapeutic effect of a Chinese herbal composition (Fufang Xueshuantong Capsule

复方血栓通胶囊

n=7) or placebo treatment (the control group

n=8). Fundus fluorescein angiography was performed after 2

including hemorrhage

leakage

retinal detachment

capillary non-perfusion

filling defect of retinal vessels

the intervention group had numerically fewer RVO lesions at week 2 (1.71±0.76 vs. 3.50±1.51

t=−2.82

关键词

Fufang Xueshuantong Capsuleretinal vein occlusionanimal modelstromal cell-derived factor-1vascular endothelial growth factor

Keywords

Fufang Xueshuantong Capsuleretinal vein occlusionanimal modelstromal cell-derived factor-1vascular endothelial growth factor

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