Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B

Wen-juan Liu; Yong-hua Zhang; Hai-yin Jiang

doi:10.1007/s11655-011-0708-0

Your Location：

Home >

Browse articles >

Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B

Updated：2021-08-27

- Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B
- Chinese Journal of Integrative Medicine Vol. 17, Issue 4, Pages: 302-306(2011)
- Affiliations：
  
  1. Zhejiang Chinese Medical University,Hangzhou,China
  2. The Seventh People’s Hospital of Hangzhou City,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0708-0
  CLC：
- Published：2011，
  
  Published Online：21 April 2011，
Scan for full text
Liu, Wj., Zhang, Yh. & Jiang, Hy. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B., Chin. J. Integr. Med. 17, 302 (2011). https://doi.org/10.1007/s11655-011-0708-0

Wen-juan Liu, Yong-hua Zhang, Hai-yin Jiang. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B. [J]. Chinese Journal of Integrative Medicine 17(4):302-306(2011)
Liu, Wj., Zhang, Yh. & Jiang, Hy. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B., Chin. J. Integr. Med. 17, 302 (2011). https://doi.org/10.1007/s11655-011-0708-0 DOI：

Wen-juan Liu, Yong-hua Zhang, Hai-yin Jiang. Relationship of anxiety state with lymphocyte subsets and the effect of chinese medical treatment on anxiety in patients with chronic hepatitis B. [J]. Chinese Journal of Integrative Medicine 17(4):302-306(2011) DOI： 10.1007/s11655-011-0708-0.

摘要

To analyze the relationship of anxiety state with CD4+ level and CD4+/CD8+ ratio and to observe the effect of Chinese medicine (CM) treatment on anxiety in chronic hepatitis B (CHB) patients. The anxiety state of 120 CHB patients was evaluated based on Hamilton Anxiety Scale (HAMA) scoring. According to the scores

63 patients with scores ≥14 were classified to anxiety and 57 patients with scores <14 to non-anxiety. The differences in CD4+ cells and CD4+/CD8+ ratio between patients with anxiety and non-anxiety were analyzed. Moreover

63 patients with anxiety were randomized into two groups: 31 in the control group were treated with lamivudine (100 mg per day) alone and 32 in the observation group were given equal dosage lamivudine combined with CM treatment depending on syndrome differentiation

all for 12 weeks. The effects of treatment on anxiety state and T-lymphocyte subsets as well as its impact on some CHB-related indices were observed and compared. The anxiety state of CHB patients was negatively correlated with CD4+ and CD4+/CD8+; the level of CD4+ in patients with anxiety was significantly lower than that in non-anxiety patients (P<0.01 or P<0.05). After treatment

anxiety state in the observation group was significantly improved

with their HAMA scores significantly lowered (P<0.01)

and the levels of CD4+ and CD4+/CD8+ were significantly higher than those in the control group (P<0.05 or P<0.01). Moreover

the alanine transaminase recovery rate and the HBV-DNA-negative conversion rate in the observation group were significantly higher than those in the control group

respectively (P<0.05). The anxiety state of CHB patients was related to CD4+ and CD4+/CD8+ levels. CM treatment could improve the anxiety state and showed certain regulatory effect on the patients’ immune system.

Abstract

anxiety state in the observation group was significantly improved

with their HAMA scores significantly lowered (P<0.01)

and the levels of CD4+ and CD4+/CD8+ were significantly higher than those in the control group (P<0.05 or P<0.01). Moreover

the alanine transaminase recovery rate and the HBV-DNA-negative conversion rate in the observation group were significantly higher than those in the control group

关键词

chronic hepatitis Banxiety stateimmuneChinese Medicine

Keywords

chronic hepatitis Banxiety stateimmuneChinese Medicine

references

Wang CH, Cong Z, eds. Clinical Psychotherapy. Beijing: People’s Military Medical Press; 2002:501–502.

Zhang JB, Huang XB, Guan NH, Tao J, Wang XL, Wei QL, et al. A controlled study of serum immunological, endocrinological and monoamine transmitter levels in patients with generalized anxiety disorder and major depression. Chin J Psychiatry (Chin) 2004;37:211–214.

Chinese Society of Hepatology and Chinese Society of Infectious Diseases, Chinese Medical Association. The guideline for prevention and treatment of chronic hepatitis B. Chin J Hepatol (Chin) 2005;13:881–891.

Chinese Society of Infectious and Parasitology Diseases, Chinese Society of Hepatology, Chinese Medical Association. Preventive and therapeutic program of viral hepatitis. Chin J Intern Med (Chin) 2001;40:62–68.

Zhang XR, Wang G, Hu L, Wang J, Chen DF. Clinical characteristics and psychotropic therapy of depression and anxious symptoms of patients with HBV infection. Chin J Hepatol (Chin) 2002;10:192.

Chen XB, Yang LH. Anxiety and depression in patients with viral hepatitis. Natl Med J China (Chin) 2002,82:398–399.

Zavala F. Benzodiazepines, anxiety and immunity. Pharmacol Ther 1997;75:199–216.

Battaglia M, Ogliari A. Anxiety and panic: from human studies to animal research and back. Neurosci Biobehav Rev 2005;29:169–179.

Yong EA, Veldhuis JD. Disordered adrenocorticotropin secretion in women with major depression. J Clin Endocrinol Metab 2006;91:1924–1928.

Chen HZ, ed. Practice of internal medicine (11th ed). Beijing: People’s Medical Publishing House; 2001:315.

Tian Y, Qiu ZF, Li TS. Difference and significance of peripheral blood T-lymphocyte subsets in patients with chronic hepatitis B and asymptomatic HBV carriers. Natl Med J China (Chin) 2005;85:3354–3358.

Gong JJ, Zhou YQ, Wu KN, Xu W. Study on the change and correlation between psychosocial factor and immunity function in breast cancer patients. Chin Gen Practice (Chin) 2008;11:838–840.

Wang H, Zhu H, Li Bei, Wang XW. Study on the change and correlation between psychology and immunity function in lung cancer patients. Chin J Behav Med Sci (Chin) 2005;14:320–321.

FULL TEXT LINK

More>

Views

775

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Chinese medicine for treatment of chronic hepatitis B

Fighting against acquired immunodeficiency syndrome with Chinese medicine: A perspective from China

Key symptoms selection for two major syndromes diagnosis of Chinese medicine in chronic hepatitis B

Future view and development of immunology: Exploring the immunology based on Chinese medicine and culture

Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients

Related Author

No data

Related Institution

Carolinas Medical Center

Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Institute of Liver Disease, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine

School of Life Sciences and Technology, Tongji University

institute of Shanghai Municipal Education Commission, Shanghai

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰