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Phytochemical analysis of medicinal plants with kidney protective activities
- Chinese Journal of Integrative Medicine Vol. 18, Issue 10, Pages: 790-800(2012)
- Affiliations：
1. Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California,Los Angeles,USA
2. Department of Chemistry & Biochemistry, University of California,Los Angeles,USA
3. Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona,USA
- Author bio：
- Funds：
DOI：10.1007/s11655-011-0713-3
CLC：Published：2012，
Published Online：26 April 2011，
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Lien, E.Jc., Lien, L.Lm., Wang, R. et al. Phytochemical analysis of medicinal plants with kidney protective activities., Chin. J. Integr. Med. 18, 790–800 (2012). https://doi.org/10.1007/s11655-011-0713-3
Eric Jung-chi Lien, Linda Lin-min Lien, Rubin Wang, et al. Phytochemical analysis of medicinal plants with kidney protective activities. [J]. Chinese Journal of Integrative Medicine 18(10):790-800(2012)
Lien, E.Jc., Lien, L.Lm., Wang, R. et al. Phytochemical analysis of medicinal plants with kidney protective activities., Chin. J. Integr. Med. 18, 790–800 (2012). https://doi.org/10.1007/s11655-011-0713-3 DOI：
Eric Jung-chi Lien, Linda Lin-min Lien, Rubin Wang, et al. Phytochemical analysis of medicinal plants with kidney protective activities. [J]. Chinese Journal of Integrative Medicine 18(10):790-800(2012) DOI： 10.1007/s11655-011-0713-3.
摘要
In view of the increasing number of patients undergoing kidney dialysis or transplant every year
a survey of the literature on renal protective medicinal plants was undertaken. Most of them are from traditional Chinese medicine (TCM). Although many of the medicinal herbs reported have not been investigated in terms of active chemical ingredients
some do have compounds well characterized. They fall into a wide range of structures. Several groups of compounds with well established activities are discussed. These include: antioxidant phenolic compounds like tannins
flavonoids
isoflavonoids
unsaturated organic acids and lignans; circulation enhancing compounds like saponins
and basic alkaloids with multiple targets (G-protein coupled receptors). Also presented are proinflammatory and antiinflammatory fatty acids like linoleic (n-6) and α-linolenic (n-3) acids
respectively. Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug discovery and development
and more rational application of TCM.
Abstract
In view of the increasing number of patients undergoing kidney dialysis or transplant every year
a survey of the literature on renal protective medicinal plants was undertaken. Most of them are from traditional Chinese medicine (TCM). Although many of the medicinal herbs reported have not been investigated in terms of active chemical ingredients
some do have compounds well characterized. They fall into a wide range of structures. Several groups of compounds with well established activities are discussed. These include: antioxidant phenolic compounds like tannins
flavonoids
isoflavonoids
unsaturated organic acids and lignans; circulation enhancing compounds like saponins
and basic alkaloids with multiple targets (G-protein coupled receptors). Also presented are proinflammatory and antiinflammatory fatty acids like linoleic (n-6) and α-linolenic (n-3) acids
respectively. Attention is also drawn to the plants containing nephrotoxic aristolochic acid. Different directions of future research are also presented. We hope that this review may provide some leads for new drug discovery and development
and more rational application of TCM.
关键词
kidney protective herbskidney protection natural productsantioxidantsfree radical scavengersimmunomodulating agentsantiinflammatory agentsstructure-activity relationshipphysicochemical parameters
Keywords
kidney protective herbskidney protection natural productsantioxidantsfree radical scavengersimmunomodulating agentsantiinflammatory agentsstructure-activity relationshipphysicochemical parameters
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