A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome

Song-ling Chu; Hong Fu; Jin-xia Yang; Geng-xin Liu; Pan Dou; Liang Zhang; Peng-fei Tu; Xue-mei Wang

doi:10.1007/s11655-011-0781-4

Your Location：

Home >

Browse articles >

A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome

Updated：2021-08-27

- A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome
- Chinese Journal of Integrative Medicine Vol. 17, Issue 7, Pages: 492-498(2011)
- Affiliations：
  
  1. Integration of Chinese and Western Medicine Laboratory of the First Hospital, Graduate School of Integration of Chinese and Western Medicine, Beijing Medical University,Beijing,China
  2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Major Project of Development of Biotic Resources in Yunnan Province (No. 2007YNCXB-01-01)
- DOI：10.1007/s11655-011-0781-4
  CLC：
- Published：2011，
  
  Published Online：3 July 2011，
Scan for full text
Chu, Sl., Fu, H., Yang, Jx. et al. A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome., Chin. J. Integr. Med. 17, 492–498 (2011). https://doi.org/10.1007/s11655-011-0781-4

Song-ling Chu, Hong Fu, Jin-xia Yang, et al. A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome. [J]. Chinese Journal of Integrative Medicine 17(7):492-498(2011)
Chu, Sl., Fu, H., Yang, Jx. et al. A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome., Chin. J. Integr. Med. 17, 492–498 (2011). https://doi.org/10.1007/s11655-011-0781-4 DOI：

Song-ling Chu, Hong Fu, Jin-xia Yang, et al. A randomized double-blind placebo-controlled study of Pu’er tea (普洱茶) extract on the regulation of metabolic syndrome. [J]. Chinese Journal of Integrative Medicine 17(7):492-498(2011) DOI： 10.1007/s11655-011-0781-4.

摘要

To explore the regulative efficacy of Pu’er tea (普洱茶) extract on metabolic syndrome. Ninety patients with metabolic syndrome were randomly divided into two groups

the intervention group administered with Pu’er tea extract

and the placebo group with placebo capsules. After 3 months’ treatment

body mass index

waist hip ratio

blood lipids

blood sugar

immune and inflammatory index

and oxidation index of the patients with metabolic syndrome were tested and analyzed. In the intervention group

the body mass index

waist-hip ratio

fasting and 2 h postprandial blood glucose

serum total cholesterol

triglycerides

low density lipoprotein and apolipoprotein B-100 all decreased in the patients with metabolic syndrome

and also the high-density lipoprotein level increased and apolipoprotein A-1 showed the tendency to increase. Serum C-reactive protein

tumor necrosis factor-α

and interleukin-6 were decreased in the intervention group. Interleukin-10 level was increased

MDA was decreased and superoxide dismutase was increased. Compared with before treatment and the placebo group

there were significant differences (P<0.05

P<0.01). Pu’er tea demonstrated excellent potential in improving central obesity

adjusting blood lipid

lowering blood sugar

regulating immunity and resisting oxidation. It can adjust the metabolic syndrome of different clinical phenotypes to different degrees

and is ideally fit for early prevention of metabolic syndrome.

Abstract

To explore the regulative efficacy of Pu’er tea (普洱茶) extract on metabolic syndrome. Ninety patients with metabolic syndrome were randomly divided into two groups

the intervention group administered with Pu’er tea extract

and the placebo group with placebo capsules. After 3 months’ treatment

body mass index

waist hip ratio

blood lipids

blood sugar

immune and inflammatory index

and oxidation index of the patients with metabolic syndrome were tested and analyzed. In the intervention group

the body mass index

waist-hip ratio

fasting and 2 h postprandial blood glucose

serum total cholesterol

triglycerides

low density lipoprotein and apolipoprotein B-100 all decreased in the patients with metabolic syndrome

and also the high-density lipoprotein level increased and apolipoprotein A-1 showed the tendency to increase. Serum C-reactive protein

tumor necrosis factor-α

and interleukin-6 were decreased in the intervention group. Interleukin-10 level was increased

MDA was decreased and superoxide dismutase was increased. Compared with before treatment and the placebo group

there were significant differences (P<0.05

P<0.01). Pu’er tea demonstrated excellent potential in improving central obesity

adjusting blood lipid

lowering blood sugar

regulating immunity and resisting oxidation. It can adjust the metabolic syndrome of different clinical phenotypes to different degrees

and is ideally fit for early prevention of metabolic syndrome.

关键词

teametabolic syndromerandomized controlled clinical study

Keywords

teametabolic syndromerandomized controlled clinical study

references

Wang PS, Liang MZ. Foretime and now of Pu’er tea. Tropical Agricultural Sci Technol (Chin) 2001;24(4):23–27.

Metabolic Syndrome Study Group of Diabetes Branch of Chinese Medical Association. Recommendations on the metabolic syndrome of Diabetes Branch of Chinese Medical Association. Chin J Diabetes (Chin) 2004;12:156–160.

Eckle RH, Grundy SM, Zimmet PZ. The metabolism syndrome. Lancet 2005;365:1415–1428.

Gu D, Reynolds K, Wu X, Chen J, Duan X, Reynolds RF, et al. Prevalence of the metabolism syndrome and overweight among adult in China. Lancet 2005;365:1398–1405.

Xiao YX. Recognition and therapeutic thoughts on metabolism syndrome. Chin J Basic Med Tradit Chin Med (Chin) 2007;13:538–539.

Li XJ, Liu ZL. Discussion on treatment of metabolism syndrome from spleen. Guiding J Tradit Chin Med Pharmacol (Chin) 2006;12(4): 9–10.

Yuan HB, Zhong J, Yi J, Zhao Y, Cao J. Tea extract on diet-induced obese rats lipogenic gene expression. Acta Nutrimenta Sin (Chin) 2009;31:167–171.

Jiang XF, Shao WF, Hou Y. Study on the function of preventing the hyperlipidemia lipid level and the antioxidant of the Pu’er tea. J Yunnan Agricultural Univ (Chin) 2009;24:705–711.

Zhou BX, Kong LB, Chen JX. Study on extraction of Pu’er tea polysaccharides and hypoglycemic. Chin Agricultural Sci Bull (Chin) 2009;25(15):55–59.

Wellen KE, Hotamisliglil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 2003;112:1785–1788.

Cardoso-Saldaña G, Juárez-Rojas JG, Zamora-González J, Raygoza-Pérez M, Martinez-Alvarado R, Posadas-Sánchez R, et al C-reactive protein levels and their relationship with metabolic syndrome and insulin resistance in Mexican adolescents. J Pediatr Endocrinol Metab 2007;20:797–805.

Kraja AT, Province MA, Arnett D, Wagenknecht L, Tang WH, Hopkins PN, et al. Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster. Nutr Metab (Lond) 2007;4:28.

Ferrari R, Ceconi C, Curello S, Cargnoni A, Alfieri O, Pardini A, et al. Oxygen free radicals and myocardial damage: protective role of thiol-containing agents. Am J Med 1991;91(3C):95S–105S.

Hatori N, Sjöquist PO, Marklund SL, Pehrsson SK, Rydén L. Effects of recombinant human extracellular-superoxide dismutase type C on myocardial reperfusion injury in isolated cold-arrested rat hearts. Free Radic Biol Med 1992;13:137–142.

Lee KU. Oxidative stress markers in Korean subjects with insulin resistance syndrome. Diabetes Res Clin Pract 2001; 54(Suppl 2):S29–S33.

Yang AF, Liu MY, Wang CQ, Ding HY, Xie XL, Xu YM, et al. Metabolic syndrome patients with oxidation — index changes of platelet aggregation. J Cardiovas Pulmonary Dis (Chin) 2004;23:228–230.

FULL TEXT LINK

More>

Views

892

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

A systematic analysis of the theory and practice of syndrome differentiation

Extracts of monascusus purpureus beyond statins —Profile of efficacy and safety of the use of extracts of monascus purpureus

Related Author

No data

Related Institution

.NA.., Crocetta del Montello (TV)

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰