Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

Ba-si Ouyang; Jie Gao; Jian-li Che; Yin Zhang; Jun Li; Hai-zhou Yang; Tian-yan Hu; Man Yang; Yuan-jian Wu; Ling-ling Ji

doi:10.1007/s11655-011-0783-2

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Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis

Updated：2021-08-27

- Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis
- Chinese Journal of Integrative Medicine Vol. 17, Issue 7, Pages: 505-509(2011)
- Affiliations：
  
  1. Suzhou Hospital of Traditional Chinese Medicine,Jiangsu Province,Suzhou,China
  2. First Affiliated Hospital of Soochow University,Jiangsu Province,Suzhou,China
  3. Children’s Hospital of Soochow University,Jiangsu Province,China
  4. Nanjing University of Traditional Chinese Medicine,Nanjing,China
- Author bio：
- Funds：
  
  Supported by the Suzhou Municipal Developing Plan of Sciences and Technology (Social Development and Three-drug Keystone, No. SS0528)
- DOI：10.1007/s11655-011-0783-2
  CLC：
- Published：2011，
  
  Published Online：3 July 2011，
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Ouyang, Bs., Gao, J., Che, Jl. et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 505–509 (2011). https://doi.org/10.1007/s11655-011-0783-2

Ba-si Ouyang, Jie Gao, Jian-li Che, et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis. [J]. Chinese Journal of Integrative Medicine 17(7):505-509(2011)
Ouyang, Bs., Gao, J., Che, Jl. et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 505–509 (2011). https://doi.org/10.1007/s11655-011-0783-2 DOI：

Ba-si Ouyang, Jie Gao, Jian-li Che, et al. Effect of electro-acupuncture on tumor necrosis factor-α and vascular endothelial growth factor in peripheral blood and joint synovia of patients with rheumatoid arthritis. [J]. Chinese Journal of Integrative Medicine 17(7):505-509(2011) DOI： 10.1007/s11655-011-0783-2.

摘要

To observe the effect of electro-acupuncture (EA) on tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in peripheral blood and joint synovia in patients with rheumatoid arthritis (RA) to verify the clinical efficacy of EA. Adopting randomized controlled principle

the 63 RA patients enrolled were assigned to two groups

the 32 patients in the EA group were treated with EA

and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method

the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day

10 times as a course

and each patient received a total of 3 courses of treatment. Blood and synovial levels of TNF-α and VEGF were reduced significantly after treatment in both groups. The lowering (absolute value and difference value) of TNF-α as well as the absolute value of VEGF

either in blood or in synovia

were similar in the two groups (P>0.05); but the lowering of VEGF after treatment was more significant in the EA group than that in the SN group (P<0.05). EA could effectively lower the contents of TNF-α and VEGF in peripheral blood and joint synovia to improve the internal environment for genesis and development of RA

so as to enhance the clinical therapeutic effectiveness.

Abstract

the 63 RA patients enrolled were assigned to two groups

the 32 patients in the EA group were treated with EA

and the 31 patients in the simple needling (SN) group treated with simple needling. According to the integral-local combining method

the acupoints were selected mainly from yang-meridian and local Ashi points (pain-point). EA or SN was applied every other day

10 times as a course

either in blood or in synovia

so as to enhance the clinical therapeutic effectiveness.

关键词

electro-acupunctureneedlingrheumatoid arthritistumor necrosis factorvascular endothelial growth factor

Keywords

electro-acupunctureneedlingrheumatoid arthritistumor necrosis factorvascular endothelial growth factor

references

Henderson B. Arthritogenic actions of recombinant IL-1 and tumor necrosis factor α in the rabbit: evidence for synergistic interactions between cytokine in vivo. Clin Exp Immonol 1989;75:306–310.

Li SF. Levels and significance of TNF-α in peripheral blood and synovial fluid form patients with rheumatoid arthritis. Henan Med Res (Chin) 2007;16(1):59–60, 69.

Xie JM, Yu BY, Lu CS. Expression of vascular endothelial cell growth factor and its up-regulation of matrix metalioproteinase-2 activation in synovial fluid of patients with rheumatoid arthritis. Chin J Rheumatol (Chin) 2006;10:495–497.

Tang HH, Feng ZJ, Guo XH. Pathogenesis of IL-6 and TNF-α in the rheumatoid arthritis. Chin J Rheumatol (Chin) 1998;2:236–238.

Lipsky PE, van der Heijde DM, St Clair EW, Furst DE, Breedveld FC, Kalden JR, et al. Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group. N Engl J Med 2000;343:1594–1602.

Wand CH, Chen LN, Zhu P, Fan CM, Wang YH, Jia JF. CD147 stimulates the angiogenesis in rheumatoid synovium via the activation of vascular endothelial growth factor. J Cell Mol Immunol (Chin) 2007;23:426–428.

Amett FC, Edworthy SM, Bloch DA. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–324.

Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, et al. American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum 1995;38:727–735.

Redich KP, Hayen S, Ricct R. Ostecolasts are essential for INF-mediated joint destruction. Arthritis Res 2002;4(Suppl):S45–S47.

Xie JM, Wang HW, Lu CS. Association of TNF-α upregulation of MMP-9 activation in monocyte-derived macrophages with progression of joint damage in patients with rheumatoid arthritis. Chin J Pathophysiol (Chin) 2009;25:1181–1185.

Nagashima M, Asano G, Yoshino S. Imbalance in production between vascular endothelial growth factor and endostatin in patients with rheumatoid arthritis. J Rheumatol 2000;27:2339–2342.

Macias I, Garcia PS, Ruiz-T M. Modification of pro- and anti-inflammatory cytokines and vascular-related molecules by tumor necrosis factor-α blockade in patients with rheumatoid arthritis. Rheumatol 2005;32:2102–2108.

Mikuls T, Mereland L. Predicting outcomes in early rheumatoid arthritis. Curr Rheumatol Rep 2002;4:193–194.

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