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Protective effects of the preconditioning with different doses of sodium aescinate on tourniquet-induced ischemic reperfusion
- Chinese Journal of Integrative Medicine Vol. 17, Issue 7, Pages: 542-545(2011)
- Affiliations：
Department of Anesthesiology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine,Nanjing,China
- Author bio：
- Funds：
DOI：10.1007/s11655-011-0789-9
CLC：Published：2011，
Published Online：3 July 2011，
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Yang, G., Cui, Sy. & Huang, Lb. Protective effects of the preconditioning with different doses of sodium aescinate on tourniquet-induced ischemic reperfusion., Chin. J. Integr. Med. 17, 542–545 (2011). https://doi.org/10.1007/s11655-011-0789-9
Guang Yang, Su-yang Cui, Li-bing Huang. Protective effects of the preconditioning with different doses of sodium aescinate on tourniquet-induced ischemic reperfusion. [J]. Chinese Journal of Integrative Medicine 17(7):542-545(2011)
Yang, G., Cui, Sy. & Huang, Lb. Protective effects of the preconditioning with different doses of sodium aescinate on tourniquet-induced ischemic reperfusion., Chin. J. Integr. Med. 17, 542–545 (2011). https://doi.org/10.1007/s11655-011-0789-9 DOI：
Guang Yang, Su-yang Cui, Li-bing Huang. Protective effects of the preconditioning with different doses of sodium aescinate on tourniquet-induced ischemic reperfusion. [J]. Chinese Journal of Integrative Medicine 17(7):542-545(2011) DOI： 10.1007/s11655-011-0789-9.
摘要
To evaluate the protective effects of sodium aescinate (SA) preconditioning on the tourniquet-induced ischemia-reperfusion (I/R) injury after limbs operation. Seventy-five patients with grade I–II issued by American Society of Anesthesiology undergoing lower limb operation were randomly assigned to 3 groups: the control group
low-dose SA-treated group and high-dose SA-treated group; each group enrolled 25 patients. The patients were treated with 5 mg and 10 mg SA 30 min before tourniquet inflation in the two treatment groups separately
while the patients in the control group received normal saline. Venous blood samples were obtained before tourniquet was inflated (T0 baseline). And 5 (T1)
10 (T2)
20 (T3) min after tourniquet was released. The nitric oxide (NO)
malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined by commercial kits. Meanwhile
arterial pressure (MAP) and heart rate (HR) were monitored from an automatic invigilator. In the control group
MDA and NO levels were increased
and SOD and MAP were decreased significantly after tourniquet deflation compared to T0 baseline (P<0.05). After tourniquet deflation
MDA and NO levels in the two treated groups were significantly decreased; meanwhile
SOD levels and MAP were increased
and the variations of HR were more stable compared with the control group (all P<0.05). There was no significant difference in all of the above between the two treated groups (P>0.05). The protective effects of SA preconditioning on tourniquet-induced limb I/R injury might possibly contribute to the increasing of SOD levels
and MAP and the decreasing of MDA and NO levels.
Abstract
To evaluate the protective effects of sodium aescinate (SA) preconditioning on the tourniquet-induced ischemia-reperfusion (I/R) injury after limbs operation. Seventy-five patients with grade I–II issued by American Society of Anesthesiology undergoing lower limb operation were randomly assigned to 3 groups: the control group
low-dose SA-treated group and high-dose SA-treated group; each group enrolled 25 patients. The patients were treated with 5 mg and 10 mg SA 30 min before tourniquet inflation in the two treatment groups separately
while the patients in the control group received normal saline. Venous blood samples were obtained before tourniquet was inflated (T0 baseline). And 5 (T1)
10 (T2)
20 (T3) min after tourniquet was released. The nitric oxide (NO)
malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined by commercial kits. Meanwhile
arterial pressure (MAP) and heart rate (HR) were monitored from an automatic invigilator. In the control group
MDA and NO levels were increased
and SOD and MAP were decreased significantly after tourniquet deflation compared to T0 baseline (P<0.05). After tourniquet deflation
MDA and NO levels in the two treated groups were significantly decreased; meanwhile
SOD levels and MAP were increased
and the variations of HR were more stable compared with the control group (all P<0.05). There was no significant difference in all of the above between the two treated groups (P>0.05). The protective effects of SA preconditioning on tourniquet-induced limb I/R injury might possibly contribute to the increasing of SOD levels
and MAP and the decreasing of MDA and NO levels.
关键词
ischemic reperfusion injurysodium aescinatelimb
Keywords
ischemic reperfusion injurysodium aescinatelimb
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