A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)

Quan Jiang; Xin-yao Zhou; Lei Wang; Wei Yu; Ping Wang; Wei Cao; Xiao-po Tang

doi:10.1007/s11655-011-0793-0

Your Location：

Home >

Browse articles >

A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)

Updated：2021-08-27

- A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)
- Chinese Journal of Integrative Medicine Vol. 18, Issue 4, Pages: 256-261(2012)
- Affiliations：
  
  1. School of Rehabilitation Medicine, Fujian University of Traditional Chinese Medicine,Fuzhou,China
  2. Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  3. Department of Radiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  4. Department of Radiology, Beijing Union Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by Capital Development Fund for Medical Research (No. 2005-SF-I-010)
- DOI：10.1007/s11655-011-0793-0
  CLC：
- Published：2012，
  
  Published Online：18 August 2011，
Scan for full text
Jiang, Q., Zhou, Xy., Wang, L. et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)., Chin. J. Integr. Med. 18, 256–261 (2012). https://doi.org/10.1007/s11655-011-0793-0

Quan Jiang, Xin-yao Zhou, Lei Wang, et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方). [J]. Chinese Journal of Integrative Medicine 18(4):256-261(2012)
Jiang, Q., Zhou, Xy., Wang, L. et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方)., Chin. J. Integr. Med. 18, 256–261 (2012). https://doi.org/10.1007/s11655-011-0793-0 DOI：

Quan Jiang, Xin-yao Zhou, Lei Wang, et al. A one-year evaluation of radiographic progression in patients with rheumatoid arthritis treated by Qingre Huoxue Decoction (清热活血方). [J]. Chinese Journal of Integrative Medicine 18(4):256-261(2012) DOI： 10.1007/s11655-011-0793-0.

摘要

To investigate the effects of Qingre Huoxue Decoction 清热活血方

clearing heat and promoting blood flow; QRHXD)

on the radiographic progression in patients with rheumatoid arthritis (RA) by X-ray imaging. Eighty-six patients with active RA diagnosed as damp-heat and blood stasis syndrome were randomized into a QRHXD group and a QRHXD plus methotrexate (MTX) group

with 43 cases in each group. After one-year of treatment

21 cases in each group (42 in total) were evaluated. Radiographs of hands were obtained at the baseline and after 12 months of treatment. Images were evaluated by investigators blinded to chronology and clinical data

and assessed according to the Sharp/Van der Heijde methods. High intrareader agreements were reached (mean intraobserver intraclass coefficients: 0.95). No significant change in any imaging parameters of joint destruction was observed at 12 months in either group; and the differences between the two groups were not significant (P>0.05). The mean of the changing score in the QRHXD group was 3.5±4.1

and 2.4±3.5 in the QRHXD+MTX group

while the baseline radiographic score of patients in the QRHXD group was relatively higher (18.9±19.1 vs. 14.0±14.0). The mean rates of the changing scores of the two groups were similar (0.24±0.28 vs. 0.25±0.44

P=0.40). The severity of progression in the two groups was also similar (P=0.46)

7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD+MTX group

3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD+MTX group. Radiographic progression of RA patients in both groups is similar

indicating that the QRHXD Decoction has a potential role in preventing bone destruction.

Abstract

To investigate the effects of Qingre Huoxue Decoction 清热活血方

clearing heat and promoting blood flow; QRHXD)

with 43 cases in each group. After one-year of treatment

and 2.4±3.5 in the QRHXD+MTX group

P=0.40). The severity of progression in the two groups was also similar (P=0.46)

7 cases without radiographic progression in the QRHXD group and 8 in the QRHXD+MTX group

3 cases with obvious radiographic progression in the QRHXD group and 1 in the QRHXD+MTX group. Radiographic progression of RA patients in both groups is similar

indicating that the QRHXD Decoction has a potential role in preventing bone destruction.

关键词

rheumatoid arthritisQingre Huoxue DecoctionChinese Medicineherbradiologybone destruction

Keywords

rheumatoid arthritisQingre Huoxue DecoctionChinese Medicineherbradiologybone destruction

references

Firestein G, Panayi G, Wollheim FA. Rheumatoid arthritis. 2nd ed. Oxford: Oxford University Press; 2006:3–14.

Norfolk Arthritis Register, St Michael’s Hospital, Aylsham, Norfolk. The impact of rheumatoid arthritis on employment status in the early years of disease: a UK community-based study. Rheumatology (Oxford) 2000;39:1403–1409.

Jiang Q, Cao W, Tang XP, Mu XZ, Jiao J. Clinical efficacy research of Qingre Huoxue Formula in the treatment of rheumatoid arthritis at the active stage. World J Integr Tradit West Med (Chin) 2010;7:588–592.

Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315–32

Zheng XY. Guiding principle of clinical research on new drugs of traditional Chinese medicine. Beijing: China Medic-Pharmaceutical Sciences and Technology Publishing House; 2002:115–119.

Fransen J, Riel PL. The disease activity score and the EULAR response criteria. Clin Exp Rheumatol 2005;23(Suppl39):S93–S99.

Desiree MFM, van der Heijde D. Plain X-rays in rheumatoid arthritis: overview of scoring methods, their reliability and applicability. Baillikre’s Clin Rheumatol 1996;10:435–453.

Soubrier M, Puéchal X, Sibilia J, Mariette X, Meyer O, Combe B, et al. Evaluation of two strategies (initial methotrexate monotherapy vs its combination with adalimumab) in management of early active rheumatoid arthritis: data from the GUEPARD trial. Rheumatology 2009;48:1429–1434.

van der Heijde D, Kalden J, Scott D, Smolen J, Strand V. Long-term evaluation of radiographic disease progression in a subset of patients with rheumatoid arthritis treated with leflunomide beyond 2 years. Ann Rheum Dis 2004;63:737–739.

Sato K. Th17 cells and rheumatoid arthritis-from the standpoint of osteoclast differentiation. Allergol Int 2008;57:109–114.

FULL TEXT LINK

More>

Views

896

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?

The potential role of Chinese medicine in ameliorating extra-articular manifestations of rheumatoid arthritis

Clinical observation on methotrexate combined with chinese preparations in treating rheumatoid arthritis patients

Effect of Artemisia annua extract on treating active rheumatoid arthritis: A randomized controlled trial

Effects of agkistrodon in different dosage forms on collagen-induced arthritis in rats

Related Author

No data

Related Institution

Department of Rheumatism Immunity, First Affiliated Hospital, Anhui University of Chinese Medicine

Anhui University of Chinese Medicine

Department of Rheumatology, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine

Rheumatism Department, The Third Affiliated Hospital, Sun Yat-sen University of Medical Sciences

Department of Traditional Chinese Medicine, Rheumatology Center of Integrated Traditional and Western Medicine, General Hospital of Chengdu Military Area Command PLA

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰