Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease

Yue Liu; Hui-jun Yin; Ke-ji Chen

doi:10.1007/s11655-011-0814-z

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Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease

Updated：2021-08-27

- Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease
- Chinese Journal of Integrative Medicine Vol. 17, Issue 8, Pages: 587-592(2011)
- Affiliations：
  
  Department of Cardiovascular Disease, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81073086)
- DOI：10.1007/s11655-011-0814-z
  CLC：
- Published：2011，
  
  Published Online：9 August 2011，
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Liu, Y., Yin, Hj. & Chen, Kj. Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease., Chin. J. Integr. Med. 17, 587 (2011). https://doi.org/10.1007/s11655-011-0814-z

Yue Liu, Hui-jun Yin, Ke-ji Chen. Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease. [J]. Chinese Journal of Integrative Medicine 17(8):587-592(2011)
Liu, Y., Yin, Hj. & Chen, Kj. Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease., Chin. J. Integr. Med. 17, 587 (2011). https://doi.org/10.1007/s11655-011-0814-z DOI：

Yue Liu, Hui-jun Yin, Ke-ji Chen. Research on the correlation between platelet gelsolin and blood-stasis syndrome of coronary heart disease. [J]. Chinese Journal of Integrative Medicine 17(8):587-592(2011) DOI： 10.1007/s11655-011-0814-z.

摘要

To study the distribution of gelsolin in human platelet and plasma

and the association with blood-stasis syndrome (BSS) of coronary heart disease (CHD). Sixty patients with CHD (30 in BSS group and 30 in non-BSS group) and 30 healthy subjects (control group) were included in this study. The classification of the syndrome was based on clinical symptoms and signs. Gelsolin concentration in platelet rich plasma (PRP)

platelet poor plasma (PPP)

filamentous actin (F-actin) and group-specific component globulin (Gc-globulin) of PPP were determined by enzyme-linked immunosorbent assay (ELISA). The fluorescence intensity of CD62p and cytoplasmic calcium ([Ca2+]i) in human platelets of patients and healthy persons was measured with flow cytometry. Compared with the control group

gelsolin in PRP of the BSS group increased significantly (P<0.01)

while that in PPP of the BSS and non-BSS groups decreased markedly (P<0.05)

the CD62p

[Ca2+]i of platelet

F-actin

and Gc-globulin of the BSS and non-BSS groups increased significantly (P<0.01). Compared with the non-BSS group

the gelsolin concentration in PRP of BSS group increased significantly (P<0.01)

the [Ca2+]i of platelet of the BSS group increased markedly (P<0.01)

while the F-actin and Gc-globulin of the BSS group had no statistical defference (P>0.05). Gelsolin concentration in PRP was increased and accompanied by the elevated [Ca2+]i of platelet in CHD with BSS

while gelsolin in PPP were lowered markedly. We speculate that plasma gelsolin may clear F-actin from circulation

thus resulting in depletion of plasma gelsolin significantly. This

in addition to the increased calcium influx of platelets

may lead to the gelsolin abnormal expression on platelets during the process of BSS in CHD. Therefore

platelet gelsolin may serve as a new potential biomarker and a therapeutic target of BSS in CHD.

Abstract

To study the distribution of gelsolin in human platelet and plasma

platelet poor plasma (PPP)

gelsolin in PRP of the BSS group increased significantly (P<0.01)

while that in PPP of the BSS and non-BSS groups decreased markedly (P<0.05)

the CD62p

[Ca2+]i of platelet

F-actin

and Gc-globulin of the BSS and non-BSS groups increased significantly (P<0.01). Compared with the non-BSS group

the gelsolin concentration in PRP of BSS group increased significantly (P<0.01)

the [Ca2+]i of platelet of the BSS group increased markedly (P<0.01)

while gelsolin in PPP were lowered markedly. We speculate that plasma gelsolin may clear F-actin from circulation

thus resulting in depletion of plasma gelsolin significantly. This

in addition to the increased calcium influx of platelets

may lead to the gelsolin abnormal expression on platelets during the process of BSS in CHD. Therefore

platelet gelsolin may serve as a new potential biomarker and a therapeutic target of BSS in CHD.

关键词

gelsolinfilamentous actincoronary heart diseaseBlood Stasis Syndromeplatelet activation

Keywords

gelsolinfilamentous actincoronary heart diseaseBlood Stasis Syndromeplatelet activation

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Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Department of Cardiology, Guang’anmen Hospital

Academy of Chinese Medical Sciences

Xiyuan Hospital, China Academy of Chinese Medical Sciences

General Hospital of Jinan Military Region

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