Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Xin Mou; Wen-hong Liu; Dan-yang Zhou; Ying-hui Liu; Yong-bin Hu; Guo-ling Ma; Cheng-min Shou; Jia-wei Chen; Jin-xi Zhao

doi:10.1007/s11655-011-0845-5

Your Location：

Home >

Browse articles >

Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism

Updated：2021-08-27

- Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism
- Chinese Journal of Integrative Medicine Vol. 17, Issue 9, Pages: 680-684(2011)
- Affiliations：
  
  1. Department of Endocrinology of Hangzhou Red Cross Hospital,Hangzhou,China
  2. Zhejiang University of Chinese Medicine,Hangzhou,China
  3. Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30801467) and Zhejiang Provincial Natural Science Foundation of China (No. Y2080683)
- DOI：10.1007/s11655-011-0845-5
  CLC：
- Published：2011，
  
  Published Online：11 September 2011，
Scan for full text
Mou, X., Liu, Wh., Zhou, Dy. et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism., Chin. J. Integr. Med. 17, 680 (2011). https://doi.org/10.1007/s11655-011-0845-5

Xin Mou, Wen-hong Liu, Dan-yang Zhou, et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism. [J]. Chinese Journal of Integrative Medicine 17(9):680-684(2011)
Mou, X., Liu, Wh., Zhou, Dy. et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism., Chin. J. Integr. Med. 17, 680 (2011). https://doi.org/10.1007/s11655-011-0845-5 DOI：

Xin Mou, Wen-hong Liu, Dan-yang Zhou, et al. Association of Chinese medicine constitution susceptibility to diabetic nephropathy and transforming growth factor-β1 (T869C) gene polymorphism. [J]. Chinese Journal of Integrative Medicine 17(9):680-684(2011) DOI： 10.1007/s11655-011-0845-5.

摘要

To explore the association of Chinese medicine constitution susceptibility to diabetic nephropathy (DN) and transforming growth factor (TGF)-β1 (T869C) gene polymorphism. TGF-β1 gene polymorphism detected with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was screened for 180 DN cases and 180 type 2 diabetic mellitus (T2DM) cases without combined DN. Patients with DN were surveyed epidemiologically with constitution in the Chinese medicine questionnaire (CCMQ). Binary logistic regression analysis was utilized to study the correlation between nine types of Chinese medicine constitution and TGF-β1 (T869C) gene polymorphisms. The DN group has a higher frequency of TGF-β1 (T869C) gene polymorphism than the T2DM group

and CC/CT genotypes than the T2DM group [CC

TT (DN group): 88

5 (cases) versus (T2DM group) 71

36 (cases)

P<0.05]. The phlegm-dampness constitution

damp-heat constitution

and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism. Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism

a potential predictor of susceptibility to DN in T2DM patients.

Abstract

and CC/CT genotypes than the T2DM group [CC

TT (DN group): 88

5 (cases) versus (T2DM group) 71

36 (cases)

P<0.05]. The phlegm-dampness constitution

damp-heat constitution

and blood stasis constitution have correlations with TGF-β1 (T869C) gene polymorphism. Chinese medicine constitutions were associated with TGF-β1 (T869C) gene polymorphism

a potential predictor of susceptibility to DN in T2DM patients.

关键词

diabetic nephropathygene polymorphismtransforming growth factor-β1Chinese medicine constitution

Keywords

diabetic nephropathygene polymorphismtransforming growth factor-β1Chinese medicine constitution

references

Meetoo D, McGovern P, Safadi R. An epidemiological overview of diabetes across the world. Br J Nurs 2007; 16:1002–1007.

Robert C, Atkins, Paul Z. Diabetic kidney disease: act now or pay later. Arch Iran Med 2010;13:77–80.

Yang WY, Lu JM, Weng JP, Jia WP, Ji LN, Xiao J, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090–1101.

McDonald S, Excell L, Livingston B, ed. Appendix II, in ANZDATA (Australia and New Zealand dialysis and transplant ) registry report. 2008:499–518.

Yamagata K, Iseki K, Nittak K, Imai H, Iion Y, Matsuo S, et al. Chronic kidney disease perspectives in Japan and the importance of urinalysis screening. Clin Exp Nephrol 2008;12:1–8.

Lysaght M. Maintenance dialysis population dynamics: current trends and long term implications. J Am Soc Nephrol 2002;13:37–40.

The Chinese Diabetes Society of the Chinese Medical Association. China Guideline for Diabetes. Beijing: Peking University Medical Press; 2003:10.

Mogensen CE. Early diabetic renal involvelent and nephropathy. Amsterdan: Elsevier Science Publishers; 1987:306.

Wang Q, Zhu YB, Xue HS. Primary compiling of constitution in Chinese medicine questionnaire. Chin J Clin Rehabilt (Chin) 2006;10:12–14.

Zhu YB, Wang Q, Hideki O. Evaluation on reliability and validity of the constitution in Chinese medicine questionnaire (CCMQ). Chin J Behav Med Sci (Chin) 2007;16:651–653.

Mou X, Zhou DY, Zhao JX. Development methods of traditional Chinese medicine syndrome scale of diabetic nephropathy. China J Tradit Chin Med Pharm (Chin) 2007; 22:787–788.

Wang Q. On three key issues in the study on traditional Chinese medicine constitution (Latter). J Tradit Chin Med (Chin) 2006;47:329–331.

Wang XQ. The theory of “three yin and three yang” and the thinking of prevention and cure to diabetes mellitus. Chin Arch Tradit Chin Med (Chin) 2007;25:119–121.

Chen Z, Xu HW, Fu G, Huang W. The status and prospects of human genome project (Part II). Cap Med (Chin) 2000;7:4–6.

Qian HN. Study on traditional Chinese medicine constitution, genomics and proteomics. J Tradit Chin Med (Chin) 2003;44:167–169.

Roger MM, Nadia AW. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephro 2003;14:1358–1373.

Bayat A, Bock O, Mrowietz U, Ollier WE, Ferguson MW. Genetic susceptibility to keloid disease and hypertrophic scarring transforming growth factor beta 1 common polymorphisma and plasma levels. Plast Reconstr Surg 2003;11:534–543.

Wong TY, Poon P, Chow KM, Szeto CC, Cheun MK, Philip KTL, et al. Association of transforming growth factorbeta (TGF-beta) T869C (Leu10Pro) gene polymorphisms with type 2 diabctic nephropathy in Chinese. Kid Int 2003;63:1831–1835.

FULL TEXT LINK

More>

Views

770

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Study on the relationship between chinese medicine constitutive susceptibility and diversity of syndrome in diabetic nephropathy

Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats

Regulation of C-type natriuretic peptides and natriuretic peptide receptor-B expression in diabetic rats renal treated by Tongluo Recipe (通络方)

Effects of panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus

Chinese Medicine for Treating Diabetic Nephropathy

Related Author

No data

Related Institution

Zhejiang University of Traditional Chinese Medicine

Dongzhimen Hospital, Beijing University of Chinese Medicine

Department of Endocrinology, Hangzhou Red-Cross Hospital

Department of Pharmacy, College of Chemical and Chemistry Engineering, Hu’nan University

Department of Basic Guiyang College of Traditional Chinese Medicine

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰