Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome

Guo-lin Wu; Tian-yi Li; Yong-sheng Fan; Guo-you Yu

doi:10.1007/s11655-011-0850-8

Your Location：

Home >

Browse articles >

Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome

Updated：2021-08-27

- Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome
- Chinese Journal of Integrative Medicine Vol. 17, Issue 9, Pages: 710-714(2011)
- Affiliations：
  
  1. The First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou,China
  2. Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0850-8
  CLC：
- Published：2011，
  
  Published Online：11 September 2011，
Scan for full text
Wu, Gl., Li, Ty., Fan, Ys. et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome., Chin. J. Integr. Med. 17, 710 (2011). https://doi.org/10.1007/s11655-011-0850-8

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome. [J]. Chinese Journal of Integrative Medicine 17(9):710-714(2011)
Wu, Gl., Li, Ty., Fan, Ys. et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome., Chin. J. Integr. Med. 17, 710 (2011). https://doi.org/10.1007/s11655-011-0850-8 DOI：

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome. [J]. Chinese Journal of Integrative Medicine 17(9):710-714(2011) DOI： 10.1007/s11655-011-0850-8.

摘要

To observe the therapeutic effect of Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis on serum osteopontin (OPN) and quality of life (QOL) in patients with primary Sjogren's syndrome (pSS) and to study the correlation between OPN level and the disease. Sixty-eight pSS patients were randomly assigned to two groups: the treatment group (35 cases) treated by Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment

immunoglobulin G (IgG) level

erythrocyte sedimentation rate (ESR)

and OPN level were measured. The QOL in patients was evaluated using the Short Form-36 Health Survey (SF-36) before and after treatment. Thirty healthy females were taken as the normal control. Before treatment

levels of IgG

ESR

and OPN in patients were higher than those in the normal control. After 3 months of treatment

those in both treatment groups decreased but were lower in the treatment group than those in the control group (P<0.05). The scores of 8 dimensions of SF-36 were lower in the pSS patients than those in the normal control (P<0.05) and higher in the treatment group than in the control group after treatment (P<0.05). Furthermore

there was a positive correlation between the levels of OPN and the levels of IgG and ESR

and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis could alleviate pSS disease and improve the QOL. In addition

the OPN level might be used as an evaluating index for pSS disease.

Abstract

To observe the therapeutic effect of Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis combined with hydroxychloroquine sulfate tablet (HCQ) and the control group (33 cases) treated by HCQ only. Both were treated for 3 months. Before and after treatment

immunoglobulin G (IgG) level

erythrocyte sedimentation rate (ESR)

levels of IgG

ESR

and OPN in patients were higher than those in the normal control. After 3 months of treatment

there was a positive correlation between the levels of OPN and the levels of IgG and ESR

and a negative correlation between OPN levels and the overall score of SF-36 (P<0.05). Chinese herbal medicine for strengthening qi

nourishing yin

and removing stasis could alleviate pSS disease and improve the QOL. In addition

the OPN level might be used as an evaluating index for pSS disease.

关键词

primary Sjogren's syndromeChinese Herbal Medicinestrengthening qinourishing Yinremoving stasisquality of life

Keywords

primary Sjogren's syndromeChinese Herbal Medicinestrengthening qinourishing Yinremoving stasisquality of life

references

Zhao Y, Dong Y. The clinical picture of primary Sjogren'ls syndrome. Beijing Med (Chin) 1997;19:100–104.

Chiocchetti A, Indelicato M, Bensi T, Mesturini R, Giordano M, Sametti S, et al. High levels of osteopontin with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation. Blood 2004;103:1376–1382.

Zhao Y, Fei YY, Deng XX, Zhang PL, Gan XD, Shi YP, et al. Significance of anti-ot-fodrin antibody in the diagnosis of Sjoegren's syndrome and its correlation with clinical manifestations. Chin J Rheumatol (Chin) 2005;9:261–264.

Wu GL, Han YM, Fan YS, Yu GY. Effects of Chinese herbal medicine for Yiqi Yangyin Quyu in treating Sjoegren's syndrome and on patients immunologic function. Chin J Integr Tradit West Med (Chin) 2006;26:322–324.

Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, et al. Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002;61:554–558.

Wan CH, Fang JQ, Tang XL, Zhang CZ, Lu YB, Meng Q, et al. The effect evaluation on measuring quality of life in patients with liver cancer by SF-36 scale. Tumor (Chin) 2005;25:492–494.

Dawson LJ, Caulfield VL, Stanbury JB, Field AE, Christmas SE, Smith PM. Hydroxy chloroquine therapy in patients with primary Sjsgren's syndrome may improve salivary gland hypofunction by inhibition of glandular cholinesterase. Rheumatology (Oxford) 2005;44:449–455.

Blom T, Franzén A, Heinegård D, Holmdahl R. Comment on “The influence of the proinflammatory cytokine osteopontin on autoimmune demyelinating disease”. Science 2003;299:1845–1850.

Hummelshoj T, Ryder LP, Madsen HO, Odum N, Svejgaard A. A functional polymorphism in the Eta-1 promoter is associated with allele specific binding to the transcription factor SP1 and elevated gene expression. Mol Immunol 2006;43:980–986.

Stewart CM, Berg KM, Cha S, Reeves WH. Salivary dysfunction and quality of life in Sjogren syndrome: a critical oral-systemic connection. J Am Dent Assoc 2008;139:291–299;quiz 358–359.

Li XM, Duan LP, Wan CH, Zhou ZF, Pan JH, Yang Z, et al. Evaluation of SF-36 instrument with the quality of life in chronic diseases. China Med (Chin) 2006;1:645–648.

Ricci R, Quesada A, Pignalberi C, Roda J, Disertori M, Capucci A, et al. Dual defibrillator improves quality of life and decreases hospitalizations in patients with drug refractory atrial fibrillation. J Interv Card Electrophysiol 2004;10:85–92.

FULL TEXT LINK

More>

Views

764

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome

Effect of Chinese herbal medicines for nourishing yin, supplementing qi, and activating blood on reproductive endocrine activity and immune functions in patients with primary Sjogren’s syndrome

Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Development is a high level inheritance for China Time-honored Brand products

Effectiveness of Bufei Yishen Granule (补肺益肾颗粒) combined with acupoint sticking therapy on quality of life in patients with stable chronic obstructive pulmonary disease

Related Author

No data

Related Institution

The First Affiliated Hospital of Medical College of Zhejiang University

Zhejiang University of Chinese Medicine

The First Affiliated Hospital, College of Medicine, Zhejiang University

Department of Oncology, First Affiliated Hospital of Guangzhou University of Chinese Medicine

Cardiovascular Diseases Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰