Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

Yun-xiang Cao; Jian Liu; Yan Zhu

doi:10.1007/s11655-011-0873-1

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Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

Updated：2021-08-27

- Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis
- Chinese Journal of Integrative Medicine Vol. 17, Issue 10, Pages: 738-743(2011)
- Affiliations：
  
  Department of Rheumatology, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine,Hefei,China
- Author bio：
- Funds：
  
  Supported by the National Key Discipline of Traditional Chinese Medicine Project for Bi Diseases [Administration of Traditional Chinese Medicine, China (2009) No. 30], Program of Science and Technology Department of Anhui Province, China (No. 07010300204), and Traditional Chinese Medicine Research Project of Health Department of Anhui Province, China (No. 2009ZY05)
- DOI：10.1007/s11655-011-0873-1
  CLC：
- Published：2011，
  
  Published Online：26 March 2013，
Scan for full text
Cao, Yx., Liu, J. & Zhu, Y. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 738–743 (2011). https://doi.org/10.1007/s11655-011-0873-1

Yun-xiang Cao, Jian Liu, Yan Zhu. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis. [J]. Chinese Journal of Integrative Medicine 17(10):738-743(2011)
Cao, Yx., Liu, J. & Zhu, Y. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis., Chin. J. Integr. Med. 17, 738–743 (2011). https://doi.org/10.1007/s11655-011-0873-1 DOI：

Yun-xiang Cao, Jian Liu, Yan Zhu. Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis. [J]. Chinese Journal of Integrative Medicine 17(10):738-743(2011) DOI： 10.1007/s11655-011-0873-1.

摘要

To study the changes in cardiac function of rheumatoid arthritis (RA) patients and: to observe the effect of Xinfeng Capsule (新风胶囊

XFC) on them. Sixty-eight RA patients were: randomly assigned to two groups by a lottery: 38 patients in the treatment group treated orally with XFC

3 capsules

thrice a day

and 30 in the control group treated with Fengshi Gutong Capsule (风湿骨痛胶囊

FSGTC)

4 capsules

twice a day

30 days as one course of treatment

and two courses were given for both groups. A normal control (NC) group including 20 healthy subjects was set up. The clinical efficacy was compared between the two treated groups. The changes in cardiac function

including early diastolic peak flow velocity (E)

late diastolic peak flow velocity (A)

left ventricular fraction shortening (FS)

and E/A

as well as uric acid (UA)

erythrocyte sedimentation rate (ESR)

α-acid glycoprotein (α-AGP)

and hypersensitive C-reaction protein (hs-CRP)

were observed. The regulation T cell was determined with flow cytometry. (1) The total effective rate in the treatment group and the control group was 92.1%: (35/38) and 70.0% (21/30)

respectively. Significant difference was shown between them (P<0.05). (2) <Compared with those of the NC group

E peak

E/A ratio

and FS of RA patients were lower (P<0.01)

while <A peak was higher (P<0.01). Moreover

A peak of the treatment group after treatment was significantly lower <(P<0.05) and E/A ratio was significantly higher (<P<0.05) as compared with those of the control group. (3) The <improvement in the treatment group in reducing UA and hs-CRP was superior to those of the control group (P<0.05). In addition

the improvement in α-AGP

CD4 <CD4+CD25 CD25+ Treg

and CD4 CD4+CD25 CD25+CD127 CD127−Treg of the treatment group was obvious as compared with the control group

although the difference was not statistically significant. The descendent of cardiac function exists in RA patients. XFC could improve cardiac: function of RA patients

which is superior to FSGTC. Its mechanism may be related to its effect on raising CD4 CD4+CD25 CD25+Treg and CD4 CD4+CD25 CD25+CD127− Treg cells

decreasing UA

α-AGP

and hs-CRP levels

reducing immune inflammation

adjusting the overall balance of immune response

and thus improving the cardiac function of RA patients.

Abstract

To study the changes in cardiac function of rheumatoid arthritis (RA) patients and: to observe the effect of Xinfeng Capsule (新风胶囊

XFC) on them. Sixty-eight RA patients were: randomly assigned to two groups by a lottery: 38 patients in the treatment group treated orally with XFC

3 capsules

thrice a day

and 30 in the control group treated with Fengshi Gutong Capsule (风湿骨痛胶囊

FSGTC)

4 capsules

twice a day

30 days as one course of treatment

including early diastolic peak flow velocity (E)

late diastolic peak flow velocity (A)

left ventricular fraction shortening (FS)

and E/A

as well as uric acid (UA)

erythrocyte sedimentation rate (ESR)

α-acid glycoprotein (α-AGP)

and hypersensitive C-reaction protein (hs-CRP)

were observed. The regulation T cell was determined with flow cytometry. (1) The total effective rate in the treatment group and the control group was 92.1%: (35/38) and 70.0% (21/30)

respectively. Significant difference was shown between them (P<0.05). (2) <Compared with those of the NC group

E peak

E/A ratio

and FS of RA patients were lower (P<0.01)

while <A peak was higher (P<0.01). Moreover

the improvement in α-AGP

CD4 <CD4+CD25 CD25+ Treg

and CD4 CD4+CD25 CD25+CD127 CD127−Treg of the treatment group was obvious as compared with the control group

although the difference was not statistically significant. The descendent of cardiac function exists in RA patients. XFC could improve cardiac: function of RA patients

which is superior to FSGTC. Its mechanism may be related to its effect on raising CD4 CD4+CD25 CD25+Treg and CD4 CD4+CD25 CD25+CD127− Treg cells

decreasing UA

α-AGP

and hs-CRP levels

reducing immune inflammation

adjusting the overall balance of immune response

and thus improving the cardiac function of RA patients.

关键词

rheumatoid arthritiscardiac functionregulation T cellinflammatory factorXinfeng Capsule

Keywords

rheumatoid arthritiscardiac functionregulation T cellinflammatory factorXinfeng Capsule

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Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine

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