An innovative herbal product for the prevention of osteoporosis

Ping-chung Leung; King-fai Cheng; Yat-heung Chan

doi:10.1007/s11655-011-0876-y

Your Location：

Home >

Browse articles >

An innovative herbal product for the prevention of osteoporosis

Updated：2021-08-27

- An innovative herbal product for the prevention of osteoporosis
- Chinese Journal of Integrative Medicine Vol. 17, Issue 10, Pages: 744-749(2011)
- Affiliations：
  
  1. Institute of Chinese Medicine, The Chinese University of Hong Kong,Hong Kong,China
  2. Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong,Hong Kong,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0876-y
  CLC：
- Published：2011，
  
  Published Online：26 March 2013，
Scan for full text
Leung, Pc., Cheng, Kf. & Chan, Yh. An innovative herbal product for the prevention of osteoporosis., Chin. J. Integr. Med. 17, 744–749 (2011). https://doi.org/10.1007/s11655-011-0876-y

Ping-chung Leung, King-fai Cheng, Yat-heung Chan. An innovative herbal product for the prevention of osteoporosis. [J]. Chinese Journal of Integrative Medicine 17(10):744-749(2011)
Leung, Pc., Cheng, Kf. & Chan, Yh. An innovative herbal product for the prevention of osteoporosis., Chin. J. Integr. Med. 17, 744–749 (2011). https://doi.org/10.1007/s11655-011-0876-y DOI：

Ping-chung Leung, King-fai Cheng, Yat-heung Chan. An innovative herbal product for the prevention of osteoporosis. [J]. Chinese Journal of Integrative Medicine 17(10):744-749(2011) DOI： 10.1007/s11655-011-0876-y.

摘要

To prevent the deterioration of osteopenia

a triple herb product Bo-gu Ling (补骨灵

ELP) was created for a clinical trial on post-menopausal women suffering from osteopenia. The design of the clinical trial was of randomized

double-blind

placebo-controlled nature. A total of 150 women aged 40–60 years

who were after menopause for at least 1 year and their lumbar spine bone mineral density (BMD) must be lower than 0.891 g/cm2

were recruited and randomly divided into the ELP group treated with ELP and the placebo group

with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline

6 and 12 months after treatment. Secondary endpoints included peripheral quantitative computed tomography (pQCT) measurements of distal tibia and the changes in the quality of life (QOL). The spine BMD of the ELP group was increased by 0.69% in the subjects who were more than 10 years after menopause. In contrast

the placebo group of the same stratum decreased by 0.61% (P=0.067). In the subjects with more than 10 years duration of menopause

the hip BMD increased by 0.21% in the ELP group

compared with a decrease of 0.52% in the placebo group (P=0.159). The tibia strengthstrain index was increased by 1.94% in the ELP group compared with 0.33% in the placebo group (P=0.047). Physical function of SF-36 QOL questionnaire was remarkably improved compared with the baseline

but did not show dominance over the placebo group. ELP showed potential benefifit in improving BMD on the women who experienced over 10 years of menopause.

Abstract

To prevent the deterioration of osteopenia

a triple herb product Bo-gu Ling (补骨灵

ELP) was created for a clinical trial on post-menopausal women suffering from osteopenia. The design of the clinical trial was of randomized

double-blind

placebo-controlled nature. A total of 150 women aged 40–60 years

who were after menopause for at least 1 year and their lumbar spine bone mineral density (BMD) must be lower than 0.891 g/cm2

were recruited and randomly divided into the ELP group treated with ELP and the placebo group

with 75 in each group. The primary endpoint was the BMD of the lumbar spine that was assessed at baseline

the placebo group of the same stratum decreased by 0.61% (P=0.067). In the subjects with more than 10 years duration of menopause

the hip BMD increased by 0.21% in the ELP group

but did not show dominance over the placebo group. ELP showed potential benefifit in improving BMD on the women who experienced over 10 years of menopause.

关键词

prevention of osteoporosisHerbal ProductBone Mineral Density

Keywords

prevention of osteoporosisHerbal ProductBone Mineral Density

references

Riggs BL, Melton LJ. The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 1995;17(5 Suppl):S505–S511.

Dambacher MA, Schmitt S, Schacht E, Ito M, Neff M, Muller R, et al. Bone structures in vitro and in vivo in animals and men: a view into the future. J Miner Stoffwechs 2004;2:22–28.

National Institutes of Health (NIH), USA (2000). NIH consensus statement on osteoporosis prevention, diagnosis and therapy. 27–29 March 2000. Accessed at http://consensus.nih.gov.

Consensus Development Conference. Diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993;94:646–650.

Neviaser AS, Lane JM, Lenart BA, Edobor-Osula F, Lorich DG. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma 2008;22:346–350.

Leung F, Lau TW, To M, Luk KDK, Kung AWC. Atypical femoral diaphyseal and subtrochanteric fractures and their association with bisphosphonates. BMJ Case Rep 2009;368:316–320.

Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CYC. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 2005;90:1294–1301.

Yang F, Xu MR, Yang MF, Lam CH, Lau MT, Yuan ZH. Patterns of the use of traditional Chinese medicines in the treatment of osteoporosis. Chin J Clin Rehabil (Chin) 2005;9:203–205.

National Committee of Pharmacopoeia. Pharmacopoeia of the People’s Republic of China (2005). Part I. Kidney tonics Chinese pharmacopoeia. Beijing: Chemical Industriy Press; 2005:444–445.

Zhang Y, Lai WP, Leung PC, Wu CF, Yao XS, Wong MS. Effects of Fructus Ligustri Lucidi extract on bone turnover and calcium balance in ovariectomized rats. Biol Pharm Bull 2006;29:291–296.

Sun Y, Lee SMY, Wong YM, Lau CP, Shaw PC, Qin L, et al. Dosing effects of an antiosteoporosis herbal formula—a preclinical investigation using a rat model. Phytotherapy Res 2008;22:267–73.

Xie YM, Zhu YY, Wu TX. Effects and safety of traditional Chinese medicine for treating postmenopausal osteoporosis: a systematic review. Chin J Evid Based Med (Chin) 2005;5:29–41,74.

Leung PC. Intelligent use of traditional Chinese medicine. In: a comprehensive guide to Chinese medicine. Chapter 1. Singapore: World Scientifi c Publisher; 2003:1–18.

Chen ST, Dou JH, Temple R, Agarwal R, Wu KM, Walker S. New therapies from old medicine. Nat Biotechnol 2008;26:1077–1083.

Wong SY, Kwok T, Woo J, Lynn H, Griffith JF, Leung PC. Bone mineral density and the risk of peripheral arterial disease in men and women: results from Mr. and Ms. Os, Hong Kong. Osteoporos Int 2005;16:1933–1938.

Yu S, Chen K, Li S, Zhang K. In vitro and in vivo studies of the effect of a Chinese herb medicine on osteoclastic bone resorption. Chin J Dent Res (Chin) 1999;2:7–11.

Kanis JA, Melton LJ, Christiansen C, Johnston CC, Khaltaev N. The diagnosis of osteoporosis. J Bone Miner Res 1994;9:1137–1141.

Kerr D, Morton A, Dick I, Prince R. Exercise effects on bone mass in postmenopausal women are site-specific and loaddependent. J Bone Mineral Res 1996;11:218–225.

Chau FT, Chan HY, Cheung CY, Cheng JX, Liang YZ, Kvalhe OM. Recipe for uncovering the bioactive components in herbal medicine. Anal Chem 2009;81:7217–7225.

Chau FT, Liang YZ, Gao JB, Zhao S. Chemometrics: from basic to wavelet transform. Vol. 164. Chemical Analysis Series. Hoboken: John Wiley and Sons, Inc; 2004:232–249.

Mok DK, Chan FT. Chemical information of Chinese medicine: a challenge to chemist. Chemom Intell Lab Syst 2006;82:210–217.

FULL TEXT LINK

More>

Views

730

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Clinical practice guideline of traditional medicine for primary osteoporosis

Effect of Gengnianchun Recipe on bone mineral density, bone biomechanical parameters and serum lipid level in ovariectomized rats

The more efficacious acupoints of Zusanli and Sanyinjiao than that of non-acupoints on bone mass in osteopenic Ovariectomized rats

Research progress of liver diseases

Academic minutes for the 2nd World Integrative Medicine Congress

Related Author

No data

Related Institution

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences

Wangjing Hospital of China Academy of Chinese Medical Science

Fujian University of Chinese Medicine

Orthopedic Hospital of Guangzhou University of Traditional Chinese Medicine

China Traditional Chinese Medicine Publishing House

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰