FOLLOWUS
The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage
- Chinese Journal of Integrative Medicine Vol. 18, Issue 4, Pages: 299-303(2012)
- Affiliations：
1. Department of Ophthalmology, the First Affiliated Hospital of the General Hospital of PLA,Beijing,China
2. Department of Ophthalmology, the General Hospital of People’s Liberation Army,Beijing,China
- Author bio：
- Funds：
DOI：10.1007/s11655-011-0901-1
CLC：Published：2012，
Published Online：30 March 2012，
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Yin, L., Pi, Yl. & Zhang, Mn. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage., Chin. J. Integr. Med. 18, 299–303 (2012). https://doi.org/10.1007/s11655-011-0901-1
Lan Yin, Yu-li Pi, Mao-nian Zhang. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage. [J]. Chinese Journal of Integrative Medicine 18(4):299-303(2012)
Yin, L., Pi, Yl. & Zhang, Mn. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage., Chin. J. Integr. Med. 18, 299–303 (2012). https://doi.org/10.1007/s11655-011-0901-1 DOI：
Lan Yin, Yu-li Pi, Mao-nian Zhang. The effect of Vaccinium uliginosum on rabbit retinal structure and light-induced function damage. [J]. Chinese Journal of Integrative Medicine 18(4):299-303(2012) DOI： 10.1007/s11655-011-0901-1.
摘要
To study the effect of Vaccinium uliginosum L.
(VU) on the electroretinogram (ERG) and retinal pathological changes in rabbits after light-induced damage. Twenty-eight Chinchilla rabbits were randomly divided into four groups: administration beforehand (A)
administration after injury (B)
light injury without administration (C)
and blank (D) groups. After a 4-week administration of VU homogenate at 4.8 g/(kg·d) once a day in group A
ERG in groups A
B and C were recorded according to the standards set by the International Society for Clinical Electrophysiology of Vision (ISCEV). Except for group D
the groups were then exposed to strong light. Just after that
group A stopped receiving VU treatment and group B started to receive it. Then ERGs in all groups were recorded after 1 day
1 week
and 2 weeks. Throughout the whole process groups which were not fed with VU were fed with normal saline. Finally
the tissues and structures of all the groups were observed and the thickness of the outer nuclear layers (ONL) was measured. (1) After 4-week feeding with VU
the latency time of ERG in group A became shorter than those in the other groups and the amplitude increased. After being exposed to strong light
the latency time lengthened and amplitude decreased in all the injury groups
but comparing at each time point
the measured values in group A were better than those in group C. With the accumulation of VU
the ERG in group B improved
and finally
all of the detected values became better than those in group C. (2) Retinae in group D were normal in histology and the layers were in order but those in group C became disarranged. The injuries in groups A and B were minor compared with those in group C. The thickness of the ONL in group C was significantly thinner than in the other groups (P=0.000)
and that in groups A and B was thicker than that in group C
although thinner than in group D. That in group A was thicker than in group B. VU can relieve the injury to rabbit retinae exposed to normal day and night rhythm
alleviate the harm caused by light when used beforehand
and repair the light damage to the retina.
Abstract
To study the effect of Vaccinium uliginosum L.
(VU) on the electroretinogram (ERG) and retinal pathological changes in rabbits after light-induced damage. Twenty-eight Chinchilla rabbits were randomly divided into four groups: administration beforehand (A)
administration after injury (B)
light injury without administration (C)
and blank (D) groups. After a 4-week administration of VU homogenate at 4.8 g/(kg·d) once a day in group A
ERG in groups A
B and C were recorded according to the standards set by the International Society for Clinical Electrophysiology of Vision (ISCEV). Except for group D
the groups were then exposed to strong light. Just after that
group A stopped receiving VU treatment and group B started to receive it. Then ERGs in all groups were recorded after 1 day
1 week
and 2 weeks. Throughout the whole process groups which were not fed with VU were fed with normal saline. Finally
the tissues and structures of all the groups were observed and the thickness of the outer nuclear layers (ONL) was measured. (1) After 4-week feeding with VU
the latency time of ERG in group A became shorter than those in the other groups and the amplitude increased. After being exposed to strong light
the latency time lengthened and amplitude decreased in all the injury groups
but comparing at each time point
the measured values in group A were better than those in group C. With the accumulation of VU
the ERG in group B improved
and finally
all of the detected values became better than those in group C. (2) Retinae in group D were normal in histology and the layers were in order but those in group C became disarranged. The injuries in groups A and B were minor compared with those in group C. The thickness of the ONL in group C was significantly thinner than in the other groups (P=0.000)
and that in groups A and B was thicker than that in group C
although thinner than in group D. That in group A was thicker than in group B. VU can relieve the injury to rabbit retinae exposed to normal day and night rhythm
alleviate the harm caused by light when used beforehand
and repair the light damage to the retina.
关键词
Vaccinium uliginosum L.light-induced damageelectroretinogramhistology
Keywords
Vaccinium uliginosum L.light-induced damageelectroretinogramhistology
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