Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity

Sunmin Park; Jung Bok Lee; James W. Daily

doi:10.1007/s11655-011-0936-3

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Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity

Updated：2021-08-27

- Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity
- Chinese Journal of Integrative Medicine Vol. 17, Issue 12, Pages: 925-932(2011)
- Affiliations：
  
  1. Department of Food and Nutrition, Obesity/Diabetes Research Institutes, Hoseo University, Asan, South Korea
  2. Daily Manufacturing Inc., Rockwell,NC,USA
- Author bio：
- Funds：
  
  Supported by the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (HMP-08-A-0-80958)
- DOI：10.1007/s11655-011-0936-3
  CLC：
- Published：2011，
  
  Published Online：3 December 2011，
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Park, S., Lee, J.B. & Daily, J.W. Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity., Chin. J. Integr. Med. 17, 925–932 (2011). https://doi.org/10.1007/s11655-011-0936-3

Sunmin Park, Jung Bok Lee, James W. Daily. Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity. [J]. Chinese Journal of Integrative Medicine 17(12):925-932(2011)
Park, S., Lee, J.B. & Daily, J.W. Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity., Chin. J. Integr. Med. 17, 925–932 (2011). https://doi.org/10.1007/s11655-011-0936-3 DOI：

Sunmin Park, Jung Bok Lee, James W. Daily. Anti-Obesity effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤) in female rats with diet-induced obesity. [J]. Chinese Journal of Integrative Medicine 17(12):925-932(2011) DOI： 10.1007/s11655-011-0936-3.

摘要

To investigate the effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤

CCEET)

modififi ed CCEET (MCCEET)

and Semen Coicis (SC

a major component of CCEET) on energy and glucose homeostasis. The possible mechanism of action of CCEET was also determined. A total of 100 Sprague Dawley female rats were randomly assigned to 5 groups

with 20 in each group. Rats in 4 groups were fed with a high fat diet supplementation (2 g/kg body weight)

and water extracts of CCEET

MCCEET

and cellulose (negative control)

respectively. The last group was fed with a low-fat diet as a positive control. Results: CCEET and MCCEET decreased body weight and body fat (mesenteric and retroperitoneal fat) more than SC. This decrease was due to decreased energy intake and increased energy expenditure and fat oxidation. The improvement in energy homeostasis was associated with the enhancement of the hypothalamic leptin signalling pathway involving potentiating the phosphorylation of the signal transducer and activator of transcription-3

as well as attenuating the phosphorylation of 5’ adenosine monophosphate-activated protein kinase (AMPK). Both CCEET and MCCEET improved glucose tolerance without changing serum insulin levels during an oral glucose tolerance test but MCCEET had a better effect than CCEET. Both CCEET and MCCEET safely exerted anti-obesity effects by enhancing energy balance in female rats with diet-induced obesity; MCCEET showed a better effect on glucose homeostasis.

Abstract

To investigate the effects of Chang-Chul-Eui-Ee-In-Tang (苍术薏苡仁汤

CCEET)

modififi ed CCEET (MCCEET)

and Semen Coicis (SC

with 20 in each group. Rats in 4 groups were fed with a high fat diet supplementation (2 g/kg body weight)

and water extracts of CCEET

MCCEET

and cellulose (negative control)

关键词

Chang-Chul-Eui-Ee-In-TangSemen Coicisleptinsignal transducer and activator of transcription-35′ adenosine monophosphate-activated protein kinasehypothalamus

Keywords

Chang-Chul-Eui-Ee-In-TangSemen Coicisleptinsignal transducer and activator of transcription-35′ adenosine monophosphate-activated protein kinasehypothalamus

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Department of Physiology, Institute of Acu-moxibustion, China Academy of Chinese Medical Sciences

Fujian Institute of Integrative Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine

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