Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

Sina Kim; Byung-Cheul Shin; Myeong Soo Lee; Hyangsook Lee; Edzard Ernst

doi:10.1007/s11655-011-0937-2

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Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials

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- Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials
- Chinese Journal of Integrative Medicine Vol. 17, Issue 12, Pages: 937-944(2011)
- Affiliations：
  
  1. School of Korean Medicine, Pusan National University, Yangsan, South Korea
  2. Brain Disease Research Centre, Korea Institute of Oriental Medicine, Daejeon, South Korea
  3. Complementary Medicine, Peninsula Medical School, University of Exeter (EX2-4NT),Exeter,UK
  4. Acupuncture and Meridian Science Research Centre, College of Korean Medicine, Kyung Hee University, Seoul, South Korea
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0937-2
  CLC：
- Published：2011，
  
  Published Online：3 December 2011，
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Kim, S., Shin, BC., Lee, M.S. et al. Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 17, 937–944 (2011). https://doi.org/10.1007/s11655-011-0937-2

Sina Kim, Byung-Cheul Shin, Myeong Soo Lee, et al. Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 17(12):937-944(2011)
Kim, S., Shin, BC., Lee, M.S. et al. Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials., Chin. J. Integr. Med. 17, 937–944 (2011). https://doi.org/10.1007/s11655-011-0937-2 DOI：

Sina Kim, Byung-Cheul Shin, Myeong Soo Lee, et al. Red ginseng for type 2 diabetes mellitus: A systematic review of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 17(12):937-944(2011) DOI： 10.1007/s11655-011-0937-2.

摘要

Red ginseng (RG

Panax ginseng C.A. Meyer) is one of the widely used herbs for treating type 2 diabetes mellitus (DM). However

no systematic review of the effectiveness of RG for type 2 DM is available. This systematic review aimed to evaluate the current evidence for the effectiveness of RG in patients with type 2 DM. Electronic searches of 14 electronic databases were conducted without language restrictions. All randomized clinical trials (RCTs) with RG as a treatment for type 2 DM were considered for inclusion. Their methodological quality was assessed using the Cochrane criteria. Four RCTs met our inclusion criteria. Their methodological quality was variable. Three of the RCTs compared the effectiveness of RG with placebo. The meta-analysis of these data failed to favor RG over placebo for fasting plasma glucose (FPG) [n =76

weighted mean difference (WMD): −0.43 mmol/L; 95% confidence interval (CI): −1.16 to 0.30

=0.25] and fasting plasma insulin (FPI) (n =76

WMD: −8.43 pmol/L; 95% CI: −19.54 to 2.68

P =0.14) for 12 weeks of treatment. One RCT compared the effects of RG with no treatment. The results did not suggest favorable effects of RG on FPG

hemoglobin A1c (HbA1c) or 2-h blood glucose after a meal (PP2h). The evidence for the effectiveness of RG in controlling glucose in type 2 DM is not convincing. Few included studies with various treatment regimens prohibit definitive conclusions. More rigorous studies are needed to clarify the effects of RG on this condition.

Abstract

Red ginseng (RG

Panax ginseng C.A. Meyer) is one of the widely used herbs for treating type 2 diabetes mellitus (DM). However

weighted mean difference (WMD): −0.43 mmol/L; 95% confidence interval (CI): −1.16 to 0.30

=0.25] and fasting plasma insulin (FPI) (n =76

WMD: −8.43 pmol/L; 95% CI: −19.54 to 2.68

P =0.14) for 12 weeks of treatment. One RCT compared the effects of RG with no treatment. The results did not suggest favorable effects of RG on FPG

关键词

red GinsengPanax Ginsengtype 2 diabetes mellitussystematic reviewmeta-analysis

Keywords

red GinsengPanax Ginsengtype 2 diabetes mellitussystematic reviewmeta-analysis

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Department of Cardiovascular and Neurologic Diseases, College of Oriental Medicine, Graduate School, Kyung Hee University, Seoul, South Korea

Acupuncture, Moxibustion and Meridian Research Center, Korea Institute of Oriental Medicine, Daejeon, South Korea

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