The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia

Hui Li; Zhen-yu Yang; Yan Li

doi:10.1007/s11655-011-0951-4

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The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia

Updated：2021-08-27

- The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia
- Chinese Journal of Integrative Medicine Vol. 19, Issue 3, Pages: 223-227(2013)
- Affiliations：
  
  1. Department of Gastroenterology, Shengjing Hospital of China Medical University,Shenyang,China
  2. Intensive Care Unit, Shengjing Hospital of China Medical University,Shenyang,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-011-0951-4
  CLC：
- Published：2013，
  
  Published Online：27 February 2012，
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Li, H., Yang, Zy. & Li, Y. The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia., Chin. J. Integr. Med. 19, 223–227 (2013). https://doi.org/10.1007/s11655-011-0951-4

Hui Li, Zhen-yu Yang, Yan Li. The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia. [J]. Chinese Journal of Integrative Medicine 19(3):223-227(2013)
Li, H., Yang, Zy. & Li, Y. The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia., Chin. J. Integr. Med. 19, 223–227 (2013). https://doi.org/10.1007/s11655-011-0951-4 DOI：

Hui Li, Zhen-yu Yang, Yan Li. The therapeutic effect of Xiaopi-I(消痞I号) on functional dyspepsia. [J]. Chinese Journal of Integrative Medicine 19(3):223-227(2013) DOI： 10.1007/s11655-011-0951-4.

摘要

To observe the therapeutic efficacy of Xiaopi-I(消痞I号) on functional dyspepsia and its effects on gastric emptying. A total of 134 patients with functional dyspepsia were randomly assigned to 2 groups. The patients in the Xiaopi-I group (66 cases) and the Domperidone group (68 cases) were given Xiaopi-I granules and Domperidone 10 mg

3 times a day

respectively. Another 20 healthy volunteers were chosen as the negative control group. The severity scores of the symptoms

as well as the gastric emptying

were detected before and after 4-week treatment by barium strip-trial meal. During therapy

6 cases from the Xiaopi-I group and 8 cases from the Domperidone group were lost to follow

and 120 cases finally finished the study. Statistical differences were observed from both groups in terms of the symptoms of postprandial fullness early satiety

epigastric pain

and epigastric burning after 4-week treatment (P<0.01). The symptomatic severity scores of the Xiaopi-I group before and after the treatment were 7.48±1.64 and 2.16±1.26

respectively (P<0.01). Gastric emptying rates were also improved in the patients with delayed gastric emptying

and the effective rates were 91.3% and 75.8% in the Xiaopi-I and Domperidone groups

respectively. No obvious adverse effects were found from both groups. Xiaopi-I was an effective and safe agent in the treatment of functional dyspepsia and was worth of further development in clinical.

Abstract

3 times a day

respectively. Another 20 healthy volunteers were chosen as the negative control group. The severity scores of the symptoms

as well as the gastric emptying

were detected before and after 4-week treatment by barium strip-trial meal. During therapy

6 cases from the Xiaopi-I group and 8 cases from the Domperidone group were lost to follow

and 120 cases finally finished the study. Statistical differences were observed from both groups in terms of the symptoms of postprandial fullness early satiety

epigastric pain

and epigastric burning after 4-week treatment (P<0.01). The symptomatic severity scores of the Xiaopi-I group before and after the treatment were 7.48±1.64 and 2.16±1.26

respectively (P<0.01). Gastric emptying rates were also improved in the patients with delayed gastric emptying

and the effective rates were 91.3% and 75.8% in the Xiaopi-I and Domperidone groups

关键词

functional dyspepsiaXiaopi-Ibarium strip-trial mealChinese Medicine

Keywords

functional dyspepsiaXiaopi-Ibarium strip-trial mealChinese Medicine

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Related Institution

Department of Medical Statistics, School of Public Health, Sun Yat-sen University

Gastroenterology Department, the First Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine

Postgraduate Department, Guangzhou University of Traditional Chinese Medicine

Georg-August-Universität Göttingen, Göttingen

The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics’ Ministry of Public Health

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