Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer

Guo-yong Shan; Song Zhang; Guo-wen Li; Yong-shun Chen; Xing-an Liu; Jian-kun Wang

doi:10.1007/s11655-011-0953-2

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Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer

Updated：2021-08-27

- Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer
- Chinese Journal of Integrative Medicine Vol. 17, Issue 12, Pages: 933-936(2011)
- Affiliations：
  
  1. Department of Radiation Oncology, Zhengzhou People’s Hospital,Zhengzhou,China
  2. Department of Radiation Oncology, Affiliated Hospital of Zhengzhou University,Zhengzhou,China
- Author bio：
- Funds：
  
  Supported by the Science and Technology Plan, Development and Support Projects of Zhengzhou City (No. 0910SGYS33377-1)
- DOI：10.1007/s11655-011-0953-2
  CLC：
- Published：2011，
  
  Published Online：3 December 2011，
Scan for full text
Shan, Gy., Zhang, S., Li, Gw. et al. Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer., Chin. J. Integr. Med. 17, 933–936 (2011). https://doi.org/10.1007/s11655-011-0953-2

Guo-yong Shan, Song Zhang, Guo-wen Li, et al. Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer. [J]. Chinese Journal of Integrative Medicine 17(12):933-936(2011)
Shan, Gy., Zhang, S., Li, Gw. et al. Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer., Chin. J. Integr. Med. 17, 933–936 (2011). https://doi.org/10.1007/s11655-011-0953-2 DOI：

Guo-yong Shan, Song Zhang, Guo-wen Li, et al. Clinical evaluation of oral Fructus Bruceae oil combined with radiotherapy for the treatment of esophageal cancer. [J]. Chinese Journal of Integrative Medicine 17(12):933-936(2011) DOI： 10.1007/s11655-011-0953-2.

摘要

To evaluate the therapeutic efficacy and side effects of oral Fructus bruceae oil combined with radiotherapy in the treatment of esophageal cancer. A total of 80 patients with esophageal cancer were equally and randomly divided into two groups. The patients in Group A were treated with radiotherapy (60–65 Gy

6–7 weeks) and oral Fructus bruceae oil (20 mL

3 times per day for 12 weeks)

while the patients in Group B were treated with radiotherapy alone. The short-term effect was evaluated by Response Evaluation Criteria in Solid Tumors (RECIST) and quality of life (QOL) was evaluated by the Karnofsky scoring (KFS). The outcome measures included complete remission (CR) rate

partial remission (PR) rate

effective rate as CR+PR

patients’ QOL and adverse effects. After 12-week treatment

the CR and CR+PR were significantly higher in Group A than those in Group B (P <0.05). There was an improvement in esophageal obstruction of 87.5% and 60.0%

respectively

and in KFS of 84.6% and 43.9%

respectively

in Groups A and B. Oral medication with oral Fructus bruceae oil could effectively improve the efficacy of radiotherapy in esophageal cancer

including a reduction in esophageal obstruction

and also reduce the side effects of radiotherapy; thus it would be very promising for clinical application.

Abstract

6–7 weeks) and oral Fructus bruceae oil (20 mL

3 times per day for 12 weeks)

partial remission (PR) rate

effective rate as CR+PR

patients’ QOL and adverse effects. After 12-week treatment

the CR and CR+PR were significantly higher in Group A than those in Group B (P <0.05). There was an improvement in esophageal obstruction of 87.5% and 60.0%

respectively

and in KFS of 84.6% and 43.9%

respectively

in Groups A and B. Oral medication with oral Fructus bruceae oil could effectively improve the efficacy of radiotherapy in esophageal cancer

including a reduction in esophageal obstruction

and also reduce the side effects of radiotherapy; thus it would be very promising for clinical application.

关键词

Fructus bruceaeesophageal cancerradiotherapyChinese Medicine

Keywords

Fructus bruceaeesophageal cancerradiotherapyChinese Medicine

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