Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention

Hong-ying Liu; Wei Wang; Da-zhuo Shi; Jun-bo Ge; Lei Zhang; Juan Peng; Cheng-long Wang; Pei-li Wang

doi:10.1007/s11655-012-0966-5

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Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention

Updated：2021-08-27

- Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention
- Chinese Journal of Integrative Medicine Vol. 18, Issue 6, Pages: 423-430(2012)
- Affiliations：
  
  1. Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
  2. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University,Shanghai,China
- Author bio：
- Funds：
  
  Supported by the Key Projects in the National Science and Technology Pillar Program during the Eleventh Five-year Plan Period (No. 2006BA104A01)
- DOI：10.1007/s11655-012-0966-5
  CLC：
- Published：2012，
  
  Published Online：29 February 2012，
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Liu, Hy., Wang, W., Shi, Dz. et al. Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention., Chin. J. Integr. Med. 18, 423–430 (2012). https://doi.org/10.1007/s11655-012-0966-5

Hong-ying Liu, Wei Wang, Da-zhuo Shi, et al. Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention. [J]. Chinese Journal of Integrative Medicine 18(6):423-430(2012)
Liu, Hy., Wang, W., Shi, Dz. et al. Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention., Chin. J. Integr. Med. 18, 423–430 (2012). https://doi.org/10.1007/s11655-012-0966-5 DOI：

Hong-ying Liu, Wei Wang, Da-zhuo Shi, et al. Protective effect of Chinese herbs for supplementing qi, nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome after percutaneous coronary intervention. [J]. Chinese Journal of Integrative Medicine 18(6):423-430(2012) DOI： 10.1007/s11655-012-0966-5.

摘要

To investigate the effects of Chinese herbs for supplementing qi

nourishing yin and activating blood circulation on heart function of patients with acute coronary syndrome (ACS) after successful percutaneous coronary intervention (PCI). One hundred patients with ACS after successful PCI were randomly assigned to a Western medicine (WM) treatment group (WMG) and a combined treatment group (CMG) treated by Chinese herbs for supplementing qi

nourishing yin and activating blood circulation

besides Western medicine treatment

with 50 cases in each group. Both treatment courses were 6 months. The followup was scheduled at baseline

6 months and 1 year after PCI

and New York Heart Association (NYHA) functional class

Chinese medicine (CM) symptom scores

blood stasis syndrome scores

and major adverse cardiovascular events (MACE) were observed

serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and hyper-sensitivity C-reactive protein (Hs-CRP) were measured

an echocardiogram was conducted to examine left ventricular ejection fraction (LVEF)

left ventricular end-diastolic volume (LVEDV)

left ventricular end-systolic volume (LVESV)

inter-ventricular septal thickness (IVST)

left ventricular posterior wall thickness (LVPWT)

and ventricular wall motion index (VWMI). Compared with the baseline

LVEF significantly increased (P<0.01)

and CM symptom scores

blood stasis syndrome scores

VWMI

LVEDV

LVESV

NT-proBNP

and Hs-CRP all decreased (P<0.01) in both groups at 6 months and at 1 year after PCI. There were no significant differences in all the above parameters at 1 year vs those at 6 months after PCI (P>0.05). VWMI

LVEDV

LVESV

NT-proBNP

Hs-CRP

LVEF

and CM symptom and blood stasis syndrome scores were all improved obviously in CMG than those in WMG (P<0.05 or P<0.01) at 6 months and at 1 year after PCI. There were no significant differences in NYHA functional class between CMG and WMG at different follow-up timepoints; it was notable that value was 0.054 when comparing the cases of NYHA functional class between the two groups at 1-year follow-up. During the 1-year follow-up

3 MACE and 11 MACE occurred in CMG and WMG

respectively; the MACE rate in CMG was lower than that in WMG (6% vs 22%

P<0.05). Chinese herbs for supplementing qi

nourishing yin and activating blood circulation could improve heart function

reduce the CM symptom scores and blood stasis syndrome scores

and decrease the incidence of MACE in patients with ACS after successful PCI.

Abstract

To investigate the effects of Chinese herbs for supplementing qi

nourishing yin and activating blood circulation

besides Western medicine treatment

with 50 cases in each group. Both treatment courses were 6 months. The followup was scheduled at baseline

6 months and 1 year after PCI

and New York Heart Association (NYHA) functional class

Chinese medicine (CM) symptom scores

blood stasis syndrome scores

and major adverse cardiovascular events (MACE) were observed

serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and hyper-sensitivity C-reactive protein (Hs-CRP) were measured

an echocardiogram was conducted to examine left ventricular ejection fraction (LVEF)

left ventricular end-diastolic volume (LVEDV)

left ventricular end-systolic volume (LVESV)

inter-ventricular septal thickness (IVST)

left ventricular posterior wall thickness (LVPWT)

and ventricular wall motion index (VWMI). Compared with the baseline

LVEF significantly increased (P<0.01)

and CM symptom scores

blood stasis syndrome scores

VWMI

LVEDV

LVESV

NT-proBNP

LVEDV

LVESV

NT-proBNP

Hs-CRP

LVEF

3 MACE and 11 MACE occurred in CMG and WMG

respectively; the MACE rate in CMG was lower than that in WMG (6% vs 22%

P<0.05). Chinese herbs for supplementing qi

nourishing yin and activating blood circulation could improve heart function

reduce the CM symptom scores and blood stasis syndrome scores

and decrease the incidence of MACE in patients with ACS after successful PCI.

关键词

supplementing qinourishing yin and activating blood circulationPercutaneous Coronary Interventionacute coronary syndrome

Keywords

supplementing qinourishing yin and activating blood circulationPercutaneous Coronary Interventionacute coronary syndrome

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Department of Cardiology, Peking University First Hospital

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University

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Institute of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Zhejiang University of Chinese Medicine

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