Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

Nuo Li; Yue-qing Li; Hong-yan Li; Wei Guo; Yan-ping Bai

doi:10.1007/s11655-012-1004-3

Your Location：

Home >

Browse articles >

Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review

Updated：2021-08-27

- Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review
- Chinese Journal of Integrative Medicine Vol. 18, Issue 3, Pages: 222-229(2012)
- Affiliations：
  
  1. The First Hospital of Beijing University of Chinese Medicine,Beijing,China
  2. Department of Dermatology, China-Japan Friendship Hospital, Beijng,China
  3. Janssen Pharmaceutical Ltd., Beijing,Xi’an,China
- Author bio：
- Funds：
  
  Supported by the Eleventh Five-Year Program, Ministry of Science and Technology of China (No. 2008BAI53B044)
- DOI：10.1007/s11655-012-1004-3
  CLC：
- Published：2012，
  
  Published Online：2 April 2012，
Scan for full text
Li, N., Li, Yq., Li, Hy. et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review., Chin. J. Integr. Med. 18, 222–229 (2012). https://doi.org/10.1007/s11655-012-1004-3

Nuo Li, Yue-qing Li, Hong-yan Li, et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review. [J]. Chinese Journal of Integrative Medicine 18(3):222-229(2012)
Li, N., Li, Yq., Li, Hy. et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review., Chin. J. Integr. Med. 18, 222–229 (2012). https://doi.org/10.1007/s11655-012-1004-3 DOI：

Nuo Li, Yue-qing Li, Hong-yan Li, et al. Efficacy of externally applied Chinese herbal drugs in treating psoriasis: A systematic review. [J]. Chinese Journal of Integrative Medicine 18(3):222-229(2012) DOI： 10.1007/s11655-012-1004-3.

摘要

To assess the efficacy and safety of external application of Chinese herbal drugs (ex-CHD) in the treatment of psoriasis. Literature regarding randomized clinical trials (RCTs) of psoriasis treatments with ex-CHD

either alone or combined with Western medicine (WM) or physiotherapy

controlled by untreated

placebo or WM treatment were found in electronic databases

including PubMed/MEDLINE

EMBASE

Cochrane Library

Cochrane Central Register of Controlled Trials

China Biology Medicine Disc (CBM)

Chinese National Knowledge Infrastructure (CNKI)

Wanfang database and VIP database from their inception through July 2011. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. A total of 10 randomized trials (involving 1

435 patients) were included. Because both test and control drugs used in the RCTs were different from each other

the effects can only be described singly and calculated. Regarding the total effective rate for the treatment of psoriasis

ex-CHD in combination with ultraviolet radiation b (UVB) or narrow band ultraviolet radiation b (NB-UVB)

which was reported in 6 trials

was superior to UVB alone. One study reported that ex-CHD and externally applied WM had equivalent effects. In another study

ex-CHD showed better results than placebo. However

another two comparisons of ex-CHD and WM (all in combining with oral WM) showed uncertain outcomes. Nine trials reported adverse reactions. Of these

7 RCTs included statistical analysis. The results showed that the side-effects that occurred in ex-CHD combined with UVB were less severe than those caused by UVB alone

but the incidence was roughly the same as WM. The evidence supporting the efficacy of ex-CHD with respect to treating psoriasis is quite limited and must be strengthened by high-quality studies.

Abstract

either alone or combined with Western medicine (WM) or physiotherapy

controlled by untreated

placebo or WM treatment were found in electronic databases

including PubMed/MEDLINE

EMBASE

Cochrane Library

Cochrane Central Register of Controlled Trials

China Biology Medicine Disc (CBM)

Chinese National Knowledge Infrastructure (CNKI)

Wanfang database and VIP database from their inception through July 2011. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. A total of 10 randomized trials (involving 1

435 patients) were included. Because both test and control drugs used in the RCTs were different from each other

the effects can only be described singly and calculated. Regarding the total effective rate for the treatment of psoriasis

ex-CHD in combination with ultraviolet radiation b (UVB) or narrow band ultraviolet radiation b (NB-UVB)

which was reported in 6 trials

was superior to UVB alone. One study reported that ex-CHD and externally applied WM had equivalent effects. In another study

ex-CHD showed better results than placebo. However

another two comparisons of ex-CHD and WM (all in combining with oral WM) showed uncertain outcomes. Nine trials reported adverse reactions. Of these

7 RCTs included statistical analysis. The results showed that the side-effects that occurred in ex-CHD combined with UVB were less severe than those caused by UVB alone

but the incidence was roughly the same as WM. The evidence supporting the efficacy of ex-CHD with respect to treating psoriasis is quite limited and must be strengthened by high-quality studies.

关键词

psoriasisChinese Medicineexternal treatmentrandomized controlled trialsystematic review

Keywords

psoriasisChinese Medicineexternal treatmentrandomized controlled trialsystematic review

references

Zhao B, ed. Clinical dermatology. 1st ed. Nanjing: Jiangsu Science and Technology Press; 2009:1008–1021.

Gelfand JM, Weinstein R, Porter SB, Neimann AL, Berlin JA, Margolis DJ. Prevalence and treatment of psoriasis in the United Kingdom: a population-based study. Arch Dermatol 2005;141:1537–1541.

Gelfand JM, Stern RS, Nijsten T, Feldman SR, Thomas J, Kist J, et al. The prevalence of psoriasis in African Americans: results from a population-based. J Am Acad Dermatol 2005;52:23–26.

Yip SY. The prevalence of psoriasis in the Mongoloid race. J Am Acad Dermatol 1984;10:965–968.

Ding XL, Wang TL, Shen YW, Wang XY, Zhou C, Tian S. Prevalence of psoriasis in China: an epidemiological survey in six provinces. Chin J Dermatol Venereol (Chin) 2010; 24:598–601.

Christophers E, Griffiths CE, Gaitanis G, van de Kerkhof P. The unmet treatment need for moderate to severe psoriasis: results of a survey and chart review. J Eur Acad Dermatol Venereol 2006;20:921–925.

Zheng XY. Guiding principle of clinical research on new drugs of traditional Chinese medicine. Beijing: China Medical Science and Technology Press;2002:299–300.

Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions version 5.1.0 [updated March 2011]. Oxford: The Cochrane Library. 2011.

Zhou M, Huang GY. Clinical observation of Shu Fu Powder bath combined long-wave UVA treatment of psoriasis vulgaris. Liaoning J Tradit Chin Med (Chin) 2005;32(10):44–45.

Gu Y, Liu HX, Zhang CH, Liu ZX, Yao SP, Feng L, et al. Clinical observation of traditional Chinese medical herbs bath combined with narrow-band ultraviolet B for the treatment of psoriasis vulgaris. Chin J Dermatol Venereol (Chin) 2009;23:243–244, Suppl 4.

Cui BN, Sun YX, Liu WL. Clinical efficacy of narrow band ultraviolet B combined with Yuyin Recipe in treating psoriasis vulgaris. Chin J Integr Tradit Chin Med (Chin) 2008;28:355–357.

Zhang CM, Wei G, Zhang CH, Pang L, Shi YJ, Cai Y. Clinical efficacy of Chinese medicine fumigation combined ultraviolet radiation in treating psoriasis vulgaris and its effect on the psoriasis serum Th1/Th2 type cytokines. Chin J Phys Med Rehabil (Chin) 2009;31:491–492.

Wu LN, Huang LN, Xue RZ. Clinical observation and nursing of psoriasis vulgaris treated with narrow-band UVB combined with Chinese herb bath. J Diagn Ther Dermatol Venereol (Chin) 2010;3:242–244.

Chen SJ, Wu XT, Yao CH, Liu QY, Li YF, Song YL. Curative effect and safety of narrow-band ultraviolet B phototherapy combined with Qingpeng Ointment on psoriasis vulgaris. Contemp Med (Chin) 2010;30:5–6.

Gao WY, Zhang W, Yang YD, Zhou CY, Bai YM. Clinical study of chinese medicine Liubai Baibi Ointment for the treatment of psoriasis vulgaris. J Extern Ther Tradit Chin Med (Chin) 2006;15(2):26–27.

Su BB, Yu JB, Zhang JA, Zhai W, Gao M. Observation of curative effect of Binghuang Fule Ointment combined with compound glycyrrhizin in the treatment of psoriasis vulgaris. Chin J Dermatol Venereol (Chin) 2009;23:125–126.

Zhu L, Zhang H, Duan YJ. Clinical observation of 85 cases of psoriasis vulgaris with Chinese medicine “Xiaoxuanling”. Youjiang Med J (Chin) 2008;36:230–231.

Lin YG, Wu YH, Yang RJ, Su ZH, Yang XH. Clinical observation on psoriasis treated by complex prescription Qingdai Basilicon. J Chengdu Univ Tradit Chin Med (Chin) 2006;29(2):13–16.

Krueger G, Ellis CN. Psoriasis—recent advances in understanding its pathogenesis and treatment. J Am Acad Dermatol 2005;53(1 Suppl):S94–S100.

Basra MK, Fenech R, Gatt RM, Salek MS, Finlay AY. The Dermatology Life Quality Index 1994–2007: a comprehensive review of validation data and clinical results. Br J Dermatol 2008;159:997–1035.

Yan HB, Li W, Andrew YF. Measures of disease severity and life quality in patients with psoriasis. Int J Dermatol Venereol 2009;35:306–308.

Special Committee of Dermatology, Association of Chinese Medicine of PLA. Consensus on integrative medicine diagnosis and treatment of psoriasis vulgaris” (2009). Chin J Dermatol Venereol Integr Tradit West Med (Chin) 2009;8:328.

FULL TEXT LINK

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Astragalus membranaceus Injection combined with conventional treatment for viral myocarditis: A systematic review of randomized controlled trials

Efficacy and safety of Flos Abelmoschus manihot (Malvaceae) on type 2 diabetic nephropathy: A systematic review

Shenqi Fuzheng Injection (参芪扶正注射液) for advanced gastric cancer: A systematic review of randomized controlled trials

Tongxinluo Capsule (通心络胶囊) for Cardiac Syndrome X: A Systematic Review and Meta-Analysis

Toward Evidence-Based Chinese Medicine: Status Quo, Opportunities and Challenges

Related Author

No data

Related Institution

Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases

Division of Infectious Diseases, Chinese PLA Hospital

Department of Nephrology, Zhongshan Hospital, Xiamen University

Evidence-Based Medicine Center, College of Basic Medicine, Lanzhou University

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰