Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats

Hai-hong Zhou; Shao-dong Chen; Yin Xu; Yong-zhu Han; Ji-yuan Hu

doi:10.1007/s11655-012-1024-z

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Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats

Updated：2021-08-27

- Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats
- Chinese Journal of Integrative Medicine Vol. 19, Issue 3, Pages: 200-205(2013)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Medical College of Xiamen University,Fujian Province,Xiamen,China
  2. Institute of Neurology, Anhui University of Traditional Chinese Medicine,Hefei,China
- Author bio：
- Funds：
  
  Supported by the Science Foundation of Fujian Province (No. 2010J01239), the Xiamen Science and Technology Key Program Grant (No. 3502Z20100006) and Hong Kong Healthy Walker Co., Ltd (No. XDTH2009023A)
- DOI：10.1007/s11655-012-1024-z
  CLC：
- Published：2013，
  
  Published Online：14 March 2012，
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Zhou, Hh., Chen, Sd., Xu, Y. et al. Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats., Chin. J. Integr. Med. 19, 200–205 (2013). https://doi.org/10.1007/s11655-012-1024-z

Hai-hong Zhou, Shao-dong Chen, Yin Xu, et al. Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats. [J]. Chinese Journal of Integrative Medicine 19(3):200-205(2013)
Zhou, Hh., Chen, Sd., Xu, Y. et al. Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats., Chin. J. Integr. Med. 19, 200–205 (2013). https://doi.org/10.1007/s11655-012-1024-z DOI：

Hai-hong Zhou, Shao-dong Chen, Yin Xu, et al. Multiple pharmacological actions of Yiqi Huatan Decoction (益气化痰方) in a model of depression in rats. [J]. Chinese Journal of Integrative Medicine 19(3):200-205(2013) DOI： 10.1007/s11655-012-1024-z.

摘要

To investigate the influence of Yiqi Huatan Decoction (益气化痰方

YHD) on a model of depression in rats under different pathological conditions. Thirty-two male SD rats were randomly divided into 4 groups of 8: normal

model

YHD

and maprotiline. The model group

YHD group and maprotiline group used separate feeding and rats were exposed to chronic and unpredictable stress to build the depression model. From day 2

the YHD group and maprotiline group were respectively given YHD (7 g/kg) and maprotiline (10 mg/kg) by gastrogavage once daily. The normal and model groups were given the same volume of drinking water. The medication duration were 21 days. At the end of the experiment

the serum levels of copper and zinc were determined by atomic absorption spectroscopy

plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol (COR) were detected by radioimmunoassay

and levels of norepinephrine (NE)

dopamine (DA)

and 5-hydroxytryptamine (5-HT) in the hypothalamus were analysed by high performance liquid chromatography-eletricochemistry. Compared with the content of copper and zinc in the serum of rats in the normal group

serum copper levels in model rats were significantly increased and zinc content was significantly reduced (both P<0.05). Plasma concentrations of ACTH and COR in the model group were significantly increased compared with those in the normal group (P<0.05

P<0.01). The contents of NE

and 5-HT in the hypothalamus of rats in the model group were significantly reduced compared with those of the normal group (P<0.05 or P<0.01). Compared with those in the model group

the serum copper content and plasma concentrations of ACTH and COR were significantly decreased (all P<0.05); meanwhile

serum zinc content and hypothalamic contents of NE

and 5-HT were significantly increased in rats of the YHD group (all P<0.05). The same effects were also shown in the maprotiline group except for 5-HT (all P<0.05) The pharmacological actions of YHD for depression might be related to improving trace-element anomalies

reversing endocrine dysfunction

and modulating the disorders of monoaminergic neurotransmitters.

Abstract

To investigate the influence of Yiqi Huatan Decoction (益气化痰方

YHD) on a model of depression in rats under different pathological conditions. Thirty-two male SD rats were randomly divided into 4 groups of 8: normal

model

YHD

and maprotiline. The model group

YHD group and maprotiline group used separate feeding and rats were exposed to chronic and unpredictable stress to build the depression model. From day 2

the serum levels of copper and zinc were determined by atomic absorption spectroscopy

plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol (COR) were detected by radioimmunoassay

and levels of norepinephrine (NE)

dopamine (DA)

P<0.01). The contents of NE

and 5-HT in the hypothalamus of rats in the model group were significantly reduced compared with those of the normal group (P<0.05 or P<0.01). Compared with those in the model group

the serum copper content and plasma concentrations of ACTH and COR were significantly decreased (all P<0.05); meanwhile

serum zinc content and hypothalamic contents of NE

reversing endocrine dysfunction

and modulating the disorders of monoaminergic neurotransmitters.

关键词

Yiqi Huatan Decoctiondepressionendocrine dysfunctiontrace-element anomaliesdisorders of monoamine neurotransmitters

Keywords

Yiqi Huatan Decoctiondepressionendocrine dysfunctiontrace-element anomaliesdisorders of monoamine neurotransmitters

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Jiangsu Hospital of Chinese Medicine

Basic Medical College of Nanjing University of Chinese Medicine

The Second Clinical College of Nanjing University of Chinese Medicine

Cultivating Candidate of the State Key Laboratory of Integrated Acupuncture and Medication, Nanjing University of Chinese Medicine

Traditional Chinese Medicine Research and Development Center, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

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