Pinching spine: A potential treatment for depression

Li-hua Jiang; Ling-ling Wang; Ming-yan Wang; Hao-xin Wu; Yi-jie Zou; Xiao-lin Yuan; Mei-juan Chen

doi:10.1007/s11655-012-1028-8

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Pinching spine: A potential treatment for depression

Updated：2021-08-27

- Pinching spine: A potential treatment for depression
- Chinese Journal of Integrative Medicine Vol. 20, Issue 4, Pages: 272-279(2014)
- Affiliations：
  
  1. Cultivating Candidate of the State Key Laboratory of Integrated Acupuncture and Medication, Nanjing University of Chinese Medicine,Nanjing,China
  2. The Second Clinical College of Nanjing University of Chinese Medicine,Nanjing,China
  3. Basic Medical College of Nanjing University of Chinese Medicine,Nanjing,China
  4. Jiangsu Hospital of Chinese Medicine,Nanjing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1028-8
  CLC：
- Published：2014，
  
  Published Online：21 March 2012，
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Jiang, Lh., Wang, Ll., Wang, My. et al. Pinching spine: A potential treatment for depression., Chin. J. Integr. Med. 20, 272–279 (2014). https://doi.org/10.1007/s11655-012-1028-8

Li-hua Jiang, Ling-ling Wang, Ming-yan Wang, et al. Pinching spine: A potential treatment for depression. [J]. Chinese Journal of Integrative Medicine 20(4):272-279(2014)
Jiang, Lh., Wang, Ll., Wang, My. et al. Pinching spine: A potential treatment for depression., Chin. J. Integr. Med. 20, 272–279 (2014). https://doi.org/10.1007/s11655-012-1028-8 DOI：

Li-hua Jiang, Ling-ling Wang, Ming-yan Wang, et al. Pinching spine: A potential treatment for depression. [J]. Chinese Journal of Integrative Medicine 20(4):272-279(2014) DOI： 10.1007/s11655-012-1028-8.

摘要

To investigate whether pinching spine (PS

i.e. 捏脊

a traditional Chinese manipulative therapy) is beneficial to ameliorating the depressive state (including behavioral deficit

retardative weight gain and decreased sucrose consumption) in a rat model of depression induced by chronic unpredictable stress (CUS) and to explore the candidate mechanism of action. PS was performed on rats’ spine once daily for 1 week after exposure to CUS. The open-field test

body weight measuring

and sucrose intake test were applied on different dates: before stress (d0)

at the end of stress (d21) and after PS treatment (d28)

respectively. Then the rats’ hippocampuses were performed genome-wide microarray analysis

and the expression levels of several genes were evaluated by real-time polymerase chain reaction (PCR). Exposure to CUS resulted in decreases of behavioral activity and sucrose consumption

which were reversed significantly after PS treatment. The expression of several genes relevant to energy metabolism

anti-oxidation

and olfactory receptor

etc.

were down-regulated

while the expression of those relevant to hemostasis

immunity-inflammation

and restriction of activities and ingestion

etc.

were up-regulated in hippocampuses of rats exposed to CUS. PS treatment significantly inverted these changes. Furthermore

increase or decrease in gene expression evaluated by realtime PCR was concordant with up-regulated or down-regulated expression evaluated by microarray analysis. PS showed a potential antidepressant-like effect

of which the action mechanism might be due to gene expression regulation in hippocampus.

Abstract

To investigate whether pinching spine (PS

i.e. 捏脊

a traditional Chinese manipulative therapy) is beneficial to ameliorating the depressive state (including behavioral deficit

body weight measuring

and sucrose intake test were applied on different dates: before stress (d0)

at the end of stress (d21) and after PS treatment (d28)

respectively. Then the rats’ hippocampuses were performed genome-wide microarray analysis

and the expression levels of several genes were evaluated by real-time polymerase chain reaction (PCR). Exposure to CUS resulted in decreases of behavioral activity and sucrose consumption

which were reversed significantly after PS treatment. The expression of several genes relevant to energy metabolism

anti-oxidation

and olfactory receptor

etc.

were down-regulated

while the expression of those relevant to hemostasis

immunity-inflammation

and restriction of activities and ingestion

etc.

were up-regulated in hippocampuses of rats exposed to CUS. PS treatment significantly inverted these changes. Furthermore

of which the action mechanism might be due to gene expression regulation in hippocampus.

关键词

pinching spinedepressionchronic unpredictable stress

Keywords

pinching spinedepressionchronic unpredictable stress

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Traditional Chinese Medicine Research and Development Center, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Institute of Neurology, Anhui University of Traditional Chinese Medicine

Department of Traditional Chinese Medicine, Medical College of Xiamen University

Department of Social Work and Social Administration, the University of Hong Kong

Department of Psychology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

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