Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits

Min-jian Zhang; Ya-lei Shi; Wan-jun Cheng; Zhen-wei Li; Xiang Lin

doi:10.1007/s11655-012-1088-9

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Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits

Updated：2021-08-27

- Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits
- Chinese Journal of Integrative Medicine Vol. 20, Issue 6, Pages: 420-424(2014)
- Affiliations：
  
  People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Fujian Province (No. 2008J0092)
- DOI：10.1007/s11655-012-1088-9
  CLC：
- Published：2014，
  
  Published Online：19 May 2012，
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Zhang, Mj., Shi, Yl., Cheng, Wj. et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits., Chin. J. Integr. Med. 20, 420–424 (2014). https://doi.org/10.1007/s11655-012-1088-9

Min-jian Zhang, Ya-lei Shi, Wan-jun Cheng, et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits. [J]. Chinese Journal of Integrative Medicine 20(6):420-424(2014)
Zhang, Mj., Shi, Yl., Cheng, Wj. et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits., Chin. J. Integr. Med. 20, 420–424 (2014). https://doi.org/10.1007/s11655-012-1088-9 DOI：

Min-jian Zhang, Ya-lei Shi, Wan-jun Cheng, et al. Relaxant effects of Aike Mixture (艾可合剂) on isolated bladder and prostatic urethral smooth muscle of rabbits. [J]. Chinese Journal of Integrative Medicine 20(6):420-424(2014) DOI： 10.1007/s11655-012-1088-9.

摘要

To observe the relaxant effect of Aike Mixture (艾可合剂

AKM) on isolated bladder and prostatic urethral smooth muscle of rabbits. The isolated bladder and prostatic urethral smooth muscle from male rabbits were placed in a Magnus bath and smooth muscle contraction was measured using a biological signal acquisition and analysis system. The effects of AKM in combination with methoxyamine

carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle (r=0.831

P<0.05)

reduced contractile wave amplitude (r=0.837

P<0.05) and decreased contractile frequency (r=−0.917

P<0.01). AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine

carbachol and CaCl2. AKM dose-dependently inhibited the contraction of rabbit isolated bladder and prostatic urethral smooth muscle by antagonizing α1-adrenergic receptors and M-cholinergic receptors.

Abstract

To observe the relaxant effect of Aike Mixture (艾可合剂

carbachol and CaCl2 on the contractile tension of muscle strips were determined by cumulative dosing. AKM dose-dependently reduced contractile tension of bladder trigone smooth muscle (r=0.831

P<0.05)

reduced contractile wave amplitude (r=0.837

P<0.05) and decreased contractile frequency (r=−0.917

P<0.01). AKM significantly inhibited the increases in smooth muscle contraction induced by methoxyamine

关键词

Aike Mixturebladder smooth muscleurethral smooth muscleα1-adrenergic receptorM-cholinergic receptorCa2+ channel

Keywords

Aike Mixturebladder smooth muscleurethral smooth muscleα1-adrenergic receptorM-cholinergic receptorCa2+ channel

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