Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf

Jing-shang Wang; Hui-jun Yin; Chun-Yu Guo; Ye Huang; Cheng-dong Xia; Qian Liu

doi:10.1007/s11655-012-1093-z

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Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf

Updated：2021-08-27

- Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf
- Chinese Journal of Integrative Medicine Vol. 19, Issue 3, Pages: 217-222(2013)
- Affiliations：
  
  Departmten of Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Science,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81041038)
- DOI：10.1007/s11655-012-1093-z
  CLC：
- Published：2013，
  
  Published Online：19 May 2012，
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Wang, Js., Yin, Hj., Guo, CY. et al. Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf., Chin. J. Integr. Med. 19, 217–222 (2013). https://doi.org/10.1007/s11655-012-1093-z

Jing-shang Wang, Hui-jun Yin, Chun-Yu Guo, et al. Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf. [J]. Chinese Journal of Integrative Medicine 19(3):217-222(2013)
Wang, Js., Yin, Hj., Guo, CY. et al. Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf., Chin. J. Integr. Med. 19, 217–222 (2013). https://doi.org/10.1007/s11655-012-1093-z DOI：

Jing-shang Wang, Hui-jun Yin, Chun-Yu Guo, et al. Influence of high blood glucose fluctuation on endothelial function of type 2 diabetes mellitus rats and effects of Panax Quinquefolius Saponin of stem and leaf. [J]. Chinese Journal of Integrative Medicine 19(3):217-222(2013) DOI： 10.1007/s11655-012-1093-z.

摘要

To observe the influence of high blood glucose fluctuation on the endothelial function of type 2 diabetes mellitus (T2DM) rats and the effects of Panax Quinquefolius Saponin (PQS) of stem and leaf. The T2DM model was induced by intraperitoneal injection of a small dose of streptozotocin (STZ

35 mg/kg) plus high fat and high caloric laboratory chow. Then

diabetic rats were divided into steady high blood glucose (SHG) group and fluctuant high blood glucose (FHG) group according to fasting blood glucose coefficient of variation (FBG-CV)

and then

the FHG group rats were divided into 4 groups according to the level of FBG-CV and fasting blood glucose: PQS 30 mg/(kg·d) group

PQS 60 mg/(kg·d) group

metformin hydrochloride control (MHC) group

and FHG control group

10 in each group. Meanwhile

10 rats without any treatment were used as normal control (NOR) group. Eight weeks later

the aortic arteries histology

plasma hepatocyte growth factor (HGF)

and serum nitric oxide (NO)

endothelin-1 (ET-1)

tumor necrosis factor α (TNF-α)

and soluble intercellular adhesion molecule 1 (sICAM-1) were measured. In comparison with the NOR group

the level of plasma HGF and serum NO

ET-1 and TNF-α

and sICAM-1 in SHG and FHG control groups were all significantly increased (P<0.01); in comparison with the SHG group

plasma HGF and serum NO

ET-1

TNF-α

and sICAM-1 in FHG group were all significantly increased further (P<0.01 or P<0.05); meanwhile

in comparison with the FHG control group

the level of plasma HGF and serum NO

ET-1

TNF-α

and sICAM-1 in PQS and MHC groups were all decreased significantly (P<0.01). However

comparison of the aortic arteries histology among groups showed no significant differences either before or after treatment. Blood glucose fluctuation could facilitate the development of vascular endothelial dysfunction in T2DM rats

while PQS could improve the endothelial function of T2DM rats with high blood glucose fluctuation

which may be related to its effects of relieving vessel stress

decreasing vasoconstrictor ET-1 production

preventing compensated increase of NO

and reducing inflammatory reaction.

Abstract

35 mg/kg) plus high fat and high caloric laboratory chow. Then

diabetic rats were divided into steady high blood glucose (SHG) group and fluctuant high blood glucose (FHG) group according to fasting blood glucose coefficient of variation (FBG-CV)

and then

the FHG group rats were divided into 4 groups according to the level of FBG-CV and fasting blood glucose: PQS 30 mg/(kg·d) group

PQS 60 mg/(kg·d) group

metformin hydrochloride control (MHC) group

and FHG control group

10 in each group. Meanwhile

10 rats without any treatment were used as normal control (NOR) group. Eight weeks later

the aortic arteries histology

plasma hepatocyte growth factor (HGF)

and serum nitric oxide (NO)

endothelin-1 (ET-1)

tumor necrosis factor α (TNF-α)

and soluble intercellular adhesion molecule 1 (sICAM-1) were measured. In comparison with the NOR group

the level of plasma HGF and serum NO

ET-1 and TNF-α

and sICAM-1 in SHG and FHG control groups were all significantly increased (P<0.01); in comparison with the SHG group

plasma HGF and serum NO

ET-1

TNF-α

and sICAM-1 in FHG group were all significantly increased further (P<0.01 or P<0.05); meanwhile

in comparison with the FHG control group

the level of plasma HGF and serum NO

ET-1

TNF-α

and sICAM-1 in PQS and MHC groups were all decreased significantly (P<0.01). However

while PQS could improve the endothelial function of T2DM rats with high blood glucose fluctuation

which may be related to its effects of relieving vessel stress

decreasing vasoconstrictor ET-1 production

preventing compensated increase of NO

and reducing inflammatory reaction.

关键词

high blood glucose fluctuationendothelial functiontype 2 diabetes mellitusAmerican Ginseng

Keywords

high blood glucose fluctuationendothelial functiontype 2 diabetes mellitusAmerican Ginseng

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