Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model

Dan-hui Yi; Yang Li; Shu-xin Shao; Yan-ming Xie; Ya Yuwen

doi:10.1007/s11655-012-1095-x

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Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model

Updated：2021-08-27

- Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model
- Chinese Journal of Integrative Medicine Vol. 19, Issue 8, Pages: 629-635(2013)
- Affiliations：
  
  1. Center for Applied Statistics, Renmin University of China,Beijing,China
  2. International College (Suzhou Research Institute), Renmin University of China,Jiangsu Province,Suzhou,China
  3. School of Statistics, Renmin University of China,Beijing,China
  4. School of Public Health, Yale University,New Haven,USA
  5. Graduate School of Business, Columbia University,New York,USA
  6. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National High-Tech Research and Development Program (No. 2007AA02Z4B2), National Key Technologies Research and Development Program (No. 2006BAI08B05-09), Key Research Institute of Humanities and Social Sciences Program (No. 2009JJD910002), and Research Supporting Fund for Graduates by Renmin University of China (No. 08XNH061)
- DOI：10.1007/s11655-012-1095-x
  CLC：
- Published：2013，
  
  Published Online：26 April 2012，
Scan for full text
Yi, Dh., Li, Y., Shao, Sx. et al. Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model., Chin. J. Integr. Med. 19, 629–635 (2013). https://doi.org/10.1007/s11655-012-1095-x

Dan-hui Yi, Yang Li, Shu-xin Shao, et al. Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model. [J]. Chinese Journal of Integrative Medicine 19(8):629-635(2013)
Yi, Dh., Li, Y., Shao, Sx. et al. Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model., Chin. J. Integr. Med. 19, 629–635 (2013). https://doi.org/10.1007/s11655-012-1095-x DOI：

Dan-hui Yi, Yang Li, Shu-xin Shao, et al. Evaluation of the conjoint efficacy in Chinese medicine with the longitudinal latent variable linear mixed model. [J]. Chinese Journal of Integrative Medicine 19(8):629-635(2013) DOI： 10.1007/s11655-012-1095-x.

摘要

Chinese medicine (CM) clinical efficacy evaluation research involves the longitudinal multivariate measurement which means that patients are measured repeatedly and each patient is measured by several indicators on each fixed cross-section. Although each indicator can be evaluated separately with a longitudinal linear mixed model

it is important to consider all the endpoints together especially when researchers pay special attention to the change of the conjoint efficacy for several indicators in one patient. In this article

we introduce a latent variable linear mixed model to the CM conjoint efficacy evaluation and discuss why and how to analyze the longitudinal multivariate endpoint data in the clinical CM efficacy evaluation research. It may lead to the new insight of using such methodology in the field of conjoint efficacy evaluating of CM study. And with the definition of syndrome and symptom in the CM theory

the applied discussion brings the insight of CM syndrome evaluating in future. We illustrate this methodology using an example of CM efficacy evaluation from an ischemic stroke research.

Abstract

it is important to consider all the endpoints together especially when researchers pay special attention to the change of the conjoint efficacy for several indicators in one patient. In this article

the applied discussion brings the insight of CM syndrome evaluating in future. We illustrate this methodology using an example of CM efficacy evaluation from an ischemic stroke research.

关键词

Chinese Medicineefficacy evaluationmultiple endpointslongitudinal datalatent variableischemic stroke

Keywords

Chinese Medicineefficacy evaluationmultiple endpointslongitudinal datalatent variableischemic stroke

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Medical Informatics Center, Peking University

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Neurology Department of Peking University First Hospital, Peking University

School of Public Health, Peking University Health Science Center, Peking University

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