Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine

Zhi-zhong Wang; Yong-fei Fang; Yong Wang; Fang-xiang Mu; Jun Chen; Qing-hua Zou; Bing Zhong; Jing-yi Li; Gan-ping Bo; Rong-hua Zhang

doi:10.1007/s11655-012-1172-1

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Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine

Updated：2021-08-27

- Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine
- Chinese Journal of Integrative Medicine Vol. 18, Issue 8, Pages: 575-581(2012)
- Affiliations：
  
  1. Department of Rheumatology, Southwest Hospital, Third Military Medical University,Chongqing,China
  2. Department of Health Statistics, Third Military Medical University,Chongqing,China
- Author bio：
- Funds：
  
  supported by the Scientific Program of Traditional Chinese Medicine of Chongqing Municipal Health Bureau, China (2008-1-15) and the National Natural Science Foundation of China (No. 30973827)
- DOI：10.1007/s11655-012-1172-1
  CLC：
- Published：2012，
  
  Published Online：2 August 2012，
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Wang, Zz., Fang, Yf., Wang, Y. et al. Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine., Chin. J. Integr. Med. 18, 575–581 (2012). https://doi.org/10.1007/s11655-012-1172-1

Zhi-zhong Wang, Yong-fei Fang, Yong Wang, et al. Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine. [J]. Chinese Journal of Integrative Medicine 18(8):575-581(2012)
Wang, Zz., Fang, Yf., Wang, Y. et al. Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine., Chin. J. Integr. Med. 18, 575–581 (2012). https://doi.org/10.1007/s11655-012-1172-1 DOI：

Zhi-zhong Wang, Yong-fei Fang, Yong Wang, et al. Logistic regression analysis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis: A perspective in Chinese medicine. [J]. Chinese Journal of Integrative Medicine 18(8):575-581(2012) DOI： 10.1007/s11655-012-1172-1.

摘要

To investigate a method for quantitative differential diagnosis of damp-heat and cold-damp impeding syndrome of rheumatoid arthritis (RA) in Chinese medicine (CM). Laboratory parameters were collected from 306 patients with RA. The clinical symptoms and laboratory parameters were compared between patients with these two syndromes (158 with RA of damp-heat impeding syndrome

and 148 with RA of cold-damp impeding syndrome)

and a regression equation was established to facilitate discrimination of the two RA syndromes. There were significant differences in disease activity score in 28 joints [DAS28 (4)]

erythrocyte sedimentation rate (ESR)

white blood cell count (WBC)

C-reactive protein (CRP)

platelet count (PLT)

albumin (ALB) and globulin (GLB) between the two syndrome of RA (P<0.05). Logistic regression analysis showed that the parameters ESR

WBC

CRP

joint pyrexia

joint cold

thirst

sweating

aversion to wind and cold

and cold extremities were statistically useful to discriminate damp-heat from cold-damp impeding syndrome. The regression equation was as follows: P=1/{1+exp[-(3.0-0.021X 1-0.196X 2-0.163X 3-1.559X 4+1.504X 5-0.927X 6-1.039X 7+1.070X 8+1.330X 9)]}. The independent variables X 1-X 9 were ESR

WBC

CRP

hot joint

cold joint

thirst

sweating

aversion to wind and cold

and cold limbs. A P value > 0.5 signified cold-damp impeding syndrome

and a P value < 0.5 signified damp-heat impeding syndrome. The accuracy was 90.2%. The regression equation may be useful for discriminating damp-heat from cold-damp impeding syndrome of RA.

Abstract

and 148 with RA of cold-damp impeding syndrome)

and a regression equation was established to facilitate discrimination of the two RA syndromes. There were significant differences in disease activity score in 28 joints [DAS28 (4)]

erythrocyte sedimentation rate (ESR)

white blood cell count (WBC)

C-reactive protein (CRP)

platelet count (PLT)

albumin (ALB) and globulin (GLB) between the two syndrome of RA (P<0.05). Logistic regression analysis showed that the parameters ESR

WBC

CRP

joint pyrexia

joint cold

thirst

sweating

aversion to wind and cold

WBC

CRP

hot joint

cold joint

thirst

sweating

aversion to wind and cold

and cold limbs. A P value > 0.5 signified cold-damp impeding syndrome

and a P value < 0.5 signified damp-heat impeding syndrome. The accuracy was 90.2%. The regression equation may be useful for discriminating damp-heat from cold-damp impeding syndrome of RA.

关键词

logistic regressiondamp-heat impeding syndromecold-damp impeding syndromerheumatoid arthritisquantitative diagnosis

Keywords

logistic regressiondamp-heat impeding syndromecold-damp impeding syndromerheumatoid arthritisquantitative diagnosis

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