A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

Ding-quan Yang; Li-ping You; Pei-hua Song; Li-xin Zhang; Yan-ping Bai

doi:10.1007/s11655-012-1173-0

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A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata

Updated：2021-08-27

- A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata
- Chinese Journal of Integrative Medicine Vol. 18, Issue 8, Pages: 621-625(2012)
- Affiliations：
  
  Department of Dermatology, China-Japan Friendship Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1173-0
  CLC：
- Published：2012，
  
  Published Online：2 August 2012，
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Yang, Dq., You, Lp., Song, Ph. et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata., Chin. J. Integr. Med. 18, 621–625 (2012). https://doi.org/10.1007/s11655-012-1173-0

Ding-quan Yang, Li-ping You, Pei-hua Song, et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata. [J]. Chinese Journal of Integrative Medicine 18(8):621-625(2012)
Yang, Dq., You, Lp., Song, Ph. et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata., Chin. J. Integr. Med. 18, 621–625 (2012). https://doi.org/10.1007/s11655-012-1173-0 DOI：

Ding-quan Yang, Li-ping You, Pei-hua Song, et al. A randomized controlled trial comparing total glucosides of paeony capsule and compound glycyrrhizin tablet for alopecia areata. [J]. Chinese Journal of Integrative Medicine 18(8):621-625(2012) DOI： 10.1007/s11655-012-1173-0.

摘要

To observe the efficacy and safety of total glucosides of paeony capsule (TGPC) in patients with mild and moderate alopecia areata. A total of 86 outpatients were randomly allocated into two groups of TGPC (treatment

44 cases) and compound glycyrrhizin tablet (control

42 cases). The treatment group was given oral TGPC

three times daily and 600 mg per time; the control group was given oral compound glycyrrhizin tablets

three times daily and 50 mg per time. In addition

both groups were given 10 mg of vitamin B2 and tapped the bold patches with massage. The treatment course was three months for both groups. Peripheral blood T-cell subsets (CD3+CD4+

CD3+CD8+

Th/Ts) of 10 patients randomly selected from each group respectively were tested before and after three months of treatment. The effectiveness and adverse reaction of all cases were observed each month. The safety was evaluated according to the incidence rate of adverse reaction. In the treatment group

the cured and markedly effective rate was 36.36% (16/44)

50.00% (22/44) and 68.18% (30/44) at the end of first

second and third month of treatment

respectively

and the incidence rate of adverse reaction was 13.64% (6/44). In the control group

the cured and markedly effective rate was 38.10% (16/42)

57.14% (24/42) and 71.43% (30/42)

respectively

and the incidence rate of adverse reaction was 16.67% (7/42). The cured and markedly effective rate and the incidence rate of adverse reaction were similar in both groups (P>0.05). TGPC and compound glycyrrhizin tablet can inhibit CD3+CD4+ and CD3+CD8+

and decrease the ratio of Th/Ts (P<0.05). TGPC is effective and safe in the treatment of alopecia areata.

Abstract

44 cases) and compound glycyrrhizin tablet (control

42 cases). The treatment group was given oral TGPC

three times daily and 600 mg per time; the control group was given oral compound glycyrrhizin tablets

three times daily and 50 mg per time. In addition

both groups were given 10 mg of vitamin B2 and tapped the bold patches with massage. The treatment course was three months for both groups. Peripheral blood T-cell subsets (CD3+CD4+

CD3+CD8+

the cured and markedly effective rate was 36.36% (16/44)

50.00% (22/44) and 68.18% (30/44) at the end of first

second and third month of treatment

respectively

and the incidence rate of adverse reaction was 13.64% (6/44). In the control group

the cured and markedly effective rate was 38.10% (16/42)

57.14% (24/42) and 71.43% (30/42)

respectively

and decrease the ratio of Th/Ts (P<0.05). TGPC is effective and safe in the treatment of alopecia areata.

关键词

total glucosides of paeony capsulecompound glycyrrhizin tabletsT-cell subsetsalopecia areata

Keywords

total glucosides of paeony capsulecompound glycyrrhizin tabletsT-cell subsetsalopecia areata

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