Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats

Li-heng Guo; Cheng Yang; Lei Wang; Quan-fu Chen; Ya-nan Hu; Min-zhou Zhang

doi:10.1007/s11655-012-1175-y

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Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats

Updated：2021-08-27

- Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats
- Chinese Journal of Integrative Medicine Vol. 18, Issue 8, Pages: 610-615(2012)
- Affiliations：
  
  Intensive Care Unit, Guangdong Province Hospital of Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the Fund for Social Development Project from Department of Science and Technology, Guangdong Province, China (No. 2011KT1988)
- DOI：10.1007/s11655-012-1175-y
  CLC：
- Published：2012，
  
  Published Online：2 August 2012，
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Guo, Lh., Yang, C., Wang, L. et al. Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats., Chin. J. Integr. Med. 18, 610–615 (2012). https://doi.org/10.1007/s11655-012-1175-y

Li-heng Guo, Cheng Yang, Lei Wang, et al. Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats. [J]. Chinese Journal of Integrative Medicine 18(8):610-615(2012)
Guo, Lh., Yang, C., Wang, L. et al. Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats., Chin. J. Integr. Med. 18, 610–615 (2012). https://doi.org/10.1007/s11655-012-1175-y DOI：

Li-heng Guo, Cheng Yang, Lei Wang, et al. Effects of tetramethylpyrazine on cardiac function and mortality rate in septic rats. [J]. Chinese Journal of Integrative Medicine 18(8):610-615(2012) DOI： 10.1007/s11655-012-1175-y.

摘要

To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats. Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group

n=10)

normal saline group (NS group

n=20)

and TMP group (n=20). The rats in the NS and TMP groups underwent cecal ligation and puncture (CLP) to induce sepsis. Rats in the NS group were injected with NS (10 mL/kg) immediately after CLP and 6 h after CLP. Rats in the TMP group were injected with TMP (10 mg/kg) at the same time points. Twenty-four hours after modeling

the mortality rates were observed in each group. Cardiac function and serum concentration of tumor necrosis factor α (TNF-α) were also tested. The correlation between TNF-α and the ejection fraction (EF) was observed. Left ventricle specimens were reserved for histomorphologic study. Compared with the sham group

the NS and TMP groups had decreased EF values and increased mortality rates and serum TNF-α levels (P <0.05). The TMP group had a comparatively lower mortality rate and TNF-α level and a higher EF value compared with the NS group (P <0.05). Histomorphology indicated that myocardial inflammation in the TMP group was mild compared with that in the NS group. There was a negative correlation between TNF-α level and EF value (r=−0.583

P=0.000). TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function.

Abstract

To study the effects of tetramethylpyrazine (TMP) on cardiac function and mortality rate in septic rats. Fifty male Sprague-Dawley rats were randomized into a sham-operation group (sham group

n=10)

normal saline group (NS group

n=20)

P=0.000). TMP could reduce the mortality rate of septic rats and had certain protective effects on cardiac function.

关键词

tetramethylpyrazinesepsiscardiac functionmortality rate

Keywords

tetramethylpyrazinesepsiscardiac functionmortality rate

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Library of Guangzhou University of Chinese Medicine

Hospital of Guangdong University of Technology

Department of Clinical Laboratory, the First Affiliated Hospital of Guangzhou University of Chinese Medicine

Department of Cerebropathia, the First Affiliated Hospital of Guangzhou University of Chinese Medicine

Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology

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