Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics

Xiao-yan Lu; Hao Xu; Geng Li; Tie Zhao

doi:10.1007/s11655-012-1182-z

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Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics

Updated：2021-08-27

- Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics
- Chinese Journal of Integrative Medicine Vol. 20, Issue 1, Pages: 68-71(2014)
- Affiliations：
  
  Department of Integrative Cardiology, China-Japan Friendship Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30901891)
- DOI：10.1007/s11655-012-1182-z
  CLC：
- Published：2014，
  
  Published Online：3 December 2012，
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Lu, Xy., Xu, H., Li, G. et al. Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics., Chin. J. Integr. Med. 20, 68–71 (2014). https://doi.org/10.1007/s11655-012-1182-z

Xiao-yan Lu, Hao Xu, Geng Li, et al. Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics. [J]. Chinese Journal of Integrative Medicine 20(1):68-71(2014)
Lu, Xy., Xu, H., Li, G. et al. Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics., Chin. J. Integr. Med. 20, 68–71 (2014). https://doi.org/10.1007/s11655-012-1182-z DOI：

Xiao-yan Lu, Hao Xu, Geng Li, et al. Study on correspondence between prescription and syndrome and the essence of phlegm and blood stasis syndrome in coronary heart disease based on metabonomics. [J]. Chinese Journal of Integrative Medicine 20(1):68-71(2014) DOI： 10.1007/s11655-012-1182-z.

摘要

Studying the essence of a syndrome has been a key challenge in the field of Chinese medicine. Until now

due to limitations of the methods available

the progress towards understanding such complicated systems has been slow. Metabonomics encompasses the dynamics

composition and analysis of metabolites

enabling the observation of changes in the metabolic network of the human body associated with disease. Being from the point of view of the whole organism

metabonomics provides an opportunity to study the essence of a syndrome to an unprecedented level. Phlegm and blood stasis syndrome is the main syndrome associated with coronary heart disease (CHD)

which bring difficulties in clinical treatment due to difficulties associated with differentiation of symptoms and signs. The fundamental differences of material between the two also need to be interpreted. The authors consider that we can use the method of combining a disease (in this case CHD) with associated syndromes (phlegm and blood stasis syndrome) to select patients with phlegm and blood stasis syndrome of CHD

and utilize metabonomics to explore the essence of the syndrome by difference analysis of metabolite spectra. Meanwhile

we can study the syndrome in CM

observe the change regularity of metabolism spectra after the treatment of corresponding and non-corresponding prescription and syndrome

in order to validate the material fundament in the progress of syndrome formation and their differences. This will not only have great significance in enhancing the ability to identify syndrome of phlegm and blood stasis in CHD and to establish the clinical curative criteria

but will also offer a new approach of studying the essence for a syndrome using metabonomics.

Abstract

Studying the essence of a syndrome has been a key challenge in the field of Chinese medicine. Until now

due to limitations of the methods available

the progress towards understanding such complicated systems has been slow. Metabonomics encompasses the dynamics

composition and analysis of metabolites

enabling the observation of changes in the metabolic network of the human body associated with disease. Being from the point of view of the whole organism

metabonomics provides an opportunity to study the essence of a syndrome to an unprecedented level. Phlegm and blood stasis syndrome is the main syndrome associated with coronary heart disease (CHD)

and utilize metabonomics to explore the essence of the syndrome by difference analysis of metabolite spectra. Meanwhile

we can study the syndrome in CM

observe the change regularity of metabolism spectra after the treatment of corresponding and non-corresponding prescription and syndrome

but will also offer a new approach of studying the essence for a syndrome using metabonomics.

关键词

metabonomicsphlegm and blood stasis syndromecoronary heart diseasecombination of disease with syndromecorrespondence between prescription and syndrome

Keywords

metabonomicsphlegm and blood stasis syndromecoronary heart diseasecombination of disease with syndromecorrespondence between prescription and syndrome

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Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Academy of Chinese Medical Sciences

Department of Cardiology, Guang’anmen Hospital

Guangdong Provincial Hospital of Chinese Medicine

Xiyuan Hospital, China Academy of Chinese Medical Sciences

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