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Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients
- Chinese Journal of Integrative Medicine Vol. 18, Issue 8, Pages: 635-640(2012)
- Affiliations：
Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari,Iran
- Author bio：
- Funds：
DOI：10.1007/s11655-012-1183-y
CLC：Published：2012，
Published Online：2 August 2012，
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Ahmadi, A. Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients., Chin. J. Integr. Med. 18, 635–640 (2012). https://doi.org/10.1007/s11655-012-1183-y
Amirhossein Ahmadi. Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. [J]. Chinese Journal of Integrative Medicine 18(8):635-640(2012)
Ahmadi, A. Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients., Chin. J. Integr. Med. 18, 635–640 (2012). https://doi.org/10.1007/s11655-012-1183-y DOI：
Amirhossein Ahmadi. Potential prevention: Aloe vera mouthwash may reduce radiation-induced oral mucositis in head and neck cancer patients. [J]. Chinese Journal of Integrative Medicine 18(8):635-640(2012) DOI： 10.1007/s11655-012-1183-y.
摘要
In recent years
more head and neck cancer patients have been treated with radiotherapy. Radiation-induced mucositis is a common and dose limiting toxicity of radiotherapy among patients with head and neck cancers. Patients undergoing radiation therapy for head and neck cancer are also at increased risk of developing oral candidiasis. A number of new agents applied locally or systemically to prevent or treat radiationinduced mucositis have been investigated
but there is no widely accepted prophylactic or effective treatment for mucositis. Topical Aloe vera is widely used for mild sunburn
frostbites
and scalding burns. Studies have reported the beneficial effects of Aloe gel for wound healing
mucous membrane protection
and treatment of oral ulcers
in addition to antiinflammatory
immunomudulation
antifungal
scavenging free radicals
increasing collagen formation and inhibiting collagenase. Herein the author postulates that oral Aloe vera mouthwash may not only prevent radiation-induced mucositis by its wound healing and antiinflammatory mechanism
but also may reduce oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties. Hence
Aloe vera mouthwash may provide an alternative agent for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
Abstract
In recent years
more head and neck cancer patients have been treated with radiotherapy. Radiation-induced mucositis is a common and dose limiting toxicity of radiotherapy among patients with head and neck cancers. Patients undergoing radiation therapy for head and neck cancer are also at increased risk of developing oral candidiasis. A number of new agents applied locally or systemically to prevent or treat radiationinduced mucositis have been investigated
but there is no widely accepted prophylactic or effective treatment for mucositis. Topical Aloe vera is widely used for mild sunburn
frostbites
and scalding burns. Studies have reported the beneficial effects of Aloe gel for wound healing
mucous membrane protection
and treatment of oral ulcers
in addition to antiinflammatory
immunomudulation
antifungal
scavenging free radicals
increasing collagen formation and inhibiting collagenase. Herein the author postulates that oral Aloe vera mouthwash may not only prevent radiation-induced mucositis by its wound healing and antiinflammatory mechanism
but also may reduce oral candidiasis of patients undergoing head and neck radiotherapy due to its antifungal and immunomodulatory properties. Hence
Aloe vera mouthwash may provide an alternative agent for treating radiation-induced oral mucositis and candidiasis in patients with head and neck cancers.
关键词
Aloe veramouthwashradiotherapymucositishead and neck cancercandidiasis
Keywords
Aloe veramouthwashradiotherapymucositishead and neck cancercandidiasis
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