The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

Yu Feng; Yue-yong Xiao; Shao-dan Li; Ming-xiong Lin; Yin Zhang; Hai-ming Wang; Min Li; Xiao Zhang; Ke Cao; Yu-fei Ye; Li Zhao

doi:10.1007/s11655-012-1203-y

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The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine

Updated：2021-08-27

- The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine
- Chinese Journal of Integrative Medicine Vol. 18, Issue 9, Pages: 663-669(2012)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Chinese People’s Liberation Army General Hospital,Beijing,China
  2. Department of Radiology, Chinese People’s Liberation Army General Hospital,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1203-y
  CLC：
- Published：2012，
  
  Published Online：31 August 2012，
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Feng, Y., Xiao, Yy., Li, Sd. et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine., Chin. J. Integr. Med. 18, 663–669 (2012). https://doi.org/10.1007/s11655-012-1203-y

Yu Feng, Yue-yong Xiao, Shao-dan Li, et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine. [J]. Chinese Journal of Integrative Medicine 18(9):663-669(2012)
Feng, Y., Xiao, Yy., Li, Sd. et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine., Chin. J. Integr. Med. 18, 663–669 (2012). https://doi.org/10.1007/s11655-012-1203-y DOI：

Yu Feng, Yue-yong Xiao, Shao-dan Li, et al. The treatment of non-small cell lung cancer by interstitial I-125 seeds implantation combined with chemotherapy and Chinese medicine. [J]. Chinese Journal of Integrative Medicine 18(9):663-669(2012) DOI： 10.1007/s11655-012-1203-y.

摘要

To investigate the effects of brachytherapy with computed tomography-guided percutaneous radioactive I-125 seeds interstitial implantation (ISI) synchronized chemotherapy and Chinese medicine (CM) for the treatment of advanced stage of non-small cell lung cancer (NSCLC). Ninety patients diagnosed with NSCLC by biopsy were randomly assigned to three groups: the synchronized therapy group (A)

the chemotherapy plus CM-treated group (B)

and the chemotherapy-treated group (C); a 2-month course of treatment was administered to them all. The effectiveness of treatment was evaluated based on tumor size

tumor markers (carcinoembryonic

squamous cell carcinoma-associated antigen

and cytokeratin 19 fragment)

clinical symptoms

and quality of life (QOL) in patients. The total effective rates of Groups A to C were 83.33%

46.67%

and 43.33%

respectively. The tumor markers were reduced obviously in Group A

showing signifificant difference compared with those in the other two groups. Additionally

QOL was elevated and cancer-related symptoms were alleviated more signifificant in Group A than those in Group C (all P<0.05). The synchronized therapy of I-125 implantation with chemotherapy and CM was a safe therapeutic method and can be regarded as a new mode for treatment of advanced-stage NSCLC.

Abstract

the chemotherapy plus CM-treated group (B)

and the chemotherapy-treated group (C); a 2-month course of treatment was administered to them all. The effectiveness of treatment was evaluated based on tumor size

tumor markers (carcinoembryonic

squamous cell carcinoma-associated antigen

and cytokeratin 19 fragment)

clinical symptoms

and quality of life (QOL) in patients. The total effective rates of Groups A to C were 83.33%

46.67%

and 43.33%

respectively. The tumor markers were reduced obviously in Group A

showing signifificant difference compared with those in the other two groups. Additionally

关键词

advanced non-small cell lung cancerradioactive particlebrachytherapychemotherapyChinese Medicine

Keywords

advanced non-small cell lung cancerradioactive particlebrachytherapychemotherapyChinese Medicine

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