Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats

Jie Xue; Ke-ping Zhang; Lu-jia Zhu; Mei-lin Xie; Hong-quan Zhang

doi:10.1007/s11655-012-1209-5

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Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats

Updated：2021-08-27

- Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats
- Chinese Journal of Integrative Medicine Vol. 19, Issue 2, Pages: 137-142(2013)
- Affiliations：
  
  1. Department of Pharmacology, College of Pharmaceutical Science, Soochow University,Jiangsu Province,Suzhou,China
  2. Experimental Center of Medical and Biological Teaching, Medical College of Soochow University,Jiangsu Province,Suzhou,China
  3. Institute of Pharmaceutical Research in Yangzhou University,Jiangsu Province,Yangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1209-5
  CLC：
- Published：2013，
  
  Published Online：21 September 2012，
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Xue, J., Zhang, Kp., Zhu, Lj. et al. Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats., Chin. J. Integr. Med. 19, 137–142 (2013). https://doi.org/10.1007/s11655-012-1209-5

Jie Xue, Ke-ping Zhang, Lu-jia Zhu, et al. Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats. [J]. Chinese Journal of Integrative Medicine 19(2):137-142(2013)
Xue, J., Zhang, Kp., Zhu, Lj. et al. Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats., Chin. J. Integr. Med. 19, 137–142 (2013). https://doi.org/10.1007/s11655-012-1209-5 DOI：

Jie Xue, Ke-ping Zhang, Lu-jia Zhu, et al. Inhibitory effects of Qushuanling Capsule (祛栓灵胶囊) on thrombus formation and platelet aggregation in rats. [J]. Chinese Journal of Integrative Medicine 19(2):137-142(2013) DOI： 10.1007/s11655-012-1209-5.

摘要

To investigate the effects of Qushuanling Capsule (祛栓灵胶囊 QSLC) on thrombus formation and platelet aggregation in rats. Arteriovenous bypass

venous thrombosis

and middle cerebral artery thrombosis models were used in rats to investigate the anti-thrombotic effects of QSLC

a compound of nine Chinese herbs. The platelet aggregation induced by adenosine diphosphate (ADP)

thrombin or arachidonic acid (AA)

as well as the contents of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) in rat plasma and aortic walls

were determined to investigate the possible mechanisms of the anti-thrombotic effects of QSLC. After oral administration with QSLC for 7 days

arteriovenous bypass thrombosis was obviously suppressed compared with the model group

venous thrombosis was also obviously suppressed

rat behaviors were obviously improved

and brain infarct size as well as water content were also reduced. The platelet aggregation induced by ADP or thrombin was inhibited by QSLC

but the drug had no effect on AA-induced platelet aggregation and content of TXB2 and 6-keto-PGF1α in plasma and the aortic wall. These results suggest that QSLC can be used in the prevention and treatment of thrombotic diseases

and that its mechanism of action may be related to inhibition of platelet aggregation.

Abstract

To investigate the effects of Qushuanling Capsule (祛栓灵胶囊 QSLC) on thrombus formation and platelet aggregation in rats. Arteriovenous bypass

venous thrombosis

and middle cerebral artery thrombosis models were used in rats to investigate the anti-thrombotic effects of QSLC

a compound of nine Chinese herbs. The platelet aggregation induced by adenosine diphosphate (ADP)

thrombin or arachidonic acid (AA)

as well as the contents of thromboxane B2 (TXB2) and 6-keto-prostaglandin F1α (6-keto-PGF1α) in rat plasma and aortic walls

were determined to investigate the possible mechanisms of the anti-thrombotic effects of QSLC. After oral administration with QSLC for 7 days

arteriovenous bypass thrombosis was obviously suppressed compared with the model group

venous thrombosis was also obviously suppressed

rat behaviors were obviously improved

and brain infarct size as well as water content were also reduced. The platelet aggregation induced by ADP or thrombin was inhibited by QSLC

and that its mechanism of action may be related to inhibition of platelet aggregation.

关键词

Qushuanling CapsulethrombosisPlatelet Aggregation

Keywords

Qushuanling CapsulethrombosisPlatelet Aggregation

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