Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity

Hong-zhan Li; Yong-heng Lu; Guang-sheng Huang; Qi Chen; Qiang Fu; Zhi-liang Li

doi:10.1007/s11655-012-1213-9

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Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity

Updated：2021-08-27

- Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity
- Chinese Journal of Integrative Medicine Vol. 20, Issue 10, Pages: 764-769(2014)
- Affiliations：
  
  1. Integrative Hospital, College of Chinese Medicine, Southern Medical University,Guangzhou,China
  2. Zhujiang Hospital, Southern Medical University,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by Administration of Traditional Chinese Medicine of Guangdong Province, China (No. 2010424)
- DOI：10.1007/s11655-012-1213-9
  CLC：
- Published：2014，
  
  Published Online：21 September 2012，
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Li, Hz., Lu, Yh., Huang, Gs. et al. Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity., Chin. J. Integr. Med. 20, 764–769 (2014). https://doi.org/10.1007/s11655-012-1213-9

Hong-zhan Li, Yong-heng Lu, Guang-sheng Huang, et al. Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity. [J]. Chinese Journal of Integrative Medicine 20(10):764-769(2014)
Li, Hz., Lu, Yh., Huang, Gs. et al. Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity., Chin. J. Integr. Med. 20, 764–769 (2014). https://doi.org/10.1007/s11655-012-1213-9 DOI：

Hong-zhan Li, Yong-heng Lu, Guang-sheng Huang, et al. Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity. [J]. Chinese Journal of Integrative Medicine 20(10):764-769(2014) DOI： 10.1007/s11655-012-1213-9.

摘要

Antigen-presenting cells such as monocytes and dendritic cells (DCs) stimulate T-cell proliferation and activation during adaptive immunity. This cellular interaction plays a role in the growth of atherosclerotic plaques. Tanshinone II A (TSN) had been shown to decrease the growth of atherosclerotic lesions. We therefore investigated the ability of TSN to inhibit human monocyte-derived DCs and their T-cellstimulatory capacity. DCs derived from human monocytes cultured with recombinant human interleukin (IL)-4 and recombinant human granulocyte-macrophage colony-stimulating factor were co-cultured with TSN and lipopolysaccharide for 48 h. Phosphate-buffered saline was used as a negative control. Activation markers and the capacity of DCs for endocytosis were measured by flow cytometry

and proinflammatory cytokines were measured by enzyme-linked immunosorbent assays. DCs were co-cultured with lymphocytes to measure T-cell proliferation and IL-2 secretion by mixed lymphocyte reactions. TSN dose-dependently attenuated DC expression of costimulatory molecules (CD86)

and decreased expression of major histocompatibility complex class II (human loukocyte antigen-DR) and adhesion molecules (CD54). Moreover

TSN reduced secretion of the proinflammatory cytokines IL-12 and IL-1 by human DCs

and restored the capacity for endocytosis. Finally

TSN-preincubated DCs showed a reduced capacity to stimulate T-cell proliferation and cytokine secretion. TSN inhibits DC maturation and decreases the expression of proinflammatory cytokines

while impairing their capacity to stimulate T-cell proliferation and cytokine secretion. These effects may contribute to the influence of TSN on the progression of atherosclerotic lesions.

Abstract

and decreased expression of major histocompatibility complex class II (human loukocyte antigen-DR) and adhesion molecules (CD54). Moreover

TSN reduced secretion of the proinflammatory cytokines IL-12 and IL-1 by human DCs

and restored the capacity for endocytosis. Finally

TSN-preincubated DCs showed a reduced capacity to stimulate T-cell proliferation and cytokine secretion. TSN inhibits DC maturation and decreases the expression of proinflammatory cytokines

while impairing their capacity to stimulate T-cell proliferation and cytokine secretion. These effects may contribute to the influence of TSN on the progression of atherosclerotic lesions.

关键词

dendritic cellsimmunityatherosclerosistanshinone II A

Keywords

dendritic cellsimmunityatherosclerosistanshinone II A

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Institute of Basic Theories of Traditional Chinese Medicine, China Academy of Traditional Chinese Medicine

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