Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial

Chien-Ying Lee; Min-Chien Yu; Chun-Che Lin; Ming-Yung Lee; James Cheng-Chung Wei; Hung-Che Shih

doi:10.1007/s11655-012-1219-3

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Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial

Updated：2021-08-27

- Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial
- Chinese Journal of Integrative Medicine Vol. 21, Issue 8, Pages: 587-593(2015)
- Affiliations：
  
  1. Institute of Medicine, Chung Shan Medical University, Taichung,Taiwan,China
  2. Department of Pharmacy, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  3. Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  4. Department of Integrated Chinese and Western Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  5. Division of Hepatogastroenterology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung,Taiwan,China
  6. Department of Statistics and Informatics Science, Providence University, Taichung,Taiwan,China
  7. Graduate Institute of Integrated Medicine, China Medical University, Taichung,Taiwan,China
  8. Department of Pharmacology, Chung Shan Medical University, Taichung,Taiwan,China
- Author bio：
- Funds：
  
  James Cheng-Chung Wei and Hung-Che Shih contributed equally to this study
- DOI：10.1007/s11655-012-1219-3
  CLC：
- Published：2015，
  
  Published Online：28 February 2013，
Scan for full text
Lee, CY., Yu, MC., Lin, CC. et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 587–593 (2015). https://doi.org/10.1007/s11655-012-1219-3

Chien-Ying Lee, Min-Chien Yu, Chun-Che Lin, et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 21(8):587-593(2015)
Lee, CY., Yu, MC., Lin, CC. et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 587–593 (2015). https://doi.org/10.1007/s11655-012-1219-3 DOI：

Chien-Ying Lee, Min-Chien Yu, Chun-Che Lin, et al. Efficacy and safety of herbal medicine yun-cai tea in the treatment of hyperlipidemia: A double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 21(8):587-593(2015) DOI： 10.1007/s11655-012-1219-3.

摘要

Animal studies have demonstrated a lipid-modulating effect of yun-cai tea. However

little is known about the lipid-lowering effect in humans.The aim of this study was to evaluate the lipid lowering effects and safety of yun-cai tea in patients with elevated lipid levels in a human clinical trial. This was a 12-week

randomly assigned

parallel-group

double-blind

and placebo-controlled pilot clinical study. Sixty primary hyperlipidemia patients were included and randomly assigned to the yun-cai tea group (30 patients) and the placebo group (30 patients)

for 8 weeks of treatment and 4 weeks of follow-up. The primary endpoint was changes in plasma low-density lipoprotein-cholesterol (LDL-C) at 8 weeks. The secondary endpoints included total cholesterol (TC) and triglycerides (TG). Our results revealed no statistically signifificant differences in LDL-C and TC between the two groups. Despite the lack of a statistically signifificant difference in the level of TG between the two groups

a declining trend was noted. A signifificant reduction of TG was observed in the yun-cai tea group at week 8

compared to baseline (P=0.048). The incidence of stomach discomfort

gastroesophageal reflfl ux

diarrhea

and constipation was slightly higher in the yun-cai tea group. No other signifificant adverse events were found. It is unlikely that yun-cai tea used had a blood lipid reduction effect. Further larger scale clinical trials with a longer duration and larger dose are necessary.

Abstract

Animal studies have demonstrated a lipid-modulating effect of yun-cai tea. However

randomly assigned

parallel-group

double-blind

and placebo-controlled pilot clinical study. Sixty primary hyperlipidemia patients were included and randomly assigned to the yun-cai tea group (30 patients) and the placebo group (30 patients)

a declining trend was noted. A signifificant reduction of TG was observed in the yun-cai tea group at week 8

compared to baseline (P=0.048). The incidence of stomach discomfort

gastroesophageal reflfl ux

diarrhea

关键词

yun-cai tealow-density lipoprotein-cholesterolTotal Cholesteroltriglycerides

Keywords

yun-cai tealow-density lipoprotein-cholesterolTotal Cholesteroltriglycerides

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