Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension

Song-lin Chen; Xiao-yun Liu; Wen-ming Xu; Wei-yi Mei; Xiao-lian Chen

doi:10.1007/s11655-012-1231-7

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Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension

Updated：2021-08-27

- Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension
- Chinese Journal of Integrative Medicine Vol. 18, Issue 10, Pages: 746-751(2012)
- Affiliations：
  
  1. Department of Neurology, First Affiliated Hospital of Sun Yatsen University,Guangzhou,China
  2. Department of Traditional Chinese Medicine, First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China
  3. Department of Endocrinology, First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China
  4. Department of Cardiology, First Affiliated Hospital of Sun Yat-sen University,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Guangdong Province, China (No. 0606300815;These authors contributed equally to this work
- DOI：10.1007/s11655-012-1231-7
  CLC：
- Published：2012，
  
  Published Online：11 September 2012，
Scan for full text
Chen, Sl., Liu, Xy., Xu, Wm. et al. Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension., Chin. J. Integr. Med. 18, 746–751 (2012). https://doi.org/10.1007/s11655-012-1231-7

Song-lin Chen, Xiao-yun Liu, Wen-ming Xu, et al. Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension. [J]. Chinese Journal of Integrative Medicine 18(10):746-751(2012)
Chen, Sl., Liu, Xy., Xu, Wm. et al. Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension., Chin. J. Integr. Med. 18, 746–751 (2012). https://doi.org/10.1007/s11655-012-1231-7 DOI：

Song-lin Chen, Xiao-yun Liu, Wen-ming Xu, et al. Clinical study of western medicine combined with Chinese medicine based on syndrome differentiation in the patients with polarized hypertension. [J]. Chinese Journal of Integrative Medicine 18(10):746-751(2012) DOI： 10.1007/s11655-012-1231-7.

摘要

To investigate the effects and safety of Western medicine combined with Chinese medicine (CM) based on syndrome differentiation in the treatment of elderly polarized hypertension (PHPT)

or isolated systolic hypertension with low diastolic blood pressure (DBP). A total of 125 elderly patients with PHPT were randomly assigned to two groups: 59 in the control group treated by Western medicine and 66 in the intervention group treated by Western medicine combined with CM treatment. Based on syndrome differentiation

the patients in the intervention group were further divided into subgroups of yang-qi deficiency and yin-qi deficiency. All subjects were treated with Western medicine of Amlodipine Besylate Tablets and Irbesartan Tablets (or Irbesartan and Hydrochlorothiazide Tablets)

to decrease their systolic blood pressure (SBP) slowly to 125–135 mm Hg in 2–6 weeks. In the intervention group

Shiyiwei Shenqi Capsule (十一味参芪胶囊) was given additionally to the subgroup of yang-qi deficiency at the dosage of 3-5 capsules

thrice a day

while Dengzhan Shengmai Capsule (灯盏生脉胶囊) was given additionally to the subgroup of yin-qi deficiency at the dosage of 2 capsules

2-3 times per day. For all subjects

SBP

pulse pressure (PP)

and DBP were measured before treatment and at the terminal of a 6-week treatment. For subjects in the intervention group

left ventricular ejection fraction (LVEF) was also recorded. After a 6-week treatment

the SBP in the two groups and the PP in the intervention group decreased significantly compared to those before treatment (P<0.05)

while the PP in the control group showed no significant difference between prior and post-treatment (P>0.05). After treatment

the DBP in the control group decreased (P>0.05)

while the DBP and LVEF in the intervention group showed an increase tendency although it had no statistical significance (P>0.05). When subjects in the intervention group were classified further by the course of disease

the DBP and LVEF of subjects whose course of disease were less than 2 years

increased significantly after treatment (P<0.05). Western medicine combined with CM treatment based on syndrome differentiation was safer and more effective than Western medicine alone in the treatment of elderly PHPT

because it not only reduced SBP but also improved DBP

which might lower the incidence of the cardiovascular and cerebrovascular events.

Abstract

To investigate the effects and safety of Western medicine combined with Chinese medicine (CM) based on syndrome differentiation in the treatment of elderly polarized hypertension (PHPT)

to decrease their systolic blood pressure (SBP) slowly to 125–135 mm Hg in 2–6 weeks. In the intervention group

Shiyiwei Shenqi Capsule (十一味参芪胶囊) was given additionally to the subgroup of yang-qi deficiency at the dosage of 3-5 capsules

thrice a day

while Dengzhan Shengmai Capsule (灯盏生脉胶囊) was given additionally to the subgroup of yin-qi deficiency at the dosage of 2 capsules

2-3 times per day. For all subjects

SBP

pulse pressure (PP)

and DBP were measured before treatment and at the terminal of a 6-week treatment. For subjects in the intervention group

left ventricular ejection fraction (LVEF) was also recorded. After a 6-week treatment

the SBP in the two groups and the PP in the intervention group decreased significantly compared to those before treatment (P<0.05)

while the PP in the control group showed no significant difference between prior and post-treatment (P>0.05). After treatment

the DBP in the control group decreased (P>0.05)

the DBP and LVEF of subjects whose course of disease were less than 2 years

because it not only reduced SBP but also improved DBP

which might lower the incidence of the cardiovascular and cerebrovascular events.

关键词

polarized hypertensionlow diastolic pressureChinese Medicinesyndrome differentiation and treatmentisolated hypertension with low diastolic blood pressure

Keywords

polarized hypertensionlow diastolic pressureChinese Medicinesyndrome differentiation and treatmentisolated hypertension with low diastolic blood pressure

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Department of Medical Statistics, School of Public Health, Sun Yat-sen University

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The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics’ Ministry of Public Health

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