Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice

Nan Yao; Rong-rong He; Xiao-hui Zeng; Xue-jun Huang; Tie-liang Du; Jing-chao Cui; Kurihara Hiroshi

doi:10.1007/s11655-012-1243-3

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Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice

Updated：2021-08-27

- Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice
- Chinese Journal of Integrative Medicine Vol. 20, Issue 1, Pages: 31-35(2014)
- Affiliations：
  
  1. Guangdong Provincial Institute of Traditional Chinese Medicine,Guangzhou,China
  2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1243-3
  CLC：
- Published：2014，
  
  Published Online：23 September 2012，
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Yao, N., He, Rr., Zeng, Xh. et al. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice., Chin. J. Integr. Med. 20, 31–35 (2014). https://doi.org/10.1007/s11655-012-1243-3

Nan Yao, Rong-rong He, Xiao-hui Zeng, et al. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice. [J]. Chinese Journal of Integrative Medicine 20(1):31-35(2014)
Yao, N., He, Rr., Zeng, Xh. et al. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice., Chin. J. Integr. Med. 20, 31–35 (2014). https://doi.org/10.1007/s11655-012-1243-3 DOI：

Nan Yao, Rong-rong He, Xiao-hui Zeng, et al. Hypotriglyceridemic effects of apple polyphenols extract via up-regulation of lipoprotein lipase in triton WR-1339-induced mice. [J]. Chinese Journal of Integrative Medicine 20(1):31-35(2014) DOI： 10.1007/s11655-012-1243-3.

摘要

To investigate the anti-hyperlipidemic effects of apple polyphenols extract (APE) in Triton WR-1339-induced endogenous hyperlipidemic model. Firstly

APE was isolated and purified from the pomace of Red Fuji Apple and contents of individual polyphenols in APE were determined using high-performance liquid chromatography-mass spectrometry (HPLC-MS). Secondly

forty male National Institude of Health (NIH) mice were randomly divided into 5 groups with 8 animals in each group. The Fenofibrate Capsules (FC) group and APE groups received oral administration of respective drugs for 7 consecutive days. All mice except those in the normal group were intravenously injected through tail vein with Triton WR-1339 on the 6th day. Serum and livers from all the mice were obtained 18 h after the injection. The changes in serum total cholesterol (TC)

triglyceride (TG)

lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) were measured by respective kits. Finally

expression of hepatic peroxisome proliferator-activated receptor alpha (PPARα) mRNA was measured by real-time reverse transcription-polymerase chain reaction (RT-PCR) method. APE could reduce TG level via up-regulation of LPL activity

which provides new evidence to elucidate the anti-hyperlipidemic effects of APE.

Abstract

To investigate the anti-hyperlipidemic effects of apple polyphenols extract (APE) in Triton WR-1339-induced endogenous hyperlipidemic model. Firstly

triglyceride (TG)

lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) were measured by respective kits. Finally

which provides new evidence to elucidate the anti-hyperlipidemic effects of APE.

关键词

apple polyphenols extractTriton WR-1339triglycerideLipoprotein Lipaseperoxisome proliferator-activated receptor alpha

Keywords

apple polyphenols extractTriton WR-1339triglycerideLipoprotein Lipaseperoxisome proliferator-activated receptor alpha

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