A new strategy in drug design of chinese medicine: Theory, method and techniques

Hong-jun Yang; Dan Shen; Hai-yu Xu; Peng Lu

doi:10.1007/s11655-012-1270-x

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A new strategy in drug design of chinese medicine: Theory, method and techniques

Updated：2021-08-27

- A new strategy in drug design of chinese medicine: Theory, method and techniques
- Chinese Journal of Integrative Medicine Vol. 18, Issue 11, Pages: 803-806(2012)
- Affiliations：
  
  1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing,China
  2. Institute of Automation, Chinese Academy of Sciences,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-012-1270-x
  CLC：
- Published：2012，
  
  Published Online：20 October 2012，
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Yang, Hj., Shen, D., Xu, Hy. et al. A new strategy in drug design of chinese medicine: Theory, method and techniques., Chin. J. Integr. Med. 18, 803–806 (2012). https://doi.org/10.1007/s11655-012-1270-x

Hong-jun Yang, Dan Shen, Hai-yu Xu, et al. A new strategy in drug design of chinese medicine: Theory, method and techniques. [J]. Chinese Journal of Integrative Medicine 18(11):803-806(2012)
Yang, Hj., Shen, D., Xu, Hy. et al. A new strategy in drug design of chinese medicine: Theory, method and techniques., Chin. J. Integr. Med. 18, 803–806 (2012). https://doi.org/10.1007/s11655-012-1270-x DOI：

Hong-jun Yang, Dan Shen, Hai-yu Xu, et al. A new strategy in drug design of chinese medicine: Theory, method and techniques. [J]. Chinese Journal of Integrative Medicine 18(11):803-806(2012) DOI： 10.1007/s11655-012-1270-x.

摘要

The research and development (R&D) process of Chinese medicine

with one notable feature

clinical application based

is significantly different from which of chemical and biological medicine

from laboratory research to clinics. Besides

compound prescription is another character. Therefore

according to different R&D theories between Chinese and Western medicine

we put forward a new strategy in drug design of Chinese medicine

which focuses on “combination-activity relationship (CAR)”

taking prescription discovery

component identification and formula optimization as three key points to identify the drugs of high efficacy and low toxicity. The method of drug design of Chinese medicine includes: new prescription discovery based on clinical data and literature information

component identification based on computing and experimental research

as well as formula optimization based on system modeling. This paper puts forward the concept

research framework and techniques of drug design of Chinese medicine

which embodies the R&D model of Chinese medicine

hoping to support the drug design of Chinese medicine theoretically and technologically.

Abstract

The research and development (R&D) process of Chinese medicine

with one notable feature

clinical application based

is significantly different from which of chemical and biological medicine

from laboratory research to clinics. Besides

compound prescription is another character. Therefore

according to different R&D theories between Chinese and Western medicine

we put forward a new strategy in drug design of Chinese medicine

which focuses on “combination-activity relationship (CAR)”

taking prescription discovery

component identification based on computing and experimental research

as well as formula optimization based on system modeling. This paper puts forward the concept

research framework and techniques of drug design of Chinese medicine

which embodies the R&D model of Chinese medicine

hoping to support the drug design of Chinese medicine theoretically and technologically.

关键词

drug design of Chinese medicinecombination-activity relationshipprescription discoverycomponent identificationformula optimizationsystem modeling

Keywords

drug design of Chinese medicinecombination-activity relationshipprescription discoverycomponent identificationformula optimizationsystem modeling

references

Wu JA, Ji RY. Application of QSAR in drug design. Foreign Med Sci·Pharm Sect (Chin) 1989;16(1):8–16.

Xu HY, Tang SH, Chen JX, Li DF, Chen C, Yang HJ, et al. Thinking and strategy on combination-activity relationship (CAR) of Chinese medicine based on metabonomics. World Sci Technol-Modern Chin Med (Chin) 2011;13(1):30–35.

Yang HJ, Chen JX, Tang SH, Li ZK, Zhen YS, Huang LQ, et al. New drug R&D of traditional Chinese medicine—role of data mining approaches. J Biol System 2009;17:329–347.

Tang SH, Chen JX, Li G, Wu HW, Chen C, Zhang N, et al. Research on component law of Chinese patent medicine for anti-influenza and development of new recipes for antiinfluenza by unsupervised data mining methods. J Tradit Chin Med 2010;30:288–293.

Lu P, Li J, Tang SH, Chen JX, Zuo XH, Liu X, et al. Development and application of traditional Chinese medicine inheritance support system. Chin J Experim Tradit Med Formul (Chin) 2009;18(9):1–4.

Chen C, Chen JX, Wu HW, Tang SH, Li G, Yi JQ, et al. Identification of key constituents in volatile oil of Ligusticum Chuanxiong based on data mining approaches. Pharmaceut Biol 2011;49:445–455.

Xu HY, Huang LQ, Lu P, Yang HJ. Modernization research thoughts of Chinese medicine based on in vivo ADME process and network pharmacology. China J Chin Mater Med (Chin) 2012;37:142–145.

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