Chemistry and pharmacology of 4-hydroxylonchocarpin: A review

Victor Kuete; Jaures A. K. Noumedem; Frederic Nana

doi:10.1007/s11655-013-1195-7

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Chemistry and pharmacology of 4-hydroxylonchocarpin: A review

Updated：2021-08-27

- Chemistry and pharmacology of 4-hydroxylonchocarpin: A review
- Chinese Journal of Integrative Medicine Vol. 19, Issue 6, Pages: 475-480(2013)
- Affiliations：
  
  1. Department of Biochemistry, Faculty of Science, University of Dschang, Yaounde,Cameroon
  2. Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde,Cameroon
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1195-7
  CLC：
- Published：2013，
  
  Published Online：20 June 2013，
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Kuete, V., Noumedem, J.A.K. & Nana, F. Chemistry and pharmacology of 4-hydroxylonchocarpin: A review., Chin. J. Integr. Med. 19, 475–480 (2013). https://doi.org/10.1007/s11655-013-1195-7

Victor Kuete, Jaures A. K. Noumedem, Frederic Nana. Chemistry and pharmacology of 4-hydroxylonchocarpin: A review. [J]. Chinese Journal of Integrative Medicine 19(6):475-480(2013)
Kuete, V., Noumedem, J.A.K. & Nana, F. Chemistry and pharmacology of 4-hydroxylonchocarpin: A review., Chin. J. Integr. Med. 19, 475–480 (2013). https://doi.org/10.1007/s11655-013-1195-7 DOI：

Victor Kuete, Jaures A. K. Noumedem, Frederic Nana. Chemistry and pharmacology of 4-hydroxylonchocarpin: A review. [J]. Chinese Journal of Integrative Medicine 19(6):475-480(2013) DOI： 10.1007/s11655-013-1195-7.

摘要

4-hydroxylonchocarpin (LCP) or 2′

4-dihydroxy-3′

4′-(2

2-dimethylchromene) chalcone is a chalcone of the class flavonoid

with a molecular weight of 322 g/mol mostly isolated in the family Moraceae and Leguminosae. LCP was reported to have a variety of pharmacological activities such as antibacterial

antifungal

anticancer

anti-reverse transcriptase

antitubercular

antimalarial

anti-inflammatory

ornitnine decarboxylase activity and antioxidant. The hemisynthesis of the compound has been described. The present review was undertaken to bring out together the knowledge on LCP

and can serve as the start point for future research and valorization accomplishments.

Abstract

4-hydroxylonchocarpin (LCP) or 2′

4-dihydroxy-3′

4′-(2

2-dimethylchromene) chalcone is a chalcone of the class flavonoid

with a molecular weight of 322 g/mol mostly isolated in the family Moraceae and Leguminosae. LCP was reported to have a variety of pharmacological activities such as antibacterial

antifungal

anticancer

anti-reverse transcriptase

antitubercular

antimalarial

anti-inflammatory

ornitnine decarboxylase activity and antioxidant. The hemisynthesis of the compound has been described. The present review was undertaken to bring out together the knowledge on LCP

and can serve as the start point for future research and valorization accomplishments.

关键词

4-hydroxylonchocarpinbiosynthesissynthesispharmacology

Keywords

4-hydroxylonchocarpinbiosynthesissynthesispharmacology

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