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A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia
- Chinese Journal of Integrative Medicine Vol. 19, Issue 1, Pages: 22-28(2013)
- Affiliations：
1. Chinese PLA Postgraduate Medical School,Beijing,China
2. Department of Chinese Medicine, the First Hospital Affiliated to Chinese PLA General Hospital,Beijing,China
3. Japan Friendship Hospital,, China,Beijing,China
4. Chinese PLA Troop,Beijing,China,61660
- Author bio：
- Funds：The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag Berlin Heidelberg 2013 Supported by the Development Fund of the First Hospital Affilicated to Chinese PLA General Hospital Research (No. ZZ2004020)
DOI：10.1007/s11655-013-1321-6
CLC：Published：2013，
Published Online：29 December 2012，
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Li, Sn., Qian, Lq., Ma, Jl. et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia., Chin. J. Integr. Med. 19, 22–28 (2013). https://doi.org/10.1007/s11655-013-1321-6
Su-na Li, Li-qi Qian, Jian-li Ma, et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia. [J]. Chinese Journal of Integrative Medicine 19(1):22-28(2013)
Li, Sn., Qian, Lq., Ma, Jl. et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia., Chin. J. Integr. Med. 19, 22–28 (2013). https://doi.org/10.1007/s11655-013-1321-6 DOI：
Su-na Li, Li-qi Qian, Jian-li Ma, et al. A randomized trial of chinese medicine lirukang granule (利乳康颗粒) combined with psychological intervention for cyclomastopathy and menoxenia. [J]. Chinese Journal of Integrative Medicine 19(1):22-28(2013) DOI： 10.1007/s11655-013-1321-6.
摘要
To observe the influence of therapy with Chinese medicine Lirukang Granule (利乳康颗粒
LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia. A total of 470 subjects were randomly assigned to three groups by the net-central randomization system
the treatment group (161 patients
treated with LRKG and psychological intervention)
the Chinese medicine group (157 patients
treated with LRKG)
and the psychological intervention group (152 patients
treated with psychological intervention). The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations
cognitive intervention and psychological persuasion
30–40 min per session
once a week. The therapy duration for all groups was three months. The efficacy was compared and anxiety state/State-Trait Anxiety Invertory (STAI) scoring was measured before and after treatment. The serum estradiol (E2)
progesterone (P)
prolactin (PRL) and follicle stimulating hormone (FSH) levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment
and a group of 20 healthy women were evaluated for comparison. A follow-up was arranged for one year after treatment. Thirty subjects were lost to follow-up. (1) Comparison of efficacy: the markedly effective rate and the total effective rate of the treatment group were 86.67% (131/150) and 98.00% (147/150)
respectively; of the Chinese medicine group
64.58% (93/144) and 90.27% (130/144)
respectively; and of the psychological intervention group
0% (0/146) and 3.42% (5/146)
respectively. The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups (P<0.05). (2) Comparison of STAI scoring: STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group (P<0.01)
but there was no significant difference compared with the psychological intervention group. (3) Comparison of levels of sex hormones: E2
P
PRL and FSH of the three patient groups were disordered before treatment
and significantly different from healthy women (P<0.01). After treatment
the levels of P and FSH of the treatment group were significantly increased (P<0.01)
E and PRL were significantly reduced
which were also significantly decreased compared with the psychological intervention groups (P<0.01). (4) Follow-up: the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment (P<0.05). (5) Adverse reactions: no obvious adverse reactions were found among the three groups. Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia. The mechanism might be related to the regulation of sex hormones.
Abstract
To observe the influence of therapy with Chinese medicine Lirukang Granule (利乳康颗粒
LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia. A total of 470 subjects were randomly assigned to three groups by the net-central randomization system
the treatment group (161 patients
treated with LRKG and psychological intervention)
the Chinese medicine group (157 patients
treated with LRKG)
and the psychological intervention group (152 patients
treated with psychological intervention). The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations
cognitive intervention and psychological persuasion
30–40 min per session
once a week. The therapy duration for all groups was three months. The efficacy was compared and anxiety state/State-Trait Anxiety Invertory (STAI) scoring was measured before and after treatment. The serum estradiol (E2)
progesterone (P)
prolactin (PRL) and follicle stimulating hormone (FSH) levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment
and a group of 20 healthy women were evaluated for comparison. A follow-up was arranged for one year after treatment. Thirty subjects were lost to follow-up. (1) Comparison of efficacy: the markedly effective rate and the total effective rate of the treatment group were 86.67% (131/150) and 98.00% (147/150)
respectively; of the Chinese medicine group
64.58% (93/144) and 90.27% (130/144)
respectively; and of the psychological intervention group
0% (0/146) and 3.42% (5/146)
respectively. The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups (P<0.05). (2) Comparison of STAI scoring: STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group (P<0.01)
but there was no significant difference compared with the psychological intervention group. (3) Comparison of levels of sex hormones: E2
P
PRL and FSH of the three patient groups were disordered before treatment
and significantly different from healthy women (P<0.01). After treatment
the levels of P and FSH of the treatment group were significantly increased (P<0.01)
E and PRL were significantly reduced
which were also significantly decreased compared with the psychological intervention groups (P<0.01). (4) Follow-up: the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment (P<0.05). (5) Adverse reactions: no obvious adverse reactions were found among the three groups. Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia. The mechanism might be related to the regulation of sex hormones.
关键词
Lirukang Granulepsychological interventioncyclomastopathymenoxeniasex hormone
Keywords
Lirukang Granulepsychological interventioncyclomastopathymenoxeniasex hormone
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