Observation on effects of aconitine via acupoint injection in rabbits

Feng Ni; Jing-yu Lin; Dan Guo; Chun-quan Zhou; Xin Yao; Hong-zhi Ye; Guang-wen Wu

doi:10.1007/s11655-013-1324-3

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Observation on effects of aconitine via acupoint injection in rabbits

Updated：2021-08-27

- Observation on effects of aconitine via acupoint injection in rabbits
- Chinese Journal of Integrative Medicine Vol. 19, Issue 1, Pages: 36-41(2013)
- Affiliations：
  
  1. Department of Pharmacy, Fujian Health College,Fuzhou,China
  2. Fujian Institute of Traditional Chinese Medicine,Fuzhou,China
  3. Fujian Academy of Integrative Medicine,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30973719), the Project of the Fujian Ministry of Education (No. JA09134) and CHEN Ke-ji Development Foundation of Integrated Traditional Chinese Medicine and Western Medicine (No. CKJ2008003)
- DOI：10.1007/s11655-013-1324-3
  CLC：
- Published：2013，
  
  Published Online：29 December 2012，
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Ni, F., Lin, Jy., Guo, D. et al. Observation on effects of aconitine via acupoint injection in rabbits., Chin. J. Integr. Med. 19, 36–41 (2013). https://doi.org/10.1007/s11655-013-1324-3

Feng Ni, Jing-yu Lin, Dan Guo, et al. Observation on effects of aconitine via acupoint injection in rabbits. [J]. Chinese Journal of Integrative Medicine 19(1):36-41(2013)
Ni, F., Lin, Jy., Guo, D. et al. Observation on effects of aconitine via acupoint injection in rabbits., Chin. J. Integr. Med. 19, 36–41 (2013). https://doi.org/10.1007/s11655-013-1324-3 DOI：

Feng Ni, Jing-yu Lin, Dan Guo, et al. Observation on effects of aconitine via acupoint injection in rabbits. [J]. Chinese Journal of Integrative Medicine 19(1):36-41(2013) DOI： 10.1007/s11655-013-1324-3.

摘要

To investigate the ability of the pericardium meridian (PM) to mitigate or enhance the cardiotoxic effects of aconitine injected at specific acupoint and non-acupoint sites in rabbits. This study consisted of 3 experiments that were designed to test the effects of injection of 30 μg/kg of aconitine at acupoints on the PM (Test 1)

at non-acupoint sites on the PM (Test 2)

and at acupoints on other meridians and non-meridian sites (Test 3). In Test 1

24 rabbits were randomly assigned to receive injections at Quze (PC3)

Tianquan (PC2)

or intramuscularly. In Test 2

24 rabbits were randomly assigned to receive injections of aconitine at non-acupoint I

non-acupoint II

or intramuscularly. In Test 3

48 rabbits were randomly assigned to receive injections at Neiguan (PC6)

Sanyinjiao (SP6)

Yangjiao (GB35)

a non-meridian and non-acupoint site (NMNA)

intravenously

and intramuscularly. Electrocardiographs of the rabbits were performed before

during and after injection to determine the incidence of arrhythmia

latency of ventricular rhythm

and recovery rate after aconitine injection. The recovery time index and extent of arrhythmia scores were calculated. In all groups the incidence of arrhythmia was 100%

and the latency of ventricular rhythm was less than 30 min. In Tests 1 and 2

the recovery rates of the Quze and non-acupoint II groups were significantly higher than those of the muscular group (P<0.05). In Test 3

the recovery time index and extent of arrhythmia scores of the Neiguan group were low. There were no significant differences between the other acupoint groups

or the NMNA group

when compared with the group receiving aconitine intramuscularly. Acupoints or non-acupoints along the PM could reduce the severity of the arrhythmia induced by aconitine in healthy rabbits. Meridians play an important role in protecting body functions

Abstract

at non-acupoint sites on the PM (Test 2)

and at acupoints on other meridians and non-meridian sites (Test 3). In Test 1

24 rabbits were randomly assigned to receive injections at Quze (PC3)

Tianquan (PC2)

or intramuscularly. In Test 2

24 rabbits were randomly assigned to receive injections of aconitine at non-acupoint I

non-acupoint II

or intramuscularly. In Test 3

48 rabbits were randomly assigned to receive injections at Neiguan (PC6)

Sanyinjiao (SP6)

Yangjiao (GB35)

a non-meridian and non-acupoint site (NMNA)

intravenously

and intramuscularly. Electrocardiographs of the rabbits were performed before

during and after injection to determine the incidence of arrhythmia

latency of ventricular rhythm

and recovery rate after aconitine injection. The recovery time index and extent of arrhythmia scores were calculated. In all groups the incidence of arrhythmia was 100%

and the latency of ventricular rhythm was less than 30 min. In Tests 1 and 2

the recovery rates of the Quze and non-acupoint II groups were significantly higher than those of the muscular group (P<0.05). In Test 3

the recovery time index and extent of arrhythmia scores of the Neiguan group were low. There were no significant differences between the other acupoint groups

or the NMNA group

关键词

AconitineacupointmeridianacupuncturearrhythmiaChinese Medicine

Keywords

AconitineacupointmeridianacupuncturearrhythmiaChinese Medicine

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